# data[].attributes.body
Grouping:

Experimental Autoimmune Encephalomyelitis (EAE) induction in 0 M

Two control groups: age-matched controls (AMC) either received subdermal inoculation with complete Freund's adjuvant (CFA, n = 10) or did not receive any injections (n = 10) during the experiment.

Mice that had been exposed to EAE were split into two groups and performed intraocular injections in the 10 M.

In one group, 1 μl of scAAV-NDI1 triple capsid mutant was intravitreally injected

The other group received 1 μl of scAAVmCherry

As extra injection controls, 1 μl of scAAV-mCherry was injected into CFA mice.

Timeline:

• First treatment of control groups took place in 0 M to see if other factors may have potentially had an effect on the decrease in PERG and confirm the effect of the treatment in the experimental group.

• PERG/SD-OCT was performed between 1 M and 9 M to measure if there were changes in normal visual function

• Second treatment of control groups took place in 10 M to see if the injection of NDI1 can improve visual function in EAE mice and the PERG and SD-OCT were used to test the effect in 12 M

• Mice were euthanized 2 months post-AAV injections to perform other relevant tests and analysis.

# data[].attributes.attachment_caption
Multiple sclerosis (MS) is a chronic, autoimmune, inflammatory disease of the central nervous system (CNS)

# data[].attributes.body
https://www.news-medical.net/health/Types-of-Multiple-Sclerosis-%28MS%29.aspx