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The circulatory system pumps blood through the body. It use's the heart, the arteries, and the veins to transport blood through your body.

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The nervous system tells us what to move in our body. We may feel pain, cuts, and bruises. It uses the brain, the spinal cord and nerves.

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Painful swelling of the hands and feet. It is more common know as dactylitis
Fatigue or fuzziness from anemia
Yellowish color of the skin (jaundice)
White of the eyes (icteris)

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In the picture below red blood cells are in a circle which will allow the blood cell to be able to flow through the body easily. The sickle cell on the other hand; the shape of the sickle cell can block off the path the blood flows through which is very dangerous.

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It is a self regulating process that the biological system needs to maintain stability while adjusting to conditions for survival. If successful we live, if not ensured death.

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The nervous system maintains Homeostasis by controlling and regulating the other parts of the human body. The circulatory system must maintain the homeostasis system if it does not for a 1/2 of a min it can cause a lot of damage to the human body.

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They do there own thing but they both keep the homeostasis maintained. The circulatory system has to keep the heart beating. When the heart is beating the nervous system has to tell the body what to do to keep the homeostasis from failing which will equal death.

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The sickle cell and the red blood cell are doing the same thing. They both carry oxygen.

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The blood line can get clots because of the sickle cells when red blood cells do not. The red blood cells carry more oxygen than the sickle cell. Also the red blood cells carry nutrients but sickle cell can not.

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The nervous system is affected from sickle pain by pain. The sickle cell shapes can cause clots in the blood vessels. These clots can happen anywhere in the body.
The circulatory system is a major organ affected by sickle cell. Affects from it are asthma, pneumonia, and when the blood flow is cut off from the lungs there could be infection, or it can cause acute chest syndrome which is fever, chest pain, cough, and x-ray changes.

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DNA affect your body to keep you alive by proteins. This happens through the process of protein synthesis. The process is when DNA unfolds it self from the double helix and then unzips to make a copy of that one side of the code, which becomes mRNA. mRNA goes out from the nucleus to the cytoplasm, which then goes to the ribosomes. Then tRNA reads the messenger mRNA and then the ribosomes start making proteins while amino-acids tells them what they are going to become. When all the proteins are made the amino acids tell the protein what type of cell they will become. Then finally the protein go off to where they need to go for that cell to function.

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http://www.nhlbi.nih.gov/health/health-topics/topics/sca/signs
http://www.livescience.com/22665-nervous-system.html
http://www.britannica.com/science/homeostasis
http://www.mhhe.com/biosci/genbio/maderbiology/supp/homeo.html
http://cardiosystemweebly.weebly.com/maintaining-homeostasis.html
http://www.livestrong.com/article/128264-systems-body-affected-sickle-cell/