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Bioinformatics: EPIC arrays (UP)
NextSeq550: WGS of C-albicans clinical strains (VARCAL)
Next: RNAseq of C.albicans clinical strains (FunResist)

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26th June 2023 - 10h

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HotTopics (SPG), 7th July, 15h
Moderator: Prof. Manuel Santos

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Dia da Medicina Genómica - 2th June 2023
Next friday, at the anf of the FMUC.

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Tuesday, 30th May
After 16h we will have a visit of A3ES evaluators for the Integrated Master degree of Medicine (DCM).

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The iBiMED Symposium happened last friday!

https://simposioibimed.wixsite.com/home

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MAY 25-26, 2023

It is with my greatest pleasure that I welcome back the Post-graduate Symposium in Biomedicine to iBiMED. This symposium is a very important event of iBiMED's research program, concealing team building activities, open discussions, and the latest technical research advancements. This year, the symposium is organized by our newly established PhD commission to strengthen a new vision of iBiMED centered on people. The symposium will be a forum for ideas and will provide multiple opportunities to improve our research culture, to correct aspects of our working habits and to learn important strategies of career development.

iBiMED's research program has been consolidated over the past years. The quality of our research is gradually increasing and making important contributions to the national and international recognition of our university's Health Sciences Program. Additionally, we are at the forefront of sustainable research equally supporting the societal relevance of biomedical investigation. Being part of the new Academic Clinical Centre, a virtuous partnership with our associated members, namely the Aveiro (CHBV), Sta Maria da Feira (CHEDV), Gaia/Espinho (CHVNG/E) hospitals and several Health Centres of the Aveiro and Aveiro-Northern regions, will allow us to endeavour better working conditions, biomedical research infrastructures and the implementation of new programs on clinical and translational research, thriving new job opportunities to young researchers.

As the newly appointed coordinator of iBiMED, I'm enthusiastic and deeply grateful to be part of this team. I recognize the organizing committee of the 2023 Post-graduate Symposium for their hard work in preparing this important gathering, which will be of major importance for the FCT institutional evaluation taking place in late 2023. A special thank you to everyone involved and to the participants and wishes of a successful and productive post-graduate symposium. Finally, "the best way to predict the future is to create it", let's together, design a brilliant future for iBiMED.

Bruno Bernardes de Jesus

Coordinator of iBiMED

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MAY 25-26, 2023 It is with my greatest pleasure that I welcome back the Post-graduate Symposium in Biomedicine to iBiMED. This symposium is a very important event of iBiMED's research program, concealing team building activities, open discussions, and the latest technical research advancements.

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What is the link between genetic variants and disease?

Can genetic variability explain disease heterogeneity?

How can genomes be used to personalize Medicine?

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Francisco, S., Martinho, V., Ferreira, M., Reis, A., Moura, G., Soares, A.R. and Santos, M.A.S. 2022. The role of miRNAs on proteostasis decline and protein aggregation during brain and skeletal muscle aging. International Journal of Molecular Sciences. 23(6), 3232.

DOI: 10.3390/ijms23063232

http://hdl.handle.net/10773/34660

Marçalo, R., Neto, S., Pinheiro, M., Rodrigues, A.J., Sousa, N., Santos, M.A.S., Simão, P., Valente, C., Andrade, L., Marques, A. and Moura, G.R. 2022. Evaluation of the genetic risk for COVID-19 outcomes in COPD and differences among worldwide populations. PLoS One. 17(2).e0264009.

DOI: 10.1371/journal.pone.0264009

http://hdl.handle.net/10773/33905

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Barbosa, P., Melnyk, S., Bennuri, S.C., Delhey, L., Reis, A., Moura, G.R., Borsheim, E., Rose, S. and Carvalho, E. 2021. Redox imbalance and methylation disturbances in early childhood obesity. Oxidative Medicine and Cellular Longevity, ID 2207125.

DOI: 10.1155/2021/2207125.

http://hdl.handle.net/10773/34659

Ferreira, M., Francisco, S., Soares, A.R., Nobre, A., Pinheiro, M., Reis, A., Neto, S., Rodrigues, A.J., Sousa, N., Moura, G., Santos, M.A.S. 2021. Integration of segmented regression analysis with weighted gene correlation network analysis identifies genes whose expression is remodeled throughout physiological aging in mouse tissues. Aging, 13 (14), 18150-18190.

DOI: 10.18632/aging.203379.

