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1. How is the resting membrane potential of a neuron established? Knowing this how can one easily manipulate it? (5pt)

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1. How is the resting membrane potential of a neuron established? Knowing this how can one easily manipulate it? (5pt)

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NOTE: Na/K-ATPase pump is cited from lecture dated 1.21.18. Concentration gradient and selective permeability cited from lecture dated 1.16.18 (slide 7)

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2. What are 2 constants that effect the spread of electric potentials through passive membranes? Explain what information they  can tell you about a neuron. (5pts)

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2. What are 2 constants that effect the spread of electric potentials through passive membranes? Explain what information they  can tell you about a neuron. (5pts)

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Depolarization:
Hyperpolarization:
Excitation:
Inhibition:
Reversal potential:

NOTE: Cited from lecture dated 1.21.18 and Wiki (for reversal potential)

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4. Here is a voltage plot of an action potential. (5pts)

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4. Here is a voltage plot of an action potential. (5pts)

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Materials cited from lecture dated 1.18.18

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5. What portion of the above voltage plot plays an important role in determining the ability of a neuron to fire another action potential? Provide an example of how a neuron can manipulate this phase to decrease its firing rate? (5pts)

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5. What portion of the above voltage plot plays an important role in determining the ability of a neuron to fire another action potential? Provide an example of how a neuron can manipulate this phase to decrease its firing rate? (5pts)

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Cited from lecture dated 1.21.18

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6. Here is an I/V plot for a novel cation channel (3pts).

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6. Here is an I/V plot for a novel cation channel (3pts).

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At what potential does the channel begin to activate?
Where is this channels reversal potential?
Which one of the following channels is best described by this plot?

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7. Propose a mechanism for the effect of muscarine on this neuron below. (2pts)

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7. Propose a mechanism for the effect of muscarine on this neuron below. (2pts)

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Cited from lecture dated 1.25.18

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8. Below is a recording of a train of action potential that were recorded a different distances along the dendrite following a somatic current injection. Why does the amplitude of the action potentials diminish so rapidly as you travel further away from the soma? (5pts)

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8. Below is a recording of a train of action potential that were recorded a different distances along the dendrite following a somatic current injection. Why does the amplitude of the action potentials diminish so rapidly as you travel further away from the soma? (5pts)

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9. UPDATED List 5 properties that are associated with a ligand-gated channel (think simple, feel free to draw a diagram and provide labels to help you)? (5pts)

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9. UPDATED List 5 properties that are associated with a ligand-gated channel (think simple, feel free to draw a diagram and provide labels to help you)? (5pts)

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Cited from lecture 2.1.18

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10. Using the graph below, illustrate the I/V curves for the following types of channels: (3pts)

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10. Using the graph below, illustrate the I/V curves for the following types of channels: (3pts)

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A. Inward rectifying channel
B. Outward rectifying channel
C. Non rectifying channel
Cited from lecture 1.30.2018

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11. Describe channel desensitization. (2pts)

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11. Describe channel desensitization. (2pts)

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Cited from lecture 1.30.18

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12. Propose two different models for how mechanosensitive channels can be gated (2pts)

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12. Propose two different models for how mechanosensitive channels can be gated (2pts)

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Cite from lecture dated 2.1.18

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13. Provide a diagram illustrating each type of inhibition of a ligand-gated channel. (3pts)

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13. Provide a diagram illustrating each type of inhibition of a ligand-gated channel. (3pts)

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A. Competitive inhibition
B. Noncompetitive inhibition
C. pore block
Cited from lecture dated 2.6.18 & from Wikispaces