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Piloting the temperature in the assay to be permissive for D. melanogaster.

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Maya Leonard - Temperature Preference of D. melanogaster During Parasitoid Wasp Infestation

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Maya Leonard - Temperature Preference of D. melanogaster During Parasitoid Wasp Infestation

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In Schlenke lab, I am working on two independent projects, the second of which is D. melanogaster (fruit fly) temperature preference changes during parasitoid wasp infestation. Invertebrates cannot control their body temperature during infection, commonly known as a "fever" in mammals. To combat this, many change their location to a place where the temperature can push out infection, called "self-fevering" or "self-freezing." Many pathogens can also behaviorally manipulate their hosts to go to temperatures that benefit pathogen propagation. Schlenke Lab specializes in parasitoid wasps, where temperature preference changes in their hosts have never been previously studied. This research can give better insight into adaptive behavioral defenses by invertebrates, as well as potential parasitic control by the wasps. As a student in Schlenke Lab, I'm currently working on engineering the temperature assay, including designing, building, and testing the system on which I will place my infested larvae to test their preferences.

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Generating heart rate and ethogram plots using MATLAB.

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Ava Pal - Evaluating the role of interoceptive signals in behavioral states and decision making

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Ava Pal - Evaluating the role of interoceptive signals in behavioral states and decision making

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In the Gothard Lab, I am evaluating the role of interoceptive afferent signals on decision making in monkeys. Interoceptive signals communicate the state of the body to the brain, and are expected to play a role in emotion and decision making. We designed an approach-avoidance task and used pharmacological manipulation to explore the causal role of a heightened sympathetic state on the monkey’s willingness to tolerate discomfort to receive a reward. During these experiments, we conducted electrophysiology recordings which I analyzed by isolating the neural signals from the noise. Additionally, I have developed an ethogram that I am using to analyze various behaviors that may be affected by a heightened sympathetic state during the experiment. My goal is to evaluate the relationship between the neural and behavioral states of the monkeys.

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Kaylee Kimbrell - Testing the PI3K/Akt Pathway in FGR Lamb Myoblasts

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Kaylee Kimbrell - Testing the PI3K/Akt Pathway in FGR Lamb Myoblasts

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In Limesand lab, I am working on a project aiming to identify if the PI3K/AKT pathway in fetal growth restricted (FGR) lamb myoblast cells is impairing the activity of TGFB. Continuing on from a project I helped with last summer, we now know that FGR lamb myoblasts are less affected by TGFB when compared to myoblasts from control (CON) lambs. We also have confirmed that the TGFB pathway is intact in both FGR and COM myoblasts using RNA Seq. data. As a result, we hypothesize the PI3K/AKT pathway is overactive in FGR myoblasts and as a results inhibits TGFB responsiveness. To prove this, I am treating myoblasts with PI3K and Akt inhibitors and will later use data from Western blots to analyze changes in protein expression across treatments. A lot of the work I have been doing this summer is proving my experimental design works with a lot of trial and error. I feel very fortunate to have the opportunity to explore all the ins and outs of designing an experiment that appropriately proves a hypothesis and look forward to seeing what all the data we've collected tells us about the PI3K/Akt pathway.

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Analyzing vocal data from bat flight experiments in Matlab.

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Ashiqul Alam - Optimization of active sensing under different environmental conditions

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Ashiqul Alam - Optimization of active sensing under different environmental conditions

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Animals must balance their needs, for example, between foraging and navigating. We study how the echolocating bat balances the energetic costs of flight with echolocation to understand how organisms optimize multiple goal-directed behaviors. In Dr. Wohlgemuth’s lab, I am looking deeper into the timing of the Big Brown and Freetail bats’ vocalizations with their wingbeats during flight in search of better understanding their active sensing optimization strategies using computational methods in Matlab. Some of the tasks include collection of experimental data of steady state flight from Freetail bats in clutter vs no-clutter environments, conversion and analysis of the audio data collected from microphones and wingbeat detection by keeping track of how their bodies rise and fall while flapping their wings with the aid of motion capturing sensors, and creating unique algorithms in Matlab to collect and visualize data.

