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As kidney function declines, the body retains waste products in the blood (a condition called uremia). This affects many body systems and often causes feelings of tiredness.

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Waste buildup in the blood (uremia) can irritate the digestive tract and affect appetite and the sensation of nausea or vomiting.

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The kidneys help regulate sodium and water balance. When they're not working properly, excess salt and fluid build up, leading to fluid retention and visible swelling, especially in the lower extremities.

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In advanced CKD, phosphate levels rise in the blood, and waste products accumulate in the skin, leading to persistent itching.

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Due to Fluid Buildup in the Lungs,

Damaged kidneys can’t get rid of excess fluid properly.

That extra fluid can leak into the lungs, making it hard to breathe

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Damaged kidneys can't regulate blood pressure properly and may produce too much renin, a hormone that raises blood pressure. Also, fluid overload contributes to elevated pressure.

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1. Urinating (peeing) more often at night

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1. Urinating (peeing) more often at night

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Usually happens at the early stages of CKD

The kidneys start losing their ability to concentrate urine properly.

As a result, they produce more dilute urine, which leads to more frequent urination, especially noticeable at night (nocturia).