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He began his career in the Philippines working as a designer and storyboard artist. Later he would then move to the United States, where he joined the animation industry in Los Angeles. His passion for storytelling and his strong work ethic were key factors in his rise to international fame. His ability to infuse emotion and depth into animated stories made him a sought-after talent in the global animation industry. He started working with DreamWorks on films like "The Prince of Egypt" and "The Road to El Dorado." He later joined Pixar Animation Studios, where he made significant contributions to films like "Finding Nemo," "Ratatouille," and "Up." He co-directed the Academy Award-winning film "Inside Out" and is known for his work as a story artist, designer, and director.

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His first career in the Philippines was an architect before shifting to animation. He worked for a local animation studio before moving to the United States in the early 1990s. His architectural background gave him a unique perspective on environment and layout design, which became his specialization. His distinct style and expertness in creating immersive animated worlds helped him secure opportunities in major international studios. Serrano worked for various top-tier animation studios, including Walt Disney Animation Studios and Sony Pictures Animation. He contributed to iconic films like "Lilo & Stitch," "Brother Bear," and "Big Hero 6" at Disney, and "Cloudy with a Chance of Meatballs" and "Hotel Transylvania" at Sony studios.

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She studied at the California Institute of the Arts (CalArts), a school known for producing some of the world’s top animators. She started her career as an intern at Walt Disney Animation Studios. Her background in storytelling and her ability to bring complex characters and narratives to life made her an invaluable asset to Disney. She quickly rose through the ranks at Disney, becoming a story artist and later head of story on major projects like "Zootopia" and "Ralph Breaks the Internet." She played a key role in the development of "Zootopia," which won the Academy Award for Best Animated Feature.