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Audrey Thompson - Investigating the Effects of Maternal Obesity and DBP Exposure on Endothelial Cell Function

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Audrey Thompson - Investigating the Effects of Maternal Obesity and DBP Exposure on Endothelial Cell Function

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Maternal obesity is a known risk factor while pregnant, with offspring often exhibiting cardiovascular issues and higher blood pressure later in life. In Dr. Zhou’s lab, I am investigating the effect of diet-induced-maternal obesity on mice fetal-placental endothelial cells’ metabolic activities (i.e., lipid uptake capacity). The aim of this data analysis project is to further our understanding on how maternal obesity impacts fetal vascular/endothelial function, which is critical for the cardiovascular health of the offspring.

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Inspecting my recently converged discrete DFE fits.

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Lilith Kotler - Population Genetics of the Midas Cichlid Species Complex

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Lilith Kotler - Population Genetics of the Midas Cichlid Species Complex

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In the Gutenkunst lab, I use computational methods to study the evolution of the Midas cichlid species complex. First, I inferred the 1D demographic history of the populations of interest. Now, I am using that information to infer the distribution of fitness effects (DFE) for each population. The DFE quantifies the extent to which natural selection acts on a population, allowing us to estimate the selective effects of a new nonsynonymous mutation within a population. Once I have finished this, I will infer the joint demography of three population pairs. Then, I will infer the joint-DFE for each pair, which will allow us to determine how similarly, or dissimilarly, selection acts on the two populations.

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Working on a stochastic population genetic model for tetraploids and doing some theoretical reading.

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Sam Gibbon - Population Genetic Models for Polyploids

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Sam Gibbon - Population Genetic Models for Polyploids

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Many crops like potatoes, coffee, and strawberries are polyploid, meaning they have more than two sets of chromosomes—unlike humans, who are diploid. These extra chromosome copies make genetic processes more complex and poorly understood. My research uses mathematical models and computer simulations to study how polyploidy shapes long-term evolution through forces like mutation and natural selection. We’ve found that polyploidy can both hinder and enhance adaptation, depending on factors like inheritance mode and mutation bias. This work helps clarify how evolutionary dynamics unfold in polyploid species and lays the foundation for analyzing real-world genomic data.

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Measuring the level of cell confluence in a sample of breast cancer cells.

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Branham Carpenter - Measuring the Effects of Nutrient Deprivation on Chemotherapy Treatment

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Branham Carpenter - Measuring the Effects of Nutrient Deprivation on Chemotherapy Treatment

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In the Sutphin lab, I am performing research on how short-term nutrient depravation affects chemotherapy treatment for those suffering from cancer. We are using breast cancer in the experiments we are performing, and the drug that we are using is Tamoxifen, which is a known breast cancer chemotherapy drug. The analysis we are conducting helps to better understand the mechanisms behind cell preservation during moments of short-term and long-term stress, which may help future therapeutic strategies and improve outcomes for those going through chemotherapy treatment.

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Investigating Mutation Bias Reversal in Hypoxic Tumors

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Investigating Mutation Bias Reversal in Hypoxic Tumors

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In the Gutenkunst Lab, I am exploring how low oxygen (hypoxia) in tumors might change the way DNA mutations happen—and even reverse common patterns. Understanding this could reveal how cancer evolves and help improve treatments. My work combines biology and data science to uncover hidden patterns in cancer’s behavior.

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Testing protocol to quantify lipids from soil extracellular polymeric substance extractions

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Yvonne Kan – Analyzing Effects of Environmental Stressors and Microbial Diversity on Microbiome Biofilm Production

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Yvonne Kan – Analyzing Effects of Environmental Stressors and Microbial Diversity on Microbiome Biofilm Production

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Plant-microbiome interactions have potential to alter soil properties as well as boost plant growth. In the Favela Lab, we investigate the conditions in which microbes behave in a certain way and how we can use that information to build sustainable human systems. I manipulate soil microbiomes by altering microbial diversity and introducing drought stress in order to study soil microbes’ ability to produce extracellular polymeric substances (EPS). I also observe how this can affect functions such as water retention of soil and nutrient acquisition. We hope to use this information to increase plant productivity in water limited regions and improve agricultural practices in arid landscapes.

