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Curley's wife is described by the narrator.  "She had full, rouged lips and wide-spaced eyes, heavily made up. Her fingernails were red. Her hair hung in little rolled clusters, like sausages. She wore a cotton house dress and red mules, on the in-steps of which were little bouquets of red ostrich feathers" (31). This is a woman who attends to her appearance, who is dressed inappropriately for farm life, suggesting she desires attention and does not fit in.

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George and Slim agree that men you travel around in isolation become mean. George says, "I seen the guys that go around on the ranches alone. That ain't no good. They don't have no fun. After a long time they get mean. They get wantin' to fight all the time." Slim agrees that "they get so they don't want to tlak to nobody" (41).

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Crooks is isolated because of his race and his disability, and he shows a lack of compassion for Lennie, when he lashes out and says, "You got no right to come in my room. This here's my room [...] I ain't wanted in the bunkhouse, and you ain't wanted in my room" (68).

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Curley's wife lashes out at Crooks, saying she could have him hung (81). She is isolated because she is the only woman on the farm, and she lacks compassion for Crooks, who is also isolated.

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Theme statement:
Everyone needs human contact, friendship, and community, and people who are isolated from others become selfish and uncaring.

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Curley's wife is lonely and in need of companionship.  She says to Crooks, Lennie, and Candy, "Think I don't like to talk to somebody ever' once in a while?  Think I like to stick in that house alla time?" (77).  (indirect characterization)