# data[].attributes.headline
Use of SSRI in first trimester may increase risk of cardiovascular or other congenital malformation

# data[].attributes.subject
Use of SSRI in first trimester may increase risk of cardiovascular or other congenital malformation

# data[].attributes.headline
Neonates exposed to SSRI in third trimester have respiratory distress, cyanosis, apnea, seizure, temperature instabilitiy, feeding difficulty, vomitting, irritability and constant crying

# data[].attributes.subject
Neonates exposed to SSRI in third trimester have respiratory distress, cyanosis, apnea, seizure, temperature instabilitiy, feeding difficulty, vomitting, irritability and constant crying

# data[].attributes.headline
Newborns should be monitored if the maternal use of this drug continue during pregnancy especially third trimester

# data[].attributes.subject
Newborns should be monitored if the maternal use of this drug continue during pregnancy especially third trimester

# data[].attributes.headline
Setraline may cause withdrawal reaction in neonates

# data[].attributes.subject
Setraline may cause withdrawal reaction in neonates

# data[].attributes.body
Amitriptyline

# data[].attributes.body
According to cumulative data, the use of this drug is safer since it is lack of fetotoxicity when use within the dose recommendation.

# data[].attributes.body
Dose: PO 50-75mg per day, may increase gradually to 150mg/day. MAX 300mg/day

# data[].attributes.body
Since the patient is 42 years old (high risk group), there is an increased risk of miscarriage and foetal malformation Sertraline should be tapered down slowly and stopped eventually.

# data[].attributes.body
Switch sertraline to amitriptyline 50mg/day.

# data[].attributes.body
While taking the medicine, monitor her depression condition and check whether the medicine is well tolerated.

# data[].attributes.body
However, the dose of amitriptyline should be tapered three to four weeks before the expected date of delivery to minimise the withdrawal symptoms by the newborn baby such as jitteriness, hyperexcitability, myoclonus and convulsion.