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Glivec 400 mg tablets : Product information

What is Glivec?

Glivec Novartis 400 mg tablets are a medicine containing an active substance called imatinib. This medicine works by inhibiting the growth of abnormal cells and belongs to the drug class of BCR-ABL tyrosine kinase inhibitors. The drug is used to treat such ailments like:

1. Acute Lymphoblastic leukemia

2. Chronic myelogenous leukemia

3. Chronic Eosinophilic leukemia and several other kinds of leukemia

4. Chronic myeloid leukaemia (CML)

Glivec 400 mg tablets can also be used as a treatment for adults for:

- Myelodysplastic/myeloproliferative diseases (MDS/MPD). These are a group of blood diseases in which some blood cells start growing out of control. Glivec inhibits the growth of these cells in a certain sub-types of these diseases.

- Hypereosinophilic syndrome (HES) and/or chronic eosinophilic leukaemia (CEL). These are blood diseases in which some blood cells (called eosinophils) start growing out of control. Glivec inhibits the growth of these cells in a certain sub-types of these diseases.

- Dermatofibrosarcoma protuberans (DFSP). DFSP is a cancer of the tissue beneath the skin in which some cells start growing out of control. Glivec inhibits the growth of these cells.

- Gastrointestinal stromal tumours (GIST). GIST is a cancer of the stomach and bowels. It arises from uncontrolled cell growth of the supporting tissues of these organs.

As a member of the protein tyrosine kinase inhibitor, this drug is useful in stopping the cancer spread to other parts of the body. It does this simply by preventing the action of some abnormal protein, especially those responsible for cancer cells growth.

How to take

Patients must take it according to the instructions provided to them by their doctor, but it is normally taken orally.

Glivec is always taken with a meal. If you are finding it hard to swallow the drug, you can dissolve it in water, stir it until it is well dissolved. You can also stir it with apple juice

Most patients often start from 400 mg or 600 mg, but that depends on the patient's condition. If your doctor prescribes 400 mg then it has to be taken once daily. If on the other hands that he prescribes 600 mg, then you take 400 mg once, as well as 2 tablets of 100 mg once daily. This is the usual prescription for patients diagnosed with CML.

If the patient is diagnosed with GIST, such a patient should always start with 400 mg daily. Whether you are GIST or CML patients, the prescription could be varied, but that depends on how you respond and that is why the prescription could increase to 800 mg, which means that you can take up to 2 tablets of the drug every day.

If you are suffering from Ph-positive ALL: the treatment should often start with 600 mg and this has to be taken 400 plus 2 of 100 mg once every day.

In the same way for patients suffering from MDS/MPD, they can always start from 400 mg daily. For patients diagnosed with HES/CEL, they can often start with a dosage of 100 mg once daily. If there is need, the doctor can increase the dosage to 400 mg and this depends on how you respond to treatment.

For patients treated of DFSP, they can always take a dose of 800 mg daily. It has to be split 400 mg in the morning and another 400 mg in the evening.

As said earlier, prescriptions for children and adolescents are not the same. The quantity depends on the medical condition of the patients as well as the height and body weight. The overall dosage would not be more than 800 mg for CML patients and 600 mg for Ph+ALL.

How long you take it depends on your doctor's prescriptions. As your doctor monitors the drug performance or your response to treatment, they may adjust the dosage. The most important thing is that you take that drug as prescribed by your doctor. All instructions given to you must be followed.

You should avoid using it on self-medication. Before you change the dosage, it must be with your doctor's approval.

Side effects

However, you should know that there is a possibility of side effects as you take that drug. Some possible side effects include vomiting and nausea, joint pain, increased perspiration, feeling anxious, watery eyes, and so on.

If you begin to experience any of these signs, or any other sign after taking this tablet, you should inform your doctor promptly.
Pregnancy
However, there are certain precautions. If you are pregnant, there is the fear that the tablet may not be suitable for an unborn baby and because of that, it is not recommended for pregnant women. Moreover, such women are discouraged from handling this tablet, because of the fear that it could be absorbed to the body through the skin.

Moreover, breast-feeding mothers are discouraged from using the tablet. If you begin to experience an allergic reaction after taking the drug, do not hesitate for medical attention.

There are certain symptoms you should watch out for. The most common among them are hives, skin rashes, face or limbs swelling, difficulty in breathing and swallowing.

More uses for Glivec

It is use in the treatment of adult and children suffering from Chronic myeloid leukaemia CML. This is a peculiar kind of cancer and can be found in the white blood cells. White cells are important because the human body rely on them to fight infection. There could be a situation where the abnormal white cells start showing strange behaviors by growing out of control. When such an abnormal situation manifests in children and adults, Glivec 400 mg can be used to address the problem.

Furthermore it can be used for adults suffering from Ph-positive ALL. This is another name for Philadelphia chromosome positive acute lymphoblastic leukaemia. This is another type of cancer found in the white cells. When it attacks the white cells, it inhibits its ability to deal with foreign bodies that interfere with human health. This medical condition often manifests when the white cells develop strange behavior and begin to grow out of control. This is a rare medical situation.

Anytime the symptoms begin to manifest, Glivec 400 mg is used to treat the condition. This is effective in adults. There is no evidence that this medication is applied to children.

Another use for an adult is a medical condition known as myelodysplastic/myeloproliferative diseases. This is regarded as a grouped blood cells. A situation can manifest where some of these grouped blood cells start to grow out of portion, and out of control.

If this condition manifests in adults, Glivec 400 mg can be used to address this condition. This is not a routine condition. It is rare medical situation.

The next medical condition, which doctors have always prescribed Glivec 400 mg include "Hypereosinophilic syndrome (HES) and/or chronic eosinophilic leukaemia (CEL)". This is another situation where blood cells called eosinophils decide to grow out of control. This is a blood disease and it can manifest among adults.

If patients are given Glivec 400 mg, it would prevent the growth of these dangerous cells, and the diseases associated with it.

Moreover, the formulation can be used to treat another condition known as Dermatofibrosarcoma protuberans (DFSP). This is a rare cancer and it can be found beneath the human tissue in the skin. Here some cells developed a problem, because they have grown out of proportion, and out of control. It can lead to a disease.

Glivec can be used to address the problem among adult patients. These are the major health conditions medical experts have used this formulation for. There could be other medical conditions that this medication can help as research and trials are still ongoing.

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