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Family history of the disease

Autosomal dominant gene

only need one copy of the mutation to inherit it

Very rarely acquired

hyperthyroidism

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VWD is a blood disorder in which the blood lacks proteins that inhibit clotting when needed.

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Type 1

Most common and mildest form

Lower than normal Von Willebrand factor (VWF)

About 85% of people treated for VWD have Type 1

Type 2

Have normal VWF but the factor doesn't work correctly

Type 2A, VWF is not the proper size and doesn't help platelets attach together

Type 2B, VWF attaches to platelets when there is no injury and the body removes platelets with VWF, decreasing platelets and VWF when it's needed

Type 2M, VWF does not attach to platelets

Type 2N, VWF attaches to platelets but does not attach to Factor VIII, which is also needed to clotting

Type 3

Most severe form of VWD

Individual has little to no VWF and low factor VIII

3% of people with VWD have Type 3

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Frequent or Hard-to-Stop Nosebleeds

Occurs often (5 or more times a year)

Last more than 10 minutes

Occur spontaneously, without injury

Need packing or cautery

Easy Bruising

Occurs with no trauma or injury

Occurs often

Appearance: 2.5 cm or larger and raised

Heavy Menstrual Bleeding

Gushing of blood

Large clots

Soaking through a pad or tampon every 1-2 hours

Diagnosed with anemia

Longer than Normal Bleeding after Injury, Surgery, Childbirth, or Dental Work

Bleeding last more than 5 minutes after a cut to the skin

Heavy, prolonged bleeding after surgery or childbirth

Surgery site oozes blood longer than 3 hours after surgery

Blood in stool or urine

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Von Willebrand disease diagnosis and treatment article

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LAB DIAGNOSIS OF VON WILLEBRAND DISEASE - Histopathology.guru

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Please click here if you are not redirected within a few seconds. Images LAB DIAGNOSIS OF VON WILLEBRAND DISEASE - Histopathology.guru www.histopathology.guru Images may be subject to copyright.

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Centers for Disease Control and Prevention. (2021). What is von willebrand disease? Centers for Disease Control and Prevention. Retrieved May 30, 2022, from https://www.cdc.gov/ncbddd/vwd/facts.html

Roberts, J. C., & Flood, V. H. (2015). Laboratory diagnosis of von Willebrand disease. International journal of laboratory hematology, 37 Suppl 1(Suppl 1), 11–17. https://doi.org/10.1111/ijlh.12345

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Factor VIII clotting activity―To measure the amount of factor VIII in the blood

Von Willebrand factor antigen―Measures the amount of VWF in the blood

Ristocetin cofactor or other VWF activity―Measures how well the VWF works

Von Willebrand factor multimers―To measure the makeup or structure of the VWF

Platelet aggregation tests―Measures how well the platelets are working

(CDC, 2021)