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Induction Session 20-09-18- Mitra Tavakoli- Group 9

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https://sites.google.com/exeter.ac.uk/integrated-human-physiologyv2/induction?authuser=1

https://vle.exeter.ac.uk/course/view.php?id=7068

https://padlet.com/m_tavakoli/cszsrlw7uapk

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Useful Resources: Guyton Physiology : https://encore.exeter.ac.uk/iii/encore/record/C__Rb3370296?lang=eng&suite=def

Medical Sciences: https://encore.exeter.ac.uk/iii/encore/record/C__Rb2447297?lang=eng&suite=def

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https://youtu.be/7Z7aeBCQwTQ
https://youtu.be/SVqSqPOcahY
https://youtu.be/ISpVjQSlml4
https://youtu.be/uYu-zvCXiV4
https://youtu.be/66iJfFevuRY
https://youtu.be/PAIFAf8aZ8I
https://youtu.be/rwZIT_N75Bs

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Informative study on hyperkalemia and the mechanisms of potassium filtration in the renal (and digestive) system

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Informative study on hyperkalemia and the mechanisms of potassium filtration in the renal (and digestive) system

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Lots of good information under "Renal mechanisms of potassium handling" subtitle!

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Checking your browser before accessing pmc.ncbi.nlm.nih.gov…

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This is a really useful and easy diagram of the RAAS system!

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The effect of Vitamin D on kidney function

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Acid base balance st kidney

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The Effect of Vitamin D on Kidney Function 

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The Effect of Vitamin D on Kidney Function 

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The effect of Vitamin D on kidney function

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Overview of some of the hormones involved in the digestive system

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Overview of some of the hormones involved in the digestive system

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E-Resource on macro and micronutrient absorption in the small intestine

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E-Resource on macro and micronutrient absorption in the small intestine

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Key Hormones in Regulation of Stomach Emptying

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how alcohol changes GI tract function 9 [Autosaved]

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e Resource

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Pharmacological Inhibition of Gastric Acid Secretion NC

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https://www.bbc.com/bitesize/guides/zxjcmsg/revision/4  ( related to question 1)

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Some of the enzymes and secretions in the GI tract

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Some of the enzymes and secretions in the GI tract

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23.4 The Stomach – Anatomy and Physiology

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Human Anatomy and Physiology is designed for the two-semester anatomy and physiology course taken by life science and allied health students. The textbook follows the scope and sequence of most Human Anatomy and Physiology courses, and its coverage and organization were informed by hundreds of instructors who teach the course.

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Table overview of the different types of white blood cells and their functions

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Table overview of the different types of white blood cells and their functions

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The function of the lymphatic system in regards to the immune system

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Link with different cells of the immune system

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Link with different cells of the immune system

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Home // Public Information // BiteSized Immunology // Cells

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Helpful video for overview of the immune system

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Helpful video for overview of the immune system

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https://youtu.be/qkIfYwnaYqc

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Chemical Mediators of Inflammation - Pharmacology - Veterinary Manual

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Useful information on lymphatic system and immune system!

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The Immune System Explained I – Bacteria Infection

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The main cell types involved in clearing viral infection

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Differences between virus and bacterial infections

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Differences between virus and bacterial infections

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https://youtu.be/p99keWXbcYs

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Via cytotoxic cells

When a virus infects a person (host), it invades the cells of its host in order to survive and replicate. Once inside, the cells of the immune system cannot 'see' the virus and therefore do not know that the host cell is infected. To overcome this, cells employ a system that allows them to show other cells what is inside them - they use molecules called class I major histocompatibility complex proteins (or MHC class I, for short) to display pieces of protein from inside the cell upon the cell surface. If the cell is infected with a virus, these pieces of peptide will include fragments of proteins made by the virus.