Direito, I., Monteiro, L., Melo, T., Figueira, D., Lobo, J., Enes, V., Moura, G., Henrique, R., Santos, M.A.S., Jerónimo, C., Amado, F., Fardilha, M., Helguero, L.A. 2021. Protein aggregation patterns inform about breast cancer response to antiestrogens and reveal the RNA ligase RTCB as mediator of acquired tamoxifen resistance. Cancers. 13, 3196.

DOI: doi.org/10.3390/cancers13133195.

Bezerra, A.R., Oliveira, C., Correia, I., Guimarães, A.R., Sousa, G., Carvalho, M.J., Moura, G., Santos, M.A.S. 2021. The role of non-standard translation in Candida albicans pathogenesis. FEMS Yeast Res. 21(4), foab032.

DOI: 10.1093/femsyr/foab032

http://hdl.handle.net/10773/34661

Tavares, J.F., Davis, N.K., Poim, A., Reis, A., Kellner, S., Sousa, I., Soares, A.R., Moura, G.R., Dedon, P.C. and Santos, M. 2021. tRNA-modifying enzyme mutations induce codon-specific mistranslation and protein aggregation in yeast. RNA Biology, 18(4), 1-13.

DOI: 10.1080/15476286.2020.1819671.

http://hdl.handle.net/10773/30815

Guimarães, A.R., Correira, I., Sousa, I., Oliveira, C., Moura, M., Bezerra, A.R., Santos, M.A.S. 2021. tRNA as a driving force of genome evolution in yeast. Frontiers in Microbiology, ID: 634004.

DOI: doi.org/10.3389/fmicb.2021.634004.

http://hdl.handle.net/10773/34657

Castanho, T.C., Santos, N.C., Meleiro-Neves, C., Neto, S., Moura, G.R., Santos, M.A.S., Cruz, A.R., Cunha, O., Rodrigues, A.C., Rodrigues, A.J. and Sousa, N. 2021. Association of positive and negative life events with cognitive performance and psychological status in late life: a cross-sectional study in Northern Portugal. Aging Brain. 1, 100020.

DOI: 10.1016/j.nbas.2021.100020.

http://hdl.handle.net/10773/34658

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Finding genetic determinants of fungal adaptation to humans (2023/2024)

Gabriela Moura/Miguel Pinheiro Bolsa de estudo associada

MBIC genoma, MBMM

Candida albicans é um fungo normalmente comensal para os seres humanos, vivendo sem causar doença nas mucosas, pele e intestino humanos. A sua grande plasticidade genómica permite uma rápida adaptação a cada um destes nichos, que são por seu lado bastante diferentes, pelo que será de esperar que existam variantes genéticos associáveis a cada um deles. Neste projeto serão utilizadas ferramentas bioinformáticas para realizar estudos de associação à escala do genoma (GWAS) usando C. albicans como objeto de estudo, com o objetivo principal de compreender melhor como é conseguida essa adaptação.

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Exploring codon usage patterns in human transcriptomic datasets (2023/2024)

Gabriela Moura/Miguel Pinheiro

MBIC genoma, MBMM

Se é sabido que o conjunto de genes expressos pelas células/tecidos a cada momento pode variar substancialmente, já o risco desta flutuação originar insuficiências ao nível da maquinaria de tradução não está ainda totalmente esclarecido. Neste projeto, iremos utilizar ferramentas bioinformáticas desenvolvidas in house para explorar esta hipótese, avaliando as flutuações na utilização dos diferentes codões de transcriptomas humanos relativos a patologias, por forma a detetar distorções na forma como os codões são traduzidos que possam induzir instabilidade na fidelidade da síntese proteica.

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First insight on the Portuguese exome (2023/2024)

Gabriela Moura/Vasco Neves

MBIC genoma, MBMM

Com a progressiva descida dos custos de sequenciação de DNA e com o crescente conhecimento da importância do risco genético para a boa gestão de qualquer patologia (prevenção, estratificação de risco, severidade e/ou progressão, resposta ao tratamento, priorização e existência de implicações familiares), todos os países estão a elaborar estratégias para implementar a sequenciação de genomas e para majorar os seus benefícios, tanto para o indivíduo como para a comunidade. Neste contexto, o Laboratório de Medicina do Genoma está a implementar os protocolos de sequenciação de exomas completos (WES), tanto na vertente de wet-lab como na bioinformática. Com este projeto, pretende-se contribuir para este esforço, pela automatização de um pipeline para análise de dados raw de WES e extração de variantes, que possam ser utilizados depois em contexto investigacional.