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Orli Sanyal-A Conceptual Model to Assess Barriers to Cancer Care for Native Americans in Rural Arizona

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Orli Sanyal-A Conceptual Model to Assess Barriers to Cancer Care for Native Americans in Rural Arizona

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In the Cancer Health Equity Lab, under the Guidance of Dr. Julie Armin, I am working to understand various factors that affect the process of Cancer Care for Native American Populations living in Southern Arizona. Specifically, I am screening predisposing factors such as Geographic isolation, extended wait times, and historic mistreatment by the healthcare system. This will be used to create a relationship between rurality and medical infrastructure to help identify factors that influence access to cervical and breast cancer diagnosis in Native American communities through a conceptual model based on the Behavioral Model for Vulnerable Populations through a socio-ecological framework. Once adapted by community partners, it can be used to build a statistical model.

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Analyzing seeds stained with tetrazolium to assess for viability.

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Annika Gooding - Testing the Viability and Germination Rates of Invasive Stinknet

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Annika Gooding - Testing the Viability and Germination Rates of Invasive Stinknet

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The FunEco Lab uses a trait-based approach to exploring species and ecosystem functions, especially in response to climate change and human disturbance. My project focuses on the invasive weed Oncosiphon pilulifer, or stinknet. A single stinknet plant can produce thousands of seeds, and my research seeks to determine how many of those seeds are living/viable, how many are dormant, and if those rates are impacted by high temperature. Despite its prevalence, little is known about stinknet beyond the clear threat it poses to native species. This research can inform future management strategies, and the long-term risks of dormant seeds remaining in the seedbank and causing reemergence even after the mature plant is removed.

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Analyzing seeds stained with tetrazolium to assess for viability 

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Helping maintain Arabidopsis thaliana samples for continued experimentation.

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Alex Tesch - ANX 1/2 and BUPS 1 Evolution and Contribution to Plant Reproduction

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Alex Tesch - ANX 1/2 and BUPS 1 Evolution and Contribution to Plant Reproduction

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In Dr. Beilstein’s lab, I am investigating the evolution and function of receptor-like kinases (RLKs) BUPS1 and ANX1/2, and their contributions to cell wall integrity and pollen tube growth in Arabidopsis thaliana. An increased understanding of these RLKs will provide fundamental insights into plant reproduction and the molecular mechanisms underlying cell-to-cell communication.

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Nikhil Johnson - Investigating the patency of coronary artery bypass grafts based on nitric oxide synthase activity. 

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Nikhil Johnson - Investigating the patency of coronary artery bypass grafts based on nitric oxide synthase activity. 

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In the Kazui lab, I am working on several projects to make coronary bypass surgery safer and more effective. This work allows me to partake in diverse research, from collecting graft and blood samples in the OR, working in the wet lab with ELISAs and cell cultures, and even dry lab analysis of patient chart reviews. First, I am studying different heart-protecting solutions called cardioplegia, which temporarily stops the heart during surgery. By comparing how these solutions affect the heart’s mitochondria, I hope to find the best way to protect heart cells during operations. Second, I am developing a better way to test whether a patient’s radial artery can be safely used as a bypass graft without risking poor blood flow to the hand. Finally, I am analyzing why some bypass grafts work better than others, and studying a natural substance called nitric oxide synthase, which is a marker for healthy blood vessels, to see how its levels differ between arteries and veins used in surgery. This could one day lead to treatments that make grafts last longer and help patients recover better.

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Arjan Kundan - CGRP-Driven Hyperinnervation in Zymosan-Induced Vulvodynia: From Mechanism to Therapy

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Arjan Kundan - CGRP-Driven Hyperinnervation in Zymosan-Induced Vulvodynia: From Mechanism to Therapy

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In Dr. Porreca’s lab we model vulvodynia by giving female mice repeated “yeast-like” exposures with zymosan, a harmless particle from yeast cell walls. After each exposure we test pain with von Frey filaments—a gentle poke that reveals how sensitive the vulva has become. One week after the final dose we collect the vulva, dorsal-root ganglia (DRG), and spinal cord, freeze the tissue, cut it into hair-thin slices with a cryostat, and place the slices on microscope slides. Routine H&E staining shows overall structure and any lingering inflammation, while immunohistochemistry (IHC) uses antibodies to light up key molecules. In these stained sections we see many more CGRP-positive nerve fibers, activated mast cells, and pro-inflammatory cytokines, proving that the nerves stay overactive even after visible inflammation fades.

