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On Earth you can't just shut it down at it's core, it's not machine. Though what if someone is a traitor and shuts the mainframe off?

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where did they get all their resourses from in the first place

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Will clouds form because of the moisture, allowing the water cycle to happen?

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what their government like

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whats their type of government?

where do they get all of their resources in the first place?

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How would they contact Earth, there is so much space between them, sometimes you can't even contact people on the other side of the world, how about ANOTHER world?

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How do they power everything ?

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what power source do they use

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What if they run out of energy, will they just be stranded with no delivered resources?

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how do they keep it in orbit

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What happens if all the plants and animals dye from some cause. Would they have to go back to earth?

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How do they keep it in orbit?

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how dose their technology work

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How will they select who gets to go on this colony

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How will there be day and night, artificial revolutions around the Sun?

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What technology are they using?

How do they keep the  animals alive?

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How shall the air be filtered if there is (probably) no trees?

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The amount of water they have

How to get the air to the colony

How they get the gravity to stay put

The type of food that they eat

How the toilets would work

How the would keep the population controlled

The amount of doctors that they would need

Any asteroids or space rock that would fly at them

Garbage disposal

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They will probably have a lack of oxygen and fresh air, so unless Earth is providing them (which will make Earth loose these resources), how are they going to get these musts for the human-kind.

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How do they have enough food to eat?
Where do they get the water?
What if you need fuel, it is hard to transport it from home.
how do you keep the air in there?
How do they make artificial gravity?
How do they plant all those plants?
How do they make ketchup or ranch?
How would the toilets work?
How would you keep the population?
How many doctors would they have?
Asteroids or space rocks can crash.
Where does the garbage go?

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how do they intensify the gravity on mars
how dose their technology work
What happens if all the plants and animals dye from some cause. Would they have to go back to earth?