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Unveiling inter-kingdom interactions within the human microbiome (2023/2024)

Gabriela Moura/Vasco Neves

MBIC genoma, MBMM

A relevância do microbioma para a manutenção da saúde dos seres humanos é já um dado adquirido nos dias de hoje. No entanto, sobretudo por limitações metodológicas, o conhecimento de todas as dimensões envolvidas nesta comunidade extremamente complexa é ainda muito limitado. Com a descida continuada dos custos de sequenciação do DNA, a tecnologia de shotgun metagenomics apresenta-se como a forma privilegiada de fornecer ao investigador a composição total do microbioma de cada indivíduo, e não apenas a sua comunidade bacteriana, fúngica, viral ou parasítica. Este projeto visa implementar as fundações metodológicas da metagenómica por sequenciaão total do DNA, como primeiro passo para identificar flutuações no microbioma total do intestino humano que possam informar sobre o seu estado de saúde.

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We are located at rooms 30A.3.29 to 30A.3.31 of the Health Sciences building of the University of Aveiro (Crasto Campus).

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The lab is equipped with two microarray platforms, Illumina and Nanopore DNA sequencers and NGS support equipment, computation and software.
Ongoing genome sequencing and analysis focus on comparative and evolutionary genomics of yeast, mouse, human cells and tissues, with particular emphasis on detection of single nucleotide polymorphisms (SNPs), copy number variants (CNVs), indels, loss of heterozigozity (LOH) and aneuploidies. Bioinformatics pipelines for analysis of RNASeq, methylomics and whole genome genotyping data are permanently being run and updated, at a dedicated computational cluster (STiC_UA) that also integrates the Genome Medicine Lab.

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Goals:
PI: Gabriela Moura
Link: https://www.ua.pt/en/projetos-id/1233

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ONGOING: Building Capacity in the Centre Region for Precision Medicine

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ONGOING: Building Capacity in the Centre Region for Precision Medicine

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Goals:
PI at UA: Gabriela Moura
Link: https://www.ua.pt/pt/projetos-id/1016

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Goals:
PI: Gabriela Moura
Link: https://www.ua.pt/pt/projetos-id/1068

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Francisco, S., Ferreira, M., Moura, G., Soares, A.R. and Santos, M.A.S. 2020. Does proteostasis get lost in translation ? Implications for protein aggregation across the lifespan. Ageing Research Reviews 62 : 101119.

DOI : 10.1016/j.arr.2020.101119.

http://hdl.handle.net/10773/28883

Vitorino, R., Guedes, S., Trindade, F., Correira, I., Moura, G., Carvalho, P., Santos, M.A.S. and Amado, F. 2020. De novo sequencing of proteins by mass spectrometry. Expert Review of Proteomics. 17, 595-607.

DOI: 10.1080/14789450.2020.1831387.

http://hdl.handle.net/10773/30814

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Cela, M., Paulus, C., Santos, M.A.S., Moura, G.R., Frugier, M., Rudinger-Thirion, J. 2018. Plasmodium apicoplast tyrosyl-tRNA synthetase recognizes an anusual, simplified set in cognate tRNATyr. PLoS One 13(12):e0209805.

DOI: 10.1371/journal.pone.0209805.

http://hdl.handle.net/10773/27628

Melro, H., Gomes, J., Moura, G., Marques, A. 2018. Genetic profile and patient-reported outcomes in chronic obstructive pulmonary disease: a systematic review. PLoS One 13(6):e0198920.

DOI: 10.1371/journal.pone.0198920.

http://hdl.handle.net/10773/23641

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Weil T, Santamaría R, Lee W, Rung J, Tocci N, Abbey D, Bezerra AR, Carreto L, Moura GR, Bayés M, Gut IG, Csikasz-Nagy A, Cavalieri D, Berman J, Santos MAS. 2017. Adaptive mistranslation accelerates the evolution of fluconazole resistance and induces major genomic and gene expression alterations in Candida albicans. mSphere 2:e00167-17.

DOI: 10.1128/mSphere.00167-17.

http://hdl.handle.net/10773/27629

Bódi, Z., Farkas, Z., Nevozhay, D., Kalapis, D., Lázár, V., Csörgõ, B., Nyerges, A., Szamecz, B., Fekete, G., Papp, B., Araújo, H., Oliveira, J.L., Moura, G., Santos, M.A.S., Székely, T., Balázsi, G., Pál, C. 2017. Phenotypic heterogeneity promotes adaptive evolution. PLoS Biology, 15(5), e2000644.

