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Genetics

Even if neither parents have hemophilia, a son can (see picture)

If mother has hemophilia, any sons will

Pictures show possible crosses

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Life Expectancy

Without proper treatment, many with Hemophilia die before they reach adulthood.

With proper treatment life expectancy is 10 years less than that of a normal person.

Prenatal Tests

It is not necessary to perform any prenatal tests for hemophilia unless of a termination of the pregnancy if the child has hemophilia.

The FVIII level should be checked about a month or so before delivery.

Once the child is born a cord blood sample is checked to see if the child has hemophilia.

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In the Population

Rare

Roughly 20,000 people in the U.S.

Hemophilia A

About 1 in 5,000-10,000 males

Hemophilia B

About 1 in 40,000-50,000 males

Extremely rare in females

Affects all races the same

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http://www.hog.org/handbook/section/2/how-hemophilia-is-inherited

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http://www.hog.org/handbook/section/2/how-hemophilia-is-inherited

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Signs and Symptoms

People with Hemophilia usually bleed longer

Bleeding can occur internally

In joints and muscles

Or externally

Minor cuts, dental procedures, or trauma

Severity depends on the amount of FVIII or FIX is in the plasma

In severe cases, bleeding can occur in the bowel, brain, and soft tissue

bleeding in these areas can cause throwing up blood, passing blood in stool, strokes, and severe pain in the joints or limbs which can cause nerve damage

Treatment

Most treatment is just adding FVIII or FIX (clotting factors) to the bloodstream.

75% of people with Hemophilia take a factor product to induce blood clots to prevent bleeding

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Classification

Single Gene

Sex-linked

X chromosome

Recessive

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Hemophilia A

Also known as factor VIII (FVIII) deficiency or classic hemophilia.

Hemophilia B

Also known as Christmas disease or factor IX (FIX) deficiency.

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"Frequently Asked Questions." About Hemophilia. WFH, May 2012. Web. 25 Feb. 2016.

"Hemophilia FAQs." Indiana Hemophilia & Thrombosis Center, Inc. Indiana Hemophilia & Thrombosis Center, Inc., n.d. Web. 25 Feb. 2016.

"Hemophilia." Genetics Home Reference. US National Library of Medicine, Aug. 2012. Web. 25 Feb. 2016.

"How Hemophilia Is Inherited." The Hemophilia, Von Willebrand Disease & Platelet Disorders Handbook. Hemophilia of Georgia, n.d. Web. 25 Feb. 2016.

"Learning About Hemophilia." Learning About Hemophilia. NIH, 27 Sept. 2011. Web. 25 Feb. 2016.

"National Hemophilia Foundation." Hemophilia B. National Hemophilia Foundation,  Web. 25 Feb. 2016.