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Kim's office: 7-7665

Cell: 412-855-1375

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No significant difference in coronary artery lesions after 6 months between IVIG + high-dose aspirin and IVIG + low-dose aspirin groups - but no changes to AHA guidelines or to our institutional practice yet! A larger study from China is coming!

Pearls: High-dose aspirin for anti-inflammatory effects; low-dose aspirin for anti-platelet/thrombotic effects.

Risks of aspirin: Reye's syndrome, drug toxicity, anemia

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Among children hospitalized for croup, children who received >1 dose of dexamethasone had a longer LOS compared with children who received 1 dose of dexamethasone; however, there was no statistically significant difference in the 30‐day return to ED visits.

Consideration: dexamethasone dose should last around 24 hours.

Side effects of dex: hyperglycemia, irritability, difficulty sleeping, hypertension, (suppression of adrenals on prolong courses)

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-Study of children presenting to ED with suspected CAP: Only 3 physical examination findings (wheezing, retractions, respiratory rate) had acceptable interrater reliability (IRR)

-Other examination findings that are typically considered important in making the clinical diagnosis of pneumonia (eg, crackles/rales and decreased breath sounds) demonstrated poor to moderate IRR.

Take home: Reliability of many exam findings in CAP is not great; but the fair reliability of wheezing, retractions, and RR must be considered in the clinical management and research of pediatric CAP.

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Risk factors for severe disease among  children hospitalized with RSV

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Risk factors for severe disease among  children hospitalized with RSV

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Retrospective cohort study that stratifies different risk factors in children of different age with severity of RSV-associated acute respiratory infections. I thought it was compelling that asthma and neurodevelopmental disease were associated with increased risk of severe disease.

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PediactricsInReview is a great resource!

ESR: rises within 1-2 days, normalizes over weeks

CRP: rises within 4-6 hours, peaks in 2 days, normalizes within 7-10 days. Also check units as different hospitals use different units.

PCT: rises within 2-3 hours, peaks in 1-2 days, normalizes in 2-3 days; >0.5 ng/mL may indicate bacterial infection

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NORD: https://nordsummit.org/?utm_source=RareDiseases.org+Homepage+Banner&utm_medium=banner&utm_campaign=nord_summit_2025&utm_id=NORD+Summit+2025

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NORD® Rare Diseases and Orphan Products Breakthrough Summit.®

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Shape the future of rare disease treatments, research and policy at the NORD® Rare Diseases and Orphan Products Breakthrough Summit.® Together, we can advance equity and innovation for the more than 30 million Americans – and more than 400 million people worldwide – with rare diseases!