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First-line antihypertensives in the JNC 8 guidelines for the treatment of hypertensionLoop diuretics. Three main types:

Potassium-sparing diuretics

Thiazides and thiazide-like diuretics

Loop diuretics

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Inhibits ACE (which converts angiotension I to angiotension II). This results in blood vessels remaining dilated which keeps blood pressure under control. It also prevents secretion of aldosterone which causes our bodies to retain water and sodium making our blood pressure high.

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Do not suddenly stop taking medication. If you do, it can lead to rebound hypertension !!! Change positions slowly & sit on sit of bed for a few minutes before standing (to prevent orthostatic hypotension)

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avoid potassium-containing foods & pills

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Orthostatic HYPOtension

Dizziness

Angioedema

Cough (dry)

Elevated potassium (K+)

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Seven main categories of drugs to treat hypertension

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Seven main categories of drugs to treat hypertension

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1. Diuretics

2. Adrenergic drugs

3. Vasodilators

4. Angiotensin-converting enzyme (ACE) inhibitors

5. Angiotensin II receptor blockers (ARBs)

6. Calcium channel blockers (CCBs)

7. Direct renin inhibitors

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Examples of these medications include Benazepril or lisinopril.

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Treats high blood pressure and heart failure by widening the walls of the blood vessels, preventing them from narrowing and keeping the muscles from tightening. Thus, allows greater blood flow to all organs.

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Direct vasodilation of arterioles

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HTN, Heart failure w/ reduced ejection fraction

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Welcome to our Antihypertensive Drugs Padlet! Please follow the instructions below to complete the activity. If you have any questions, please ask your instructor for help. • Add a post to the padlet with your assigned antihypertensive drug class • Include a clear, detailed explanation of how the drug works to lower blood pressure. Create a post explaining everything you can remember about your assigned antihypertensive drug class, including a diagram or animation. • Attach a diagram or animation that illustrates the drug's mechanism of action, primary contraindication or something that will make it memorable. • Be prepared to discuss the various mechanisms in class.