Because CGRP (Calcitonin Gene-Related Peptide) is already a proven pain signal in migraines, we suspect it is also a main driver of vulvar pain. Our next step is simple but powerful: give the mice a CGRP antagonist once this extra nerve growth (hyperinnervation) is established and see whether their pain responses drop. If blocking CGRP reduces pain, we will have clear evidence that the peptide is not just present but functionally causing hypersensitivity. Success would make CGRP-targeted therapy a promising, mechanism-based option for women with vulvodynia—an area where effective treatments are urgently needed.

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Presentation at the Annual CBC Undergraduate Poster Fair 2025

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Dylan Weaver – Adding Fluorine into Biomolecules Using Photochemistry

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Dylan Weaver – Adding Fluorine into Biomolecules Using Photochemistry

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In Dr. Michael Taylor’s lab, we research molecules with specific groups that can detach and reattach to biomolecules upon exposure to certain wavelengths of light. I am specifically working on a molecule that has a leaving group with nine fluorine atoms. When attached to biomolecules, this fluorine group can impart unique properties that can make biomolecules better drugs.

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Loading samples into wells for a Western blot!

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Serena Yañez - Cell-type specific response to GPR143 activation 

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Serena Yañez - Cell-type specific response to GPR143 activation 

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In Dr. Brian McKay's lab we studying blinding eye diseases, such as Age-Related Macular Degeneration (AMD) , the leading cause of irreversible blindness in the world. Our lab found that the activation of GPR143, a G-coupled protein receptor, by L-DOPA has proven to be an effective treatment of wet AMD in patients. My project specifically, investigates further the activity of GPR143 in pigmented cell types in the eye to better understand the role pigmentation plays in the disease, as race affects AMD incidence. To do so, I isolate and analyze extracellular vesicle (EV) populations from cell cultures along with using various protein chemistry techniques to understand how and why the activation of this receptor by the same ligand has very different responses in different cell types, why there is a cell-specific response. By understanding the activity of GPR143 better, there can be further developments in treatment that are not only more easily accessible, but effective in all patient populations.

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Using syringe pumps and a microscope to encapsulate polymyxin B in droplets for later analysis.

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Riley Greenleaf - Development of a microfluidic drug screening platform for compound encapsulation and analysis

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Riley Greenleaf - Development of a microfluidic drug screening platform for compound encapsulation and analysis

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In the Streicher/Cartmell lab, I am engineering a drug screening platform using a droplet-based system called microfluidics to encapsulate compounds within a small water-in-oil droplet. Using the fluorescent properties of certain proteins, we can sort the compounds once they are encapsulated into a droplet. We can also use this system to analyze the natural products produced by these compounds, allowing them to metabolize within encapsulations. This can lead to the discovery of new bioactive compounds and allow for analysis of their properties and therapeutic potential. These techniques allow drug screening to happen on a smaller scale, lowering costs for researchers and making the analysis process less resource-intensive.

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Isabella Irby - Copper Crossroads: Exploring the Immune Response to Copper Stress in C. elegans

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Isabella Irby - Copper Crossroads: Exploring the Immune Response to Copper Stress in C. elegans

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In the Sutphin Lab, I am conducting research on how environmental stressors, particularly heavy metals like copper, influence immune function and aging. My project focuses on the paradoxical role of copper, which is toxic in high doses but essential in small amounts, especially for maintaining immune health.

We are using Caenorhabditis elegans as a model organism to study how exposure to copper sulfate (CuSO₄) affects the body’s ability to respond to stress and infection. Through transcriptomic analysis and PANDA network inference, we have identified key transcription factors and immune-related genes activated by copper exposure. Our findings suggest that copper triggers protective immune pathways, potentially involving the kynurenine pathway, which we are investigating further to understand its role in immune regulation.

This research aims to better understand how heavy metal exposure shapes immune aging and stress resilience. By identifying genetic pathways involved in this response, we hope to uncover new therapeutic targets that could help enhance health and immunity in aging populations, particularly in areas like Arizona where age-related diseases are on the rise.

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Using confocal microscopy to visualize which parts of the tissue are alive versus dead on day 8 of the culture.

