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The bacterium that causes syphilis is called treponema pallidum. This spiral-shaped pathogen causes infections when it comes into an open wound or mucus membranes in genitals.

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After six weeks of being in the body, a chancre is produced which can transmit the disease. The second stage is when rashes all over the body appear, fever and joint pain occur, and hair loss is possible. Symptoms can go on for years and can progress into Tertiary Syphilis. This will produce destructive lesions in the brain, and damages to cardiovascular organs, bones, and joints.

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While some newborns may not show symptoms at first, early symptoms include jaundice, swelling of joints, skin rash, anemia, enlarged liver or spleen, and nasal discharge. Late symptoms can include bone abnormalities, notched teeth, vision problems, hearing loss, and neurological issues.

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Untreated syphilis can lead to a multitude of health issues, including death. Some of these are long-term complications affecting the brain, heart, eyes, and nervous system. This includes dementia, paralysis, seizures, blindness, aneurysm, deafness, or skin and bone gummas.

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Antibiotics can treat the infection, but not repair the damage. A singe injection of penicillin can cure syphilis.