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This was the very first appearance of Anodyne the symbiote. I had commissioned the artist Sean Izaakse in 2007 to help me create an original symbiote medic hero and this image was a rough sketch of Anodyne. The funny thing about this sketch is that while ultimately we did away with the belt in the final design I do regret not keeping a belt of some kind for his design.

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The first Anodyne (mk II) by Sean Izaakse

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The first Anodyne (mk II) by Sean Izaakse

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With this, the second draft of Anodyne's first design, Sean figured out the perfect design for the hips and gloves but it was the third pass where the design came through with true Anodyne but this is close.

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Anodyne the Symbiote Medic by Sean Izaakse

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Anodyne the Symbiote Medic by Sean Izaakse

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Here's the final design artist Sean Izaakse created with my help for my symbiote medic OC named Anodyne. This is likely what many folks recognize as Anodyne and it was his look for more than a decade. Many folks say that he looks like Deadpool and I'm not saying that's totally off base but I think this design has more in common with Spider-Man, especially the hip slashes and angular eyes. Key to this final version was the inclusion of his sonic inhibitor collar that keeps his symbiote under control.