A special cell of the immune system called a T cell circulates looking for infections. One type of T cell is called a cytotoxic T cell because it kills cells that are infected with viruses with toxic mediators. Cytotoxic T cells have specialised proteins on their surface that help them to recognise virally-infected cells. These proteins are called T cell receptors ( TCRs). Each cytotoxic T cell has a TCR that can specifically recognise a particular antigenic peptide bound to an MHC molecule. If the T cell receptor detects a peptide from a virus, it warns its T cell of an infection. The T cell releases cytotoxic factors to kill the infected cell and, therefore, prevent survival of the invading virus ( Figure 1).

Viruses are highly adaptable, and have developed ways to avoid detection by T cells. Some viruses stop MHC molecules from getting to the cell surface to display viral peptides. If this happens, the T cell doesn't know there's a virus inside the infected cell.

However, another immune cell specialises in killing cells that have a reduced number of MHC class I molecules on their surface - this cell is a natural killer cell or NK cell for short. When the NK cell finds a cell displaying fewer than normal MHC molecules it releases toxic substances, in a similar way to cytotoxic T cells, which kill the virally-infected cell.

Cytotoxic cells are armed with preformed mediators. Cytotoxic factors are stored inside compartments called granules, in both cytotoxic T cells and NK cells, until contact with an infected cell triggers their release. One of these mediators is perforin, a protein that can make pores in cell membranes; these pores allow entry of other factors into a target cell to facilitate destruction of the cell. Enzymes called granzymes are also stored in, and released from, the granules. Granzymes enter target cells through the holes made by perforin.

Once inside the target cell, they initiate a process known as programmed cell death or apoptosis, causing the target cell to die. Another released cytotoxic factor is granulysin, which directly attacks the outer membrane of the target cell, destroying it by lysis. Cytotoxic cells also newly synthesise and release other proteins, called cytokines, after making contact with infected cells. Cytokines include interferon-g and tumour necrosis factor-a, and transfer a signal from the T cell to the infected, or other neighbouring cells, to enhance the killing mechanisms.

Via interferons

Virally infected cells produce and release small proteins called interferons, which play a role in immune protection against viruses. Interferons prevent replication of viruses, by directly interfering with their ability to replicate within an infected cell. They also act as signalling molecules that allow infected cells to warn nearby cells of a viral presence - this signal makes neighbouring cells increase the numbers of MHC class I molecules upon their surfaces, so that T cells surveying the area can identify and eliminate the viral infection as described above.

Via antibodies

Viruses can also be removed from the body by antibodies before they get the chance to infect a cell. Antibodies are proteins that specifically recognise invading pathogens and bind (stick) to them. This binding serves many purposes in the eradication of the virus:

Firstly, the antibodies neutralise the virus, meaning that it is no longer capable of infecting the host cell.

Secondly, many antibodies can work together, causing virus particles to stick together in a process called agglutination. Agglutinated viruses make an easier target for immune cells than single viral particles.

A third mechanism used by antibodies to eradicate viruses, is the activation of phagocytes. A virus-bound antibody binds to receptors, called Fc receptors, on the surface of phagocytic cells and triggers a mechanism known as phagocytosis, by which the cell engulfs and destroys the virus.

Finally, antibodies can also activate the complement system, which opsonises and promotes phagocytosis of viruses. Complement can also damage the envelope (phospholipid bilayer) that is present on some types of virus

Immune responses to viruses © The copyright for this work resides with the author

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Via cytotoxic cells When a virus infects a person (host), it invades the cells of its host in order to survive and replicate. Once inside, the cells of the immune system cannot 'see' the virus and therefore do not know that the host cell is infected.

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Really useful step by step process on inflammation

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Thought this has a really good overview of how the immune system fights viral infections

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The general principles of immunology are presented in Chapter 1. The present chapter discusses viral activation of immunity, humoral and cell-mediated immunity, virus-induced immunopathology, and roles of immune functions during viral infections.

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Cells involved in fighting a bacterial infection

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http://www.bbc.co.uk/science/0/22028517

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eResource about Factors affecting Glomerular filtration (pressures)

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eResource about Factors affecting Glomerular filtration (pressures)

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I would recommend to download the presentation to make the most out of it.