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Why does replication start at specific locations on DNA?

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I learned that Helicase opens up the DNA at the replication fork.

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I learned that DNA replication is semiconservative, which means that each strand in the DNA double helix acts as a template for the synthesis of a new strand.

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I learned that replication starts at specific locations on the DNA, which are called origins of replication.

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What I learned is how DNA replication is semi conservative. Each strand in the double helix acts as a template for synthesis of a new, complementary strand.

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I learn that I suck at bio

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I learned that DNA polymerases can only add nucleotides to the 3' end of an existing DNA strand.

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DNA replication requires other enzymes in addition to DNA polymerase, including DNA primase, DNA helicase, DNA ligase, and topoisomerase.

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I learned that cells need to copy their DNA quickly and with a few errors or risk problems such as cancer. To prevent the errors they use a variety of enzymes and proteins, which work together to make sure the DNA replication is smoothly and accurately.

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Helicase’s job is to unwind the DNA.

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Helicase's job is to move the replication forks forward by "unwinding" the DNA (breaking the hydrogen bonds between the nitrogenous base pairs).

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DNA replication is semiconservative. Each strand in the double helix acts as a template for synthesis of a new, complementary strand.

New DNA is made by enzymes called DNA polymerases, which require a template and a primer (starter) and synthesize DNA in the 5' to 3' direction.

During DNA replication, one new strand (the leading strand) is made as a continuous piece. The other (the lagging strand) is made in small pieces.

DNA replication requires other enzymes in addition to DNA polymerase, including DNA primase, DNA helical, DNA ligase, and topoisomerase.

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I learned that There are about 3 billion base pairs of DNA in our  genome which must be accurately copied when any one of your trillions of cells divides.

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DNA polymerase is responsible for synthesizing DNA.

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DNA polymerase is responsible for synthesizing DNA.

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During the process of replication, the DNA double helix opens so each strand can be copied and made into a new strand. This process creates two similar double helices that contain one new strand of DNA and an old one.

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Alexander

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One new strand, which runs 5' to 3' towards the replication fork, is the easy one. This strand is made continuously, because the DNA polymerase is moving in the same direction as the replication fork. This continuously synthesized strand is called the leading strand.

The other new strand, which runs 5' to 3' away from the fork, is trickier. This strand is made in fragments because, as the fork moves forward, the DNA polymerase (which is moving away from the fork) must come off and reattach on the newly exposed DNA. This tricky strand, which is made in fragments, is called the lagging strand.

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"Proteins called single-strand binding proteins coat the separated strands of DNA near the replication fork, keeping them from coming back together into a double helix."

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"Proteins called single-strand binding proteins coat the separated strands of DNA near the replication fork, keeping them from coming back together into a double helix."

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Helicase opens up the DNA at the replication fork.
Single-strand binding proteins coat the DNA around the replication fork to prevent rewinding of the DNA.
Topoisomerase works at the region ahead of the replication fork to prevent supercoiling.
Primase synthesizes RNA primers complementary to the DNA strand.
DNA polymerase III extends the primers, adding on to the 3' end, to make the bulk of the new DNA.
RNA primers are removed and replaced with DNA by DNA polymerase I.
The gaps between DNA fragments are sealed by DNA ligase.

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so dna can become this replication bubble