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Glass, Nancy. Autonomic Nervous System Part 1 and Part 2. Pharmacology for Health Professionals. 02 Feb 2021. ACC. PowerPoint Presentation.

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Receptor: cholinergic
MOA: blocking drug (competitive antagonism), increases HR, decreases vagus nerve activity, digestion/urination (slow), mydriasis, GI/motility (decreases), bronchodilation
Drugs: atropine
dicyclomine (Bentyl®)
ipratropium bromide (Atrovent®)

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Receptor: cholinergic
MOA: inhibits acetylcholinesterase (Increases ACH)
Drugs: neostigmine (Prostigmin®)

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Receptor: muscarinic
MOA: mimics ACH, pupil constriction, IOP (decreased), prevents constipation/urination
Drugs: acetylcholine

pilocarpine (Pilocar®) bethanechol (Urecholine®)

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Receptor: beta-1 & beta-1
MOA: decreases (contraction, HR, cardiac output, conduction) --> decreases BP, bronchoconstriction
Drugs: nadolol (Corgard®)

propranolol (Inderol®)

timolol (Blocadren®)

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Receptor: beta-1
MOA: decreases (contraction, HR, cardiac output, conduction) --> decreases BP
Drugs:  atenolol (Tenormin®)

metoprolol (Lopressor®)

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Receptor: beta-2
MOA: bronchodilation, uterus (relaxation)
Drugs: formoterol (Foradil®)

albuterol (Proventil®/Ventolin®)

terbutaline (Brethine®)

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Receptor: d-1 (low dose), beta-1 (moderate dose), alpha-1 (high dose)
MOA:
low dose-vasodilation and increased renal flow
moderate dose-increases contraction and cardiac output
high dose-vasoconstriction
Drugs: dobutamine

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Receptor: alpha-1
MOA: smooth muscle (relaxation), vasodilation (lower BP), ureters (relaxation), urine flow (increased)
Drugs: prazosin (Minipress®)

terazosin (Hytrin®)

doxazosin (Cardura®)

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Receptor: alpha & beta
MOA-
alpha-1: vasopressor-vasoconstriction (increases BP)
beta-1: cardiac stimulant
beta-2: bronchodilation
Drugs: epinephrine (Adrenalin ®)

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Receptor: alpha-1
MOA: smooth muscle (contraction), vasoconstriction (increases BP), vasoconstriction nasal passages
Drugs: 1. ephedrine
2. phenylephrine (Neo-Synephrine ®)

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Relaxation

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Contraction

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Bronchoconstriction

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Constriction (miosis)

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Increased

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Decreases:
Heart Rate
Conduction
Contractility

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Contraction

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Relaxation

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Bronchodilation

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Dilation (mydriasis)

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Decreased

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Increases:
Heart Rate
Conduction
Contractility

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Vasoconstriction (most of them)
Vasodilation (coronary and skeletal muscle arteries)

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Release of EPI

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ganglia of parasympathetic and sympathetic nerves (synapse area)

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Location: cardiac, smooth muscle and glands at parasympathetic postganglionic nerve endings

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Location: smooth muscle, uterus, lungs, skeletal muscle blood vessels

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Location: heart

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Location: adrenergic nerve endings

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Location: glands, smooth muscle, eyes, most arteries/veins

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sympathetic postganglionic fiber

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ganglion

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ganglion & postganglionic nerve endings

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postganglionic nerve endings

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adrenal medulla

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"Visceral"

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"cholinergic"

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"adrenergic"