DOI: 10.1371/journal.pbio.2000644.

http://hdl.handle.net/10773/27800

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Simões, J., Bezerra, A.R., Moura, G.R., Araújo, H., Gut, I., Bayes, M., Santos, M.A.S. 2016. The fungus Candida albicans tolerates ambiguity at multiple codons. Frontiers in Microbiology, 7, 1.

DOI: 10.3389/fmicb.2016.00401.

http://hdl.handle.net/10773/27803

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Soares, A.R., Fernandes, N., Reverendo, M., Araújo, H.R., Oliveira, J.L., Moura, G.R., Santos, M.A.S. 2015. Conserved and highly expressed tRNA derived fragments in zebrafish. BMC Mol. Biol. 16 (1),22.

DOI: 10.1186/s12867-015-0050-8.

http://hdl.handle.net/10773/27821

Ragionieri, L., Vitorino, R., Frommlet, J., Oliveira, J.L., Gaspar, P., Pouplana, L.R., Santos, M.A.S., Moura, G.R. 2015. Improving the accuracy of recombinant protein production through integration of bioinformatics, statistical and mass spectrometry methodologies. FEBS Journal. 282 (4),769-787.

DOI: 10.1111/febs.13181.

http://hdl.handle.net/10773/27839

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Reverendo, M., Soares, A.R., Pereira, P.M., Carreto, L., Ferreira, V., Gatti, E., Pierre, P., Moura, G.R., Santos, M.A.S. 2014. tRNA mutations that affect decoding fidelity deregulate development and proteostasis network in zebrafish. RNA Biology. 11 (8), 1199-1213.

DOI: 10.4161/rna.32199.

http://hdl.handle.net/10773/27840

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Bezerra, A.R., Simões, J., Lee, W., Rung, J., Weil, T., Gut, I.G., Gut, M., Bayés, M., Rizzetto, L., Cavalieri, D., Giovannini, G., Bozza, S., Romani, L., Kapushesky, M., Moura, G. R. and Santos, M.A.S. 2013. Reversion of a fungal genetic code alteration links proteome instability with genomic and phenotypic diversification. Proceedings of the National Academy of Sciences. 110 (27), 11079-11084.

DOI: 10.1073/pnas.1302094110.

http://hdl.handle.net/10773/24428

Mateus, D.D., Paredes, J.A., Español, Y., de Pouplana, L.R., Moura, G. R. and Santos, M.A.S. 2013. Molecular reconstruction of a fungal genetic code alteration. RNA Biology. 10 (6), 969-981.

DOI: 10.4161/rna.24683.

http://hdl.handle.net/10773/24276

Gaspar, P., Moura, G., Santos, M.A.S. and Oliveira, J.L. 2013. mRNA secondary structure optimization using a correlated stem-loop prediction. Nucleic Acids Research. 41 (6), e73.

DOI: 10.1093/nar/gks1473.

http://hdl.handle.net/10773/24283

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Gaspar, P., Oliveira, J.L., Frommlet, J., Santos, M.A.S. and Moura, G. 2012. EuGene: maximizing synthetic gene design for heterologous expression. Bioinformatics. 28 (20), 2683-2684.

DOI: 10.1093/bioinformatics/bts465.

http://hdl.handle.net/10773/26717

Soares, A.R., Reverendo, M., Pereira, P.M., Nivelles, O., Pendeville, H., Bezerra, A.R., Moura, G.R., Struman, I. and Santos, M.A.S. 2012. Dre-miR-2188 targets Nrp2a and mediates proper intersegmental vessel development in zebrafish embryos. PLoS ONE. 7 (6), e39417.

DOI: 10.1371/journal.pone.0039417.

http://hdl.handle.net/10773/26659

Paredes, J.A., Carreto, L., Simões, J., Bezerra, A,R, Gomes, A.C., Santamaria, R., Kapushesky, M., Moura, G.R. and Santos, M.A.S. 2012. Low level mistranslations deregulate the transcriptome and translatome and generate proteotoxic stress in yeast. BMC Biology. 10 (1), 55.

DOI: 10.1186/1741-7007-10-55.

http://hdl.handle.net/10773/26946

Soares, A.R., Pereira, P.M., Ferreira, V., Reverendo, M., Simões, J., Bezerra, A.R., Moura, G.R. and Santos, M.S. 2012. Ethanol exposure induces up-regulation of specific microRNAs in zebrafish embryos. Toxicological Sciences. 127 (1), 18-28.

