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Use a comma with a coordinating conjunction (and, but, yet, so, or, nor, for). When you join two complete sentences with a coordinating conjunction you must place a comma before the coordinating conjunction.
Run-on: My professor read my paper she said it was excellent.
Correction: My professor read my paper, and she said it was excellent.

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A semicolon is used to separate two complete sentences. When you use a semicolon you  use a conjunctive adverb (such as, however, or consequently). You can also use a transitional phrase (such as, for example, or on the other hand)

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There are two complete sentences:
Sentence 1: I love to write papers.
Sentence 2: I would write one every day if I had the time.

A run-on sentence occurs when two or more complete sentences are connected improperly.
-I love to write papers I would write one every day if I had the time.

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A comma splice is used to correct run-on sentences using a comma. Example: Participants could leave the study at any time, they needed to indicate their preference.

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A run-on sentence is a sequence of two or more complete sentences.

A complete sentence is complete when has a subject and a verb.

A run-on sentence is not separated by a period, semicolon, or a comma joined by a conjunction, but it should be.

The following are conjunctions that combine two complete sentences together:
For
And
Nor
But
Or
Yet
So

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Link to the problems.

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One way to fix a run-on sentence is to separate it into smaller sentences using a period.
Examples:
I love to write papers. I would write one every day if I had the time.

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Use a semicolon (or, in some cases, a colon). You can use a semicolon alone or with a transitional expression (e.g., however, at any rate, in contrast, as a result, etc.).
Run-on: My cat meowed angrily I knew she wanted food.

Correction: My cat meowed angrily; I knew she wanted food.

Correction with a transitional expression:

My cat meowed angrily; therefore, I knew she wanted food