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Further damage to kidney, liver and small intestine over time

Bowel complaints

Can produce toxic substances that lead to serious illness

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medical history

family history

physical exams

lab tests

DNA tests from blood samples

Liver biopsy to see aldolase activity

Fructose tolerance test

HFI is inherited in an autosomal recessive way which means mutations are present. So basically, the parents of someone who has HFI both carry a recessive, mutated gene, but since it’s recessive they usually won’t show any symptoms of HFI.

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Convulsions

Sleepiness

Irritability

Jaundice (yellow skin/ eyes)

Vomiting

Problems after eating foods that contain fructose or sucrose

A person’s liver and spleen may be enlarged

Low blood sugar

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HFI is an inherited disorder that affects a person's ability to digest sugar fructose. This is a genetic disorder that occurs when there are mutations on the ALDOB gene. This disorder happens when the body is missing an enzyme called aldolase B (the substance needed to break down fructose). Fructose is found in fruits and sweeteners. If a person without this enzyme eats fructose, complicated chemical changes occur. And the body is not able to change its stored form of sugar into glucose. Because of this, blood sugar level falls and dangerous substances build up into the liver. The disorder affects the liver, small intestine and the kidney.