# data[].attributes.body
Angelman Syndrome affects males and females at a very similar rate. The deletion in chromosome 15 occurs in about 1 in 12,000-20,000 births.

# data[].attributes.body
Most cases of Angleman Syndrome are not inherited. Angelman Syndrome is caused by a deletion in the maternal chromosome 15, whihc is why there is no known genetic inheritance. These genetic changes occur randomly during the formation of the sperm and egg cells.

# data[].attributes.body
Angelman Syndrome can sometimes be cause by a chromosomal rearrangement, called translocation, or by a defect in the region of DNA that controls the activation of the UBE3A gene. The UBE3A gene is associated with chromosome 15. Genetic changes like these can turn off UBE3A or other genes on the maternal copy of chromosome 15.

# data[].attributes.attachment_link.title
Our Daughter's RARE DIAGNOSIS - Angelman Syndrome

# data[].attributes.attachment_link.description
This youtube video is about our Daughter and her rare diagnosis of Angelman Syndrome. Angelman Syndrome is a rare genetic and neurological disorder caused by a genetic mutation of the gene UBE3A located on Chromosome 15 in the brain. It affects 1 in approximately every 12 - 20,000 births, and is sometimes misdiagnosed as Autism or Cerebral Palsy.

# data[].attributes.body
There are no known prevention methods or ways to control this disease.

# data[].attributes.body
-Seizures are common, usually beginning at age two.
-Stiff or jerky movements, along with small head size, and flatness in the back of the head.
-Tongue thrusting is usually seen in children with Angelman Syndrome.
-Unusual behaviors, such as hand flapping and arms uplifted while walking, and excessive laughter is common.

# data[].attributes.body
“Angelman Syndrome - Genetics Home Reference.” U.S. National Library of Medicine, National Institutes of Health, 20 Mar. 2018, ghr.nlm.nih.gov/condition/angelman-syndrome.

“Angelman Syndrome.” Mayo Clinic, Mayo Foundation for Medical Education and Research, 2 Mar. 2018, www.mayoclinic.org/diseases-conditions/angelman-syndrome/diagnosis-treatment/drc-20355627.

“Angelman Syndrome.” NORD (National Organization for Rare Disorders), 2018, rarediseases.org/rare-diseases/angelman-syndrome/.

“What Is AS?” Angelman Syndrome Foundation, www.angelman.org/what-is-as/.

“Angelman Syndrome | FAST.” FAST (Foundation for Angelman Syndrome Therapeutics), cureangelman.org/understanding-angelman.

# data[].attributes.body
Although there is no cure for Angelman Syndrome right now,  researchers are focusing on targeting specific genes for treatment. Current treatment focuses on managing the medical and developmental issues.These treatments include anti-seizure medication, physical therapy, communication therapy, and behavior therapy. All of these treatments are used mainly to control that side effects that come with the disease.

# data[].attributes.body
Children affected usually experience delayed development, intellectual disability, severe speech impairment, and problems with movement and balance.  Other common features include unusually fair skin and light colored hair.  Frequent laughter, smiling, and hand-flapping movements are also common.

# data[].attributes.body
Angelman Syndrome is a genetic disorder that primarily affects the nervous system.  Many of the characteristics of Angelman Syndrome are derived from the loss of function of the gene called "UBE3A".