DOI: 10.1093/toxsci/kfs068.

http://hdl.handle.net/10773/26712

Lousado, J.P., Oliveira, J.L., Moura, G.R., and Santos, M.A.S. 2012. An integrative approach for orthologous genes comparison. International Journal of Data Mining and Bioinformatics. 6 (4), 369-381.

DOI: 10.1504/IJDMB.2012.049294

http://hdl.handle.net/10773/27635

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Moura, G.R., Pinheiro, M., Freitas, A., Oliveira, J.L., Frommlet, J.C., Carreto, L., Soares, A.R., Bezerra, A.R. and Santos, M.A.S. 2011. Species-specific codon context rules unveil non-neutrality effects of synonymous mutations. PLoS One. 6 (10), e26817.

DOI: 10.1371/journal.pone.0026817

http://hdl.handle.net/10773/27639

Santos, M.A.S., Gomes, A.C., Santos, M.C., Carreto, L. and Moura, G.R. 2011. The genetic code of the fungal CTG clade. Comptes Rendus Biologies. 334, 8-9.

DOI: 10.1016/j.crvi.2011.05.008

http://hdl.handle.net/10773/27643

Carreto, L., Eiriz, M.F., Domingues, I., Schuller D., Moura, G.R. and Santos, M.A.S. 2011. Expression variability of co-regulated genes differentiates Saccharomyces cerevisiae strains. BMC Genomics, 12, 201.

DOI: 10.1186/1471-2164-12-201.

http://hdl.handle.net/10773/25318

Freitas, A., Afreixo, V., Pinheiro, M., Oliveira, J.L., Moura, G.R. and Santos, M. 2011. Improving the performance of the iterative signature algorithm for the identification of relevant patterns. Statistical Analysis and Data Mining. 4 (1), 71-83.

DOI: 10.1002/sam.10104.

http://hdl.handle.net/10773/6913

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Moura, G.R., Paredes, J.A. and Santos, M.A.S. 2010. Development of the genetic code: insights from a fungal codon reassignment. FEBS Letters. 584, 334-341.

DOI: 10.1016/j.febslet.2009.11.066

http://hdl.handle.net/10773/27657

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Moura, G.R., Carreto, L.C. and Santos, M.A.S. 2009. Genetic code ambiguity: an unexpected source of proteome innovation and phenotypic diversity. Current Opinion in Microbiology. 12, 1-7.

DOI: 10.1016/j.mib.2009.09.004

http://hdl.handle.net/10773/27660

Soares, A.R., Pereira, P.M., Santos, B., Egas, C., Arrais, J., Moura, G.R. and Santos, M.A.S. 2009. Parallel DNA pyrosequencing unveils new zebrafish microRNAs. BMC Genomics. 10, 195.

DOI: 10.1186/1471-2164-10-195

http://hdl.handle.net/10773/27658

Silva, R.M., Duarte, I.C.N., Paredes, J.A., Lima-Costa, T., Perrot, M., Boucherie, H., Goodfellow, B.J., Gomes, A.C., Mateus, D.D., Moura, G.R. and Santos, M.A.S. 2009. The yeast PNC1 longevity gene is up-regulated by mRNA mistranslation. PLoS One. 4, e5212.

DOI: 10.1371/journal.pone.0005212

http://hdl.handle.net/10773/27659

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Moura, G., Lousado, J.P., Pinheiro, M., Carreto, L., Silva, R.M., Oliveira, J.L. and Santos, M.A.S. 2007. Codon-triplet context unveils unique features of the Candida albicans protein coding genome. BMC Genomics. 8, 444.

DOI: 10.1186/1471-2164-8-444

http://hdl.handle.net/10773/27671

Silva, R.M., Paredes, J.A., Moura, G., Manadas, B., Lima-Costa, T., Rocha, R., Miranda, I., Gomes, A.C., Koerkamp, M.J.G., Perrot, M., Holstege, F.C.P., Boucherie, H. and Santos, M.A.S. 2007. Critical roles for a genetic code alteration in the evolution of the genus Candida. EMBO Journal. 26, 4555-4565.