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Ethan Lin - Perfused LLS Microgel 3D Bioreactor for Patient Tumor Explants: A Multi-Modal Analysis Pipeline for Personalized Oncology

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Ethan Lin - Perfused LLS Microgel 3D Bioreactor for Patient Tumor Explants: A Multi-Modal Analysis Pipeline for Personalized Oncology

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In Dr. McGhee’s lab, we are developing a novel tissue processing and culture pipeline that enables ex vivo (out of body) maintenance and monitoring of patient biopsies for precision medicine applications. Currently, I am optimizing the procedure of processing mouse lung tissue and culturing it in a 3D microfluidic chip which contains a liquid-like solid (LLS) microgel matrix. Uniquely, this granular microgel environment provides mechanical support to hold the tissue in place while allowing flexibility for growth and movement. Additionally, this system permits perfusion, mimicking a capillary bed to supply nutrients and remove waste. To assess the tissue system's viability, I am using confocal microscopy (lasers to image cells). I also assist in developing the various components of the system including LLS and microfluidic chips. With this platform, we can conduct various tests to guide personalized therapy decisions by predicting treatment efficacy and uncovering targetable tumor vulnerabilities.

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Determining sources of error for phosphorus analysis assay for lipid-to-protein ratio. 

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Tiffany Luu (Brown Lab): Flexible Surface and Energy Landscape Models in Rhodopsin G Protein-Coupled Receptor Activation

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Tiffany Luu (Brown Lab): Flexible Surface and Energy Landscape Models in Rhodopsin G Protein-Coupled Receptor Activation

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About one-third of pharmaceutical drugs target G protein-coupled receptors (GPCRs). GPCRs are membrane proteins that receive signals, initiating a signal cascade and biological response. Using prototypical GPCR Rhodopsin, I assist in investigating GPCR activation in different lipid and water environments using Ultraviolet–Visible Spectroscopy, Excel data analysis, and other techniques.

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Isolating reaction product with column chromatography for later use in molecular probe. 

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Thomas Oldham- Identify key proteins in mosquito larvae midgut that can be exploited for future insecticide targets

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Thomas Oldham- Identify key proteins in mosquito larvae midgut that can be exploited for future insecticide targets

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In Dr. Jewett's lab, the overall goal of the research is to use bioorganic chemical techniques to selectively kill mosquito larvae using small-molecule probes that can bind to the larvae’s basic midgut. I use techniques of organic synthesis, mosquito larvae dissections, performing toxicity assays, SDS- Polyacrylamide Gel Electrophoresis, Western Blotting, and making lysates to study mosquitos with the overall goal of combatting the spread of deadly diseases from mosquitos. Most of my research focuses on studying proteins in the midgut of the mosquito larvae, for future targets of insecticides. The specific proteins and much of the mosquito’s midgut proteome are unknown, so this research will hopefully identify the key proteins that can be exploited for future insecticide targets.

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Preparing DNA extraction samples for Qubit analysis

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Mahriza P.Manriquez - Host-microbe dynamics and co-infection interactions of an emerging tick-borne zoonosis

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Mahriza P.Manriquez - Host-microbe dynamics and co-infection interactions of an emerging tick-borne zoonosis

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In the McNew Lab, I am working on a project that explores the interactions between a host/vector and a microbe as well as the interactions of different co-infections within the host/vector. Interactions between microbes and their hosts  can tell us about how the microbe survives and transmits. The interactions between different pathogens can include competition, cooperation and coexistence. Within these interactions, we can observe how virulence, transmission, and inhibition are impacted and their effects on their host/vector.

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Mackenzie Lynch - Investigating the role of interoceptive signals on social learning and decision making in rhesus macaques

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Mackenzie Lynch - Investigating the role of interoceptive signals on social learning and decision making in rhesus macaques

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In the Gothard Lab, I am looking into how interoceptive signals impact social learning mechanisms in the brain. Interoceptive signals communicate the state of the body to the brain, and we hypothesize they will have an effect on learning. Using monkeys, a species highly reliant on social relationships for quality of life, we created visual interactions between two unknown monkeys and tasked our own monkeys with viewing the interaction and learning the social status of each individual. To see whether a heightened physiological state would impact how our monkey learns these social relationships, we are using pharmacological manipulation to increase heart rate. Just like the monkeys, I am learning so much in the lab and am looking forward to the rest of the summer doing experiments and data analysis.

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Practicing aligning the coil for Theta Burst Stimulation, a patterned form of TMS, on lab member Hannah Siu.

