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While smallpox and chickenpox have similar symptoms, there are still key differences. Smallpox has been eliminated completely, yet chickenpox is still around. Chickenpox consists of itchy rashes and fever, just like smallpox, but is a lot more mild. Most who are infected with chickenpox survive with a few simple scars, while 3 out of 10 who were infected with smallpox did not survive at all.

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1. It has been used as a weapon in war. British forces gave American Indians blankets contaminated with smallpox during the French and Indian Wars (1754 to 1767) and it was employed as a biological weapon. The Soviet Union developed variola in the 1980s as an aerosol biological weapon and prepared tons of virus-filled material for intercontinental ballistic missile delivery.
2. Smallpox has been eradicated in the United States for nearly 80 years with the last natural outbreak occurring in 1949. However, it was not until 1980 that the World Health Assembly declared its elimination to be worldwide.
3. Due to the lack of treatments for smallpox, it killed 30 percent of those affected.

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The majority infected by Smallpox ranged from infancy to late teens. However, it did negatively affect the older generations, as well. While those affected by it in their young ages survived, an older person who was infected was less likely to survive.

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While the origin of smallpox is unknown, findings of similar rashes on mummies suggest it has been around for several thousand years. The earliest written record of a smallpox-like disease can be traced back to 4th century China, as well as 7th century India.

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Prevention of smallpox consists of being vaccinated. The smallpox vaccination aids in the body's development of smallpox immunity. The vaccine is created using the vaccinia virus, a smallpox-related "pox" virus. In contrast to many other vaccines, the smallpox vaccine contains the "live" vaccinia virus.

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There is no existing cure for smallpox. In July 2018, the U.S. Food and Drug Administration (FDA) approved tecovirimat (also referred to as ST-246 or its brand name Tpoxx) as the first drug with an indication for treatment of smallpox. Those affected may also get the smallpox vaccine in order to relieve their symptoms.

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There are many different ways to spread this disease. Airborne respiratory droplets (coughing or sneezing), skin to skin contact, and unclean needles are responsible for being the most common mode of transmission.

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Symptoms of the disease include extensive rashes, lesions, high fever, chills, headaches, vomiting, malaise, and even in extreme cases, blindness.

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Smallpox is a disease caused by Variola Major and Variola Minor which causes lesions on the body of those it affects. It is one of the deadliest diseases known to humanity and is believed to have killed millions of people worldwide.

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Although there are two pathogens responsible for the disease known as Smallpox, it is Variola Major that I will be focusing on. While Variola Major and Variola Minor both cause Smallpox, Variola Major is responsible for a larger number of cases. It is part of the orthopoxvirus family.