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Hereditary Hemochromatosis is  an inherited disorder in which there is too much iron in the body (iron overload).
The disease causes your body to take in too much iron from your food.

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It is caused by genetic mutations. The gene HFE is most often the cause of hemochromatosis. You inherit one HFE gene from each of your parents. The HFE gene has two common mutations, C282Y and H63D.
If you have this disease, there is a possibility that you might pass this gene onto your children. Even if you only have one of the mutated genes, there is still possibility to pass this gene onto your children. Your child then won't develop the disease unless both you and your partner have at least one of the genes.

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It is very common in Caucasians in the United States.  It affects about 1 in 6 people.
This type of hemochromatosis is be far the most common type.

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Too much iron is toxic.

A hormone called hepcidin, secreted by the liver, normally controls how iron is used and absorbed in the body, as well as how excess iron is stored in various organs. In hemochromatosis, the normal role of hepcidin is disrupted, causing your body to absorb more iron that it needs.

This excess iron is stored in major organs, especially your liver. Over a period of years, the stored iron can cause severe damage that may lead to organ failure and chronic diseases, such as cirrhosis, diabetes and heart failure. Though many people have faulty genes that cause hemochromatosis, only about 10 percent of them develop iron overload to a degree that causes tissue and organ damage.

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What Happens When You Have The Mutated Gene?

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What Happens When You Have The Mutated Gene?

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One mutation replaces the amino acid cysteine with the amino acid tyrosine at position 282 in the protein's chain of amino acids (written as Cys282Tyr or C282Y).
The Cys282Tyr mutation prevents the altered HFE protein from reaching the cell surface, so it can't interact with certain receptors. As a result, iron regulation is disrupted, and too much iron is absorbed from the diet.

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Hereditary hemochromatosis is present at birth. Most people don't experience signs and symptoms until later in life,  usually between the ages of 50 and 60 in men and after age 60 in women. Women are more likely to develop symptoms after menopause, when they no longer lose iron with menstruation and pregnancy.

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Some treatments include removing blood from your body on a regular basis,
Hereditary Hemochromatosis is not curable. The patient will have to be monitored and treated for the rest of their life.
Untreated, this disease can be fatal.

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http://www.americanhs.org/
https://ghr.nlm.nih.gov/condition/hereditary-hemochromatosis
https://www.genome.gov/10001214/learning-about-hereditary-hemochromatosis/
https://www.mayoclinic.org/diseases-conditions/hemochromatosis/symptoms-causes/syc-20351443

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The appearance and progression of symptoms can be affected by environmental and lifestyle factors such as the amount of iron in the diet, alcohol use, and infections.
The earliest symptoms are not as specific to the disease. They include; fatigue, joint pain, abdominal pain, and loss of sex drive.
Later symptoms include; arthritis, liver disease, diabetes,  heart issues, and skin discoloration.
Other symptoms include; hair loss or hair thinning, a possibility for liver cancer, weight loss, headaches and colds or the flu,