DOI: 10.1038/sj.emboj.7601876

http://hdl.handle.net/10773/27669

Miranda, I., Rocha, R., Santos, M.C., Mateus, D.D., Moura, G., Carreto, L. and Santos, M.A.S. 2007. A genetic code alteration is a phenotype diversity generator in the human pathogen Candida albicans. PLoS One. 2, e996.

DOI: 10.1371/journal.pone.0000996

http://hdl.handle.net/10773/27675

Moura, G., Pinheiro, M., Arrais, J., Gomes, A.C., Carreto, L., Freitas, A., Oliveira, J.L. and Santos, M.A.S. 2007. Large scale comparative codon-pair context analysis unveils general rules that fine tune evolution of mRNA primary structure. PLoS One. 2, e847.

DOI: 10.1371/journal.pone.0000847

http://hdl.handle.net/10773/27684

Gomes, A.C., Miranda, I., Silva, R.M., Moura, G., Thomas, B., Akoulitchev, A. and Santos, M.A.S. 2007. A genetic code alteration generates a proteome of high diversity in the human pathogen Candida albicans. Genome Biology. 8, R206.

DOI: 10.1186/gb-2007-8-10-r206

http://hdl.handle.net/10773/27664

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Pinheiro, M., Afreixo, V., Moura, G., Freitas, A., Santos, M.A.S. and Oliveira, J.L. 2006. Statistical, computational and visualization methodologies to unveil gene primary structure features. Methods of Information in Medicine. 45, 163-168.

DOI: 10.1267/METH06020163

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Moura, G., Pinheiro, M., Silva, R., Miranda, I., Afreixo, V., Dias, G., Freitas, A., Oliveira, J.L. and Santos, M.A.S. 2005. Comparative context analysis of codon pairs on an ORFeome scale. Genome Biology. 6: R28(1-14).

DOI: 10.1186/gb-2005-6-3-r28

http://hdl.handle.net/10773/27689

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Santos, M.A.S., Moura, G., Massey, S. and Tuite, M.F. 2004. Driving change: the evolution of alternative genetic codes. Trends in Genetics. 20, 95-102.

DOI: 10.1016/j.tig.2003.12.009

http://hdl.handle.net/10773/27691

Silva, R., Miranda, I., Moura, G. and Santos, M. A. S. 2004. Yeast as a model organism for studying the evolution of non-standard genetic codes. Briefings in Functional Genomics & Proteomics. 3, 35-46.

DOI: 10.1093/bfgp/3.1.35

http://hdl.handle.net/10773/27692

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Massey, S.E., Moura, G., Beltrão, P., Almeida, R., Garey, J.R., Tuite, M.F. and Santos, M.A.S. 2003. Comparative evolutionary genomics unveils the molecular mechanism of reassignment of the CTG codon in Candida spp. Genome Research. 13, 544-557.

DOI: 10.1101/gr.811003

http://hdl.handle.net/10773/27694

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Moura, G., Miranda, I., Cheesman, C., Tuite, M.F. and Santos, M.A.S. 2002. Stop codon decoding in Candida albicans: from non-standard back to standard. Yeast, 19, 727-733.

DOI: 10.1002/yea.874

http://hdl.handle.net/10773/27699

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2012 - Francelos

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iBiMED retreat - Vista Alegre

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Goals:
PI: Gabriela Moura
Link:

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Goals:
PI: Gabriela Moura
Link:

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Finished: Developing new tools for studying mRNA mistranslation

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Finished: Developing new tools for studying mRNA mistranslation

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Goals:
PI: Gabriela Moura
Link:

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Over the past five years, the Genome Medicine facility has become an integral part of every visit to the Department of Medical Sciences. Over 400 individuals, ranging from high-school and university students to researchers and government officials, have sought out the opportunity to visit this state-of-the-art research infrastructure.

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Additionally, the Genome Medicine facility demonstrated its commitment to public health by voluntarily conducting COVID-19 RT-PCR testing for hospitals and the social security ministry during the height of the pandemic. Impressively, they successfully carried out over 38,000 tests, including several hundred tests for University of Aveiro ERASMUS students, ensuring their safe return to in-person classes.

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Since 2016, GM provided scientific activities to >60 high-school students from the Aveiro region, under the scope of Academia de Verão.

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Universidade de Aveiro debate bioinformática até 17 de Abril

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‘No fundo, é algo muito simples e que pode ser resumido como o uso dos computadores e do ‘software’ para a resolução dos múltiplos problemas da biologia’, afirma a investigadora Gabriela Moura. E justifica: ’Os assuntos da biologia disponibilizam gr