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Carol Chen - Investigating the Usage of Transcranial Magnetic Stimulation for Cognitive Enhancement in Mild Cognitive Impairment

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Carol Chen - Investigating the Usage of Transcranial Magnetic Stimulation for Cognitive Enhancement in Mild Cognitive Impairment

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In Dr. Ying-Hui Chou’s Lab, I am investigating the applications of Transcranial Magnetic Stimulation (TMS), which is a non-invasive technique that uses magnetic fields to influence brain activity and connectivity. Mild Cognitive Impairment (MCI) is an intermediate stage between condition between normal aging and dementia. TMS is emerging as a promising therapeutic tool for memory and learning. Specifically, my work involves analyzing how the order of different TMS protocols, participants' genetic risk factors, and their performance on memory and neuropsychological tests relate to treatment outcomes. I also help collect data for a related project exploring how transcutaneous auricular Vagus Nerve Stimulation (ta-VNS) may enhance brain plasticity and boost the effects of TMS.

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Measuring samples to analyze protein concentrations linked to cellular stress.

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Adam Super - Tracking Cellular Stress in Cardiomyocytes with CPVT

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Adam Super - Tracking Cellular Stress in Cardiomyocytes with CPVT

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I research ventricular heart disease in the Hamilton Lab, focusing on a rare genetic condition that disrupts calcium signaling in cardiomyocytes (heart cells). This can lead to arrhythmias, seizures, and sudden death, often in children and young adults. Using healthy and diseased rat models, I study how cell stress triggers a rare form of ventricular tachycardia. Through biochemistry and imaging, I analyze certain proteins and organelles as stress markers, which are key to understanding how this disease manifests.

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Preparing brainstem sample for OCT imaging 

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Victor Sandrin - Utilizing Diffusion MRI Data to Compare Tractography Models of Cranial Nerves and Brainstem Structure

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Victor Sandrin - Utilizing Diffusion MRI Data to Compare Tractography Models of Cranial Nerves and Brainstem Structure

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In the Hutchinson Lab, I am analyzing quantifiable metrics of structural connectivity in the brain using a technique called tractography. Tractography uses data from magnetic resonance imaging to model white matter connections within and between brain regions. In my current project, I am utilizing tractography to identify cranial nerves in the brainstem and compare how they are modeled across different tractography programs. Due to the complexity and difficulty of modeling these tracts accurately, new tractography methods must be developed and validated for effective use through testing such as this. I then use these maps of white matter connections (tractograms) to compare with the actual white matter tracts in the brainstem sample that we can identify using optical coherence tomography (OCT) in order to validate our tractography methods.

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Kaia Mount - Investigating the Role of TORC1 and PKA Signaling in Translation Initiation Factors During Cellular Stress

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Kaia Mount - Investigating the Role of TORC1 and PKA Signaling in Translation Initiation Factors During Cellular Stress

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While much is known about how cells function under optimal, homeostatic conditions, far less is understood about how they respond to stress and nutrient deprivation. The Capaldi Lab investigates how cells detect and respond to these challenges, particularly through the TORC1 (Target of Rapamycin Complex 1) signaling pathway in yeast. Using fluorescence microscopy and western blotting, I study how various translation initiation proteins respond to different stressors, with a focus on their roles in the TORC1 and PKA (Protein Kinase A) pathways. The ultimate goal of this work is to uncover fundamental biological mechanisms that regulate cell growth and survival, with the long-term aim of identifying potential therapeutic targets relevant to cancer biology.

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Jacob Lines - Analyzing Genomic Data and Chromosome Structures in Drosophila Compound X Chromosomes.

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Jacob Lines - Analyzing Genomic Data and Chromosome Structures in Drosophila Compound X Chromosomes.

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In Dr. Keith Maggert’s laboratory, I conduct research that uses CRISPR to mutate fruit flies for our experiments and analyze the structure of compound chromosomes. One of my projects involves using CRISPR to mutant fruit fly eyes from red to white for use in experiments with epigenetic regulation in the eyes. After the mutations take place, I look at the genomic data and sequence it in order to characterize the nature of the mutations. My other project involves looking at tissue squashes underneath a fluorescence microscope to identify chromosome structures in various compound chromosomes. This research is used to better understand how mistakes in chromosome separation occur, which has implications for various genetic diseases and in cancer formation.

