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Article for a possible cure to Cystic Fibrosis

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Article for a possible cure to Cystic Fibrosis

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https://www.medicalnewstoday.com/articles/316837.php
In CF, the mutation - called "p.Phe508del" - makes the CFTR protein degrade prematurely, which causes poor chloride permeability and can lead to lung inflammation. A recent study found that the drug Tα1, also known as Zaxadin, has the capability to treat and halt infection of CF. Its beneficial action is twofold: the drug was able to simultaneously reduce the inflammation typical of CF and improve the activity, maturation, and stability of CFTR.

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https://www.chop.edu/stories/cystic-fibrosis-angela-s-story

Angela has been battling Cystic Fibrosis since she was only 3 months old. However, that never stopped her from doing what she loves; dancing. Angela underwent the chest wall oscillation procedure, and it's helped her perform her best everyday ever since. Angela had a very successful dance career and is now a dance teacher for children.

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Cystic Fibrosis (CF) is a hereditary disease that causes the buildup of mucus and sweat in certain organs, mainly in the lungs and pancreas. It causes normally thin and slippery mucus to become thick and sticky. This causes complications in the lungs as it can lead to breathing problems and lung infections.

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In order to inherit this disease, you must have two dominant alleles from the parents in the phenotype, otherwise, you are either a carrier or are normal. This condition is due to a mutation in the CFTR gene that is in charge of regulating the chloride transport channel across the cell membrane. Chlorine helps to balance out the water and salt concentration in the cell, however this mutation results in a dehydration of the cell, causing a high salt concentration. This is what causes the bodily fluids that use this channel to become thick and sticky, such as the mucus, saliva, sweat, and tears. A malfunction in this gene can either cause a disruption in the normal production of the protein or have it not produce the CFTR protein at all.

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Treatments and cures for Cystic Fibrosis

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Treatments and cures for Cystic Fibrosis

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There is no permanent cure for Cystic Fibrosis as of right now. However there are treatments that could ease the symptoms temporarily.

The Pneumococcal vaccine can be taken as a preventative. This vaccine prevents certain bacterial lung infections.

Antibiotics and cough medicine can help ease the symptoms. Penicillin can be taken to stop the growth of the bacteria.

The medical procedure for chest wall oscillation uses a device to rhythmically press on chest and remove mucus from the lung.

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The thick and sticky mucus that is produced blocks the airways in the lungs, which is why lung infections are caused. As for the pancreas, this organ produces and secretes digestive enzymes into the small intestines. With Cystic Fibrosis, the passageways in the pancreas are clogged, blocking any enzymes to go to the intestines. This disrupts the digestive system from function properly.

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“Cystic Fibrosis.” Mayo Clinic, Mayo Foundation for Medical Education and Research, 9 July 2019, https://www.mayoclinic.org/diseases-conditions/cystic-fibrosis/symptoms-causes/syc-20353700.

“About Cystic Fibrosis.” CF Foundation, https://www.cff.org/What-is-CF/About-Cystic-Fibrosis/.

“Cystic Fibrosis | CF | Cystic Fibrosis Symptoms.” MedlinePlus, U.S. National Library of Medicine, 25 Apr. 2019, https://medlineplus.gov/cysticfibrosis.html.

Tidy, Colin. “Cystic Fibrosis: Symptoms, Causes and Treatment.” Patient.info, https://patient.info/chest-lungs/cystic-fibrosis-leaflet.

“CFTR Gene - Genetics Home Reference - NIH.” U.S. National Library of Medicine, National Institutes of Health, https://ghr.nlm.nih.gov/gene/CFTR.

“CF Genetics: The Basics.” CF Foundation, https://www.cff.org/What-is-CF/Genetics/CF-Genetics-The-Basics/.

Rimington Trophy Official Website: What Is Cystic Fibrosis, http://www.rimingtontrophy.com/boomer/what/.

Children's Hospital. “Cystic Fibrosis: Angela's Story.” Children's Hospital of Philadelphia, The Children's Hospital of Philadelphia, 6 Sept. 2016, https://www.chop.edu/stories/cystic-fibrosis-angela-s-story.

“Cystic Fibrosis (for Teens).” Edited by Floyd R. Livingston Jr., KidsHealth, The Nemours Foundation, Apr. 2014, https://kidshealth.org/en/teens/cystic-fibrosis.html.