# data[].attributes.headline
Table shows BLASTp hits of protein sequence – excluding mammals.

# data[].attributes.subject
Table shows BLASTp hits of protein sequence – excluding mammals.

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| Animal | Identity | Query cover | Accession no:
| Pelodiscus sinensis, Chinese softshell turtle | 95% | 76.71% | XP_006128401.1
| Terrapene mexicana triunguis, Mexican box turtle | 95% | 76.32% | XP_024048785.1
| Chrysemys picta bellii, Painted turtle | 95% | 76.32% | XP_008167416.1

# data[].attributes.headline
Table shows BLASTp hits of protein sequences - excluding primates.

# data[].attributes.subject
Table shows BLASTp hits of protein sequences - excluding primates.

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| Animal | Identity | Query cover | Accession no:
| Galeopterus variegatus, Sunda flying lemur | 100% | 93.99% | XP_008577089.1
| Elephantulus edwardii, Cape elephant shrew | 100% | 92.79% | XP_006892526.1
| Pteropus vampyrus, Large flying fox | 100% | 92.77% | XP_011362433.1

# data[].attributes.headline
Table shows BLASTp hits of protein sequences

# data[].attributes.subject
Table shows BLASTp hits of protein sequences

# data[].attributes.body
| Animal | Identity | Query cover | Accession no:
| Pan troglodytes, Chimpanzee | 100% | 99.70% | XP_001164380.2
| Pongo abelii, Sumatran orangutan | 100% | 99.10% | XP_002820344.1
| Nomascus leucogenys, Northern white-cheeked gibbon | 100% | 98.80% | XP_003264290.1

# data[].attributes.headline
Table shows the top 3 BLAST hits of nucleotide sequence excluding mammals.

# data[].attributes.subject
Table shows the top 3 BLAST hits of nucleotide sequence excluding mammals.

# data[].attributes.body
| Animal | Identity | Query cover | Accession no:
| Ornithorhynchus anatinus, Platypus | 48% | 80.37% | XM_001508576.3
| Pelodiscus sinensis, Chinese softshell turtle | 46% | 78.09% | XM_006128339.3
| Crocodylus porosus, Saltwater crocodile | 46% | 74.95% | XM_019540775.1

# data[].attributes.headline
Table shows the top 3 BLAST hits of nucleotide sequence excluding primates

# data[].attributes.subject
Table shows the top 3 BLAST hits of nucleotide sequence excluding primates

# data[].attributes.body
| Animal | Identity | Query cover | Accession no:
| Neomonachus schauinslandi, Hawaiian monk seal | 68% | 86.50% | XM_021691703.1
| Eumetopias jubatus, Steller sea lion | 68% | 86.48% | XM_028090559.1
| Loxodonta Africana, African bush elephant | 72% | 85.49% | XM_003407606.3

# data[].attributes.headline
Table shows the first 3 BLAST hits of animal nucleotide sequences – excluded Homo sapiens.

# data[].attributes.subject
Table shows the first 3 BLAST hits of animal nucleotide sequences – excluded Homo sapiens.

# data[].attributes.body
| Animal | Identity | Query cover | Accession no:
| Gorilla | 99% | 98.94% | XM_004048724.2
| Pan troglodytes, Chimpanzees | 99% | 98.80% | XM_001164380.4
| Pongo abelii, Sumatran orangutan | 99% | 98.27% | XM_002820298.4

# data[].attributes.headline
Prediction sequence for peptide and the coding sequence TOR1A gene.

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Prediction sequence for peptide and the coding sequence TOR1A gene.

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Disease:

Diseases which are caused by mutation of TOR1A are Dystonia 1, Torsion, Autosomal Dominant and Dyt-Tor1a. Dystonia 1 is a neurological condition causing involuntary muscle movements, such as contractions and painful spasms. It is a very rare condition which can affect the whole body, even lead to disability.  First symptoms started in childhood and get worse with patient age. Neuroradiologic studies on DYT1 mutation carriers exhibit mild abnormalities in motor behaviour. Brain functioning shows an innate compensation for mild striatal dysfunction.

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Gene TOR1A is expressed in 27 different tissues but it is mostly expressed in the thyroid glands and the urinary bladder. 

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Gene TOR1A is expressed in 27 different tissues but it is mostly expressed in the thyroid glands and the urinary bladder. 

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Gene:TOR1A

Full gene name:torsin family 1 member A

Also known as:  DQ2 or DYT1

Species:Homo sapiens

Genomic Locations for TOR1A Gene:

·         chr9:129,812,942-129,824,245 (GRCh38/hg38)

·         Size:11,304 bases

·         Orientation: Minus strand

·         chr9:132,575,221-132,586,441 (GRCh37/hg19)

·         Size:11,221 bases

·         Orientation: Minus strand

Chromosomal location:9q34.11

Chromosome 9 - NC_000009.12

Figure 1 shows chromosomal location. (Blast.ncbi.nlm.nih.gov, 2018)

Number of exon:5

Molecular mass: 37,813 Da

Gene type:Protein coding

Accession Number for the mRNA sequence: NM_000113, NM_000113.3

Accession number for the protein sequence: NP_000104

Size of mRNA transcript: 2080 bp

Size of the protein: 332 amino acid

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Torsin Family 1 Member A gene is a member of the AAA family of adenosine triphosphatases. TOR1A is protein-coding gene type. The main function of torsin-1A protein is to control protein folding, protein processing their stability and localization. They taking part in the reduction of misfolded protein aggregates.  TOR1A proteins regulates the recycling process of a synaptic vesicle, managing the stability of STON2 proteins which work out together with the COP9 signalosome complex. Torsin - 1A helps to control nuclear polarity by the connection of cytoskeleton together with the nuclear envelope. That mechanism is also important in cell movement especially for neurons and for nuclear envelope integrity. Proteins take part in the regulation of the subcellular location of multipass protein membrane, for example, SLC6A3 dopamine transporter. That regulation of SLC6A3 can lead to modulation of dopamine neurotransmission. Ubiquitous gene expression is found in thyroid (RPKM 14.8), urinary bladder (RPKM 12.7) and 25 other tissues.  Torsin - 1A in the endoplasmic reticulum verify the quality of protein assembly to reduce the number of misfolded proteins. Alternative splicing for a gene TOR1A is gene TOR1B.