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Women are twice as likely as men to suffer from MDD.

While it can occur at any age, the average age at onset is the mid-20s.

Despite more women suffering from depression, a man is more likely to die from suicide -- however, women attempt suicide more frequently than men do.

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"My Major Depression Story" by Bernice Anderson

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"My Major Depression Story" by Bernice Anderson

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Bernice suffered with MDD for a long time before a suicide attempt finally steered her in the direction of getting treatment. She addresses misconceptions like the idea that medication alone can solve all the person's problems, or that simply trying hard enough to be happy isn't effective. She explains that it required a combination of medication and therapy in order for her to manage her depression, and that even now, after many years of suffering from it, it has not been "cured." She says it's very important to stick with treatments, however, in order to continue to maintain a "normal" lifestyle.

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My Major Depression Story | HealthyPlace

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Here's my story of living with major depression, managing symptoms with antidepressants and family support.

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Major Depressive Disorder has many different causes that can come from various places and occur at any time in life, though the most prevalent cause of the disorder is genetics. The risk of suffering from MDD triples if you have a close relative -- a parent, sibling, or child -- that suffers from MDD.

The symptoms of the disorder, in addition to contributing to or worsening pre-existing depression, can also cause the disorder, including things like overeating or deregulating your sleep schedule.

Physiological factors are thought to contribute to MDD as well, though it's unknown to what extent. Changes in socioeconomic stability, such as a loss of a job, or a divorce, can also lead to a patient developing Major Depressive. For children and young adults, abuse from their parents or a romantic partner, being kicked out of their house or running away, and bullying can lead to the development of MDD.

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The symptoms MUST cause clinically significant distress or impairment in social, occupational, or other important areas of functioning, and the episode can't be attributable to the physiological affects of a substance or to another medical condition.

The occurrence of Major Depressive cannot be able to be better explained by schizoaffective disorder, schizophrenia, schizophreniform disorder, delusional disorder, or any other specified or unspecified schizophrenia spectrum or other psychotic disorders.

There has never been a manic or hypomanic episode (this would instead be bipolar depression; MDD is considered unipolar depression.)

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Typically, symptoms manifest themselves as coping mechanism (generally unhealthy ones) and reactions to how the patient feels.

Symptoms include persistent negative thinking with an inability to see positive solutions, agitation, restlessness, inability to focus, lashing out at loved ones, irritability, withdrawing from loved ones and regular activities, increase in sleeping, exhaustion/lethargy, morbid suicidal thoughts, and weight loss or gain.

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Five or more of the following symptoms for a period of two weeks or longer, that cannot clearly be attributed to a medical cause and represent a change in normal functioning.

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Nico Minoru is a main character in Marvel's TV and comic series Runaways. She exhibits signs early on of suffering from MDD that likely began shortly after her sister was found dead by apparent suicide in her room one morning. She experiences a dramatic appearance change, going from relatively normal to dressing in an extreme goth fashion (which can be observed in the clip linked.) We also see a tarnished relationship with her family and her old friend group. She prefers to be alone and spends most of her time listening to music by herself. She also often goes into her sister's old room just to spend time in there, and clearly misses her. Because her sister dies two years prior to the show's plot, these symptoms have persisted long enough to meet the criteria of a diagnosis. She is almost always in a bad mood early on in the show and usually sees the negative in situations rather than the positive. She blames herself for her sister's death even though it had nothing to do with her, and she feels immense guilt for it. She is especially irritable to her parents and former friends.

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Marvel’s Runaways: 1×1 - Introducing Nico Minoru!!

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The most effective treatment for Major Depressive is generally a combination of psychotherapy and taking antidepressants. While electroconvulsive therapy is also a valid treatment, it is avoided as much as possible and only used in extreme cases.

A psychiatrist can perform both psychotherapy and medical services, however some patients choose to see a psychiatrist for the medical aspect only and talk to a psychologist for their psychotherapy.

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https://www.psycom.net/depression.central.major.html

https://images.pearsonclinical.com/images/assets/basc-3/basc3resources/DSM5_DiagnosticCriteria_MajorDepressiveDisorder.pdf

https://www.hopkinsmedicine.org/healthlibrary/conditions/mental_health_disorders/mental_health_disorder_statistics_85,P00753