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Analyzing reflectance peaks from a method test for lipid membrane-receptor fragments to probe for drug dose response

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Adrian De la Pena - Optimized Drug Design at GPCR receptors using plasmon waveguide resonance spectroscopy

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Adrian De la Pena - Optimized Drug Design at GPCR receptors using plasmon waveguide resonance spectroscopy

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The Cai Lab, run by Dr. Minying Cai, focuses on novel GPCR based drug design and discovery by way of structure-activity relationships and upcoming bioinformatics. We specialize in testing drug-receptor binding and cellular signal assays.

One of our unique developed methods is a form of SPR called plasmon waveguide resonance spectroscopy, which uses light reflectance off of a prism that contains a proteolipid system to measure mass distribution changes of the system. The lab also focuses on using molecular modeling to identify evolutionary relationships between points on receptors--called coevolution--to pinpoint more effective drug designs.

Our research aims to identify potential drug candidates and understand more about how certain receptor subtypes react to drugs to better understand their role in physiological processes. As the first step in identifying potential life-saving drugs, we work to effectively qualify the efficacy of new compounds and refine methods to find new ones.

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Conducting time lapse imaging of live endometrial stromal cells during decidualization. The protein FOXO1 is labeled with red fluorescent protein (RFP).

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Kylie Ernst - Transcription Factor Activation During Decidualization of Endometrial Cells 

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Kylie Ernst - Transcription Factor Activation During Decidualization of Endometrial Cells 

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My research project in the Paek lab aims to give insight into the causes of disorders like endometriosis and infertility. I want to understand the biochemical changes that endometrial cells undergo during a normal menstrual cycle. Throughout this process, called decidualization, I’m exploring the activation dynamics of two proteins that regulate the cell cycle.

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Pipetting DNA samples into the NanoDrop to check for concentrations and purity

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Angelina Nediyathu - Investigating Oxytocin Response and Genetic Factors in Postpartum Hemorrhage

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Angelina Nediyathu - Investigating Oxytocin Response and Genetic Factors in Postpartum Hemorrhage

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In the MuMH (Mechanisms Underpinning Maternal Health) lab, under the guidance of Dr. Elise Erickson, I contribute to research focused on understanding why some birthing people experience unexpected postpartum hemorrhage (PPH), even in the absence of risk factors. As part of the PARTO (Predicting Adequate Response to Oxytocin) study, I perform DNA isolation from saliva and cheek swab samples, as well as abstract clinical data from medical records. Our research investigates how genetic and epigenetic differences may affect the body’s response to oxytocin, a common medication used to induce labor and prevent hemorrhage after birth. This work aims to improve our ability to predict and prevent postpartum complications. I am also conducting a literature review exploring how ultrasound imaging is used to assess abnormal placental attachment before delivery.

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Assessing confluence of 293T cells prior to transfection

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Nancy Elnady - Identifying the Functions of Solute Carriers

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Nancy Elnady - Identifying the Functions of Solute Carriers

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Solute carriers (SLCs) are a large family of membrane proteins that transport a wide range of molecules across the cell membrane. While many SLCs have well-defined functions, a significant number remain uncharacterized.

In the Bhattacharya lab, I am working on a project aimed at identifying the functions of these orphan transporters. To do this, I use CRISPR-Cas9 to knock out candidate genes in 293T cells and analyze resulting changes in metabolite levels to infer each SLC’s role.

Understanding how these transporters influence metabolism is especially important in cancer, where cells often reprogram metabolic pathways to support tumor growth. By uncovering the functions of some SLCs, this work may reveal new therapeutic targets and provide insight into the metabolic adaptations that drive cancer progression.

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Counting cytospin percentages on the lab microscope with a C57Bl/6 model mouse

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Ella Harris – Elucidating a role for protease-activated receptor-2 (PAR-2) antagonist in the control of asthma.

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Ella Harris – Elucidating a role for protease-activated receptor-2 (PAR-2) antagonist in the control of asthma.

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I work in the lab of Dr. Scott Boitano of the Asthma and Airway Disease Research Center and Department of Physiology at the University of Arizona. I am working with immortalized and primary cultured airway epithelial cell lines (in vitro) and humanized C57Bl/6 mice (in vivo) models to test and develop novel PAR2 antagonists that can be used to control allergic asthma. With the effects in vitro models I use standard and unique cell and molecular biology methods to identify and characterize unique PAR2 antagonists. With the in vivo models I use allergens to induce airway hyperresponsiveness, airway inflammation and mucus overproduction and evaluate if administration of PAR2 antagonists control these allergen-induced responses. The goal is to develop novel drug candidates for the treatment of to relieve allergy induced asthma that can eventually be tested in humans.

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Dissecting blood-fed mosquitoes for total RNA isolation

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Iris Lyman - Evaluating pantothenate kinase expression in genetically engineered mosquitoes 

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Iris Lyman - Evaluating pantothenate kinase expression in genetically engineered mosquitoes 

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In the Riehle lab, I am working on a project that analyzes the transcription, translation, and protein activity level of pantothenate kinase (PanK) in our genetically engineered line of mosquitos. PanK allows pantothenate (Vitamin B5) to move on to the next step of coenzyme A (CoA) synthesis, making it a vital enzyme for mosquitoes, malaria parasites, and other organisms. By overexpressing PanK in our mosquitoes, we expect to see a decrease in pantothenate levels and an increase in the level of CoA in mosquito samples. Understanding how the overexpression of transgenic PanK affects the levels of pantothenate in mosquitoes may allow us to decrease its availability to malaria parasites, thus starving them.

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Aparna Chandrasekar - Analyzing the Buildup of Total Bile Acids levels in infants with Necrotizing Enterocolitis

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Aparna Chandrasekar - Analyzing the Buildup of Total Bile Acids levels in infants with Necrotizing Enterocolitis

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In Dr. Halpern's neonatology lab, I work to investigate the connection between an excess level of total bile acid levels in an infant's fecal samples and the presence of necrotizing enterocolitis in their bodies. I work to extract the aqueous layer of homogenized fecal samples from the NICU and test for the presence of bile acids within each sample, so we can determine whether there is a change in the level of bile acids over the infant's days of life. In doing so, my lab hopes to find a mechanism to detect buildup of bile acids in infants during their first few days of life. The end goal is to develop a more accurate and effective marker using bile acids to determine when an infant may develop necrotizing enterocolitis.

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Analyzing protein family phylogenetic trees, and creating a maximum likelihood function using Cogent3 in python.

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Vincent Carter - Using non-stationary substitution models to determine amino acid frequencies in LUCA vs. present day bacteria and archaea

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Vincent Carter - Using non-stationary substitution models to determine amino acid frequencies in LUCA vs. present day bacteria and archaea

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In the Masel Lab, I am studying how proteins have evolved across earth's history. We use evolutionary models to infer how amino acid usage has changed since the last universal common ancestor of life on earth (LUCA). For my project, I am using the languages Python and R to determine which amino acids were used more by LUCA, and then compare these frequencies to modern bacteria and archaea. This will help us understand what early life was like and how the genetic code evolved.

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Katelyn Clarke - Looking for Nonlipogenic ABCA1 inducers to treat Alzheimer's disease and related diseases.  

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Katelyn Clarke - Looking for Nonlipogenic ABCA1 inducers to treat Alzheimer's disease and related diseases.  

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Previous studies show that ABCA1 reduces amyloid beta plaques in Alzheimer’s by transporting cholesterol out of the brain, activating the protein APOE to remove the plaque. However, its regulator, LXR, also activates SREBP1c, which promotes lipogenesis in the liver. In the Thatcher lab, I help identify drugs that induce ABCA1 and correctors that inhibit SREBP1c by using PCR and luciferase assays.

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Dakota Anderson- Exploring How Hormones in Females Affect Neurogenesis

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Dakota Anderson- Exploring How Hormones in Females Affect Neurogenesis

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The Madhavan Lab has previously explored how aging influences the brain’s ability to generate new neurons (neurogenesis) in male rat models. We are now examining how female hormones, specifically estrogen and progesterone, influence neurogenesis at various stages of life. Using ovariectomized female rat models, we assess both cellular and behavioral outcomes related to hormone-driven neural changes. This project aims to clarify how hormonal shifts across the female lifespan shape brain plasticity and cognitive health.

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Ishnoor Sandhu pipetting media with viral particles containing a plasmid coding for a cleavable ∝6β1 integrin that can be induced with an exogenous enzyme. The media is being added to pancreatic and colon cancer cell lines to transfect them | Cress Lab | UA Cancer Center

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Ishnoor Sandhu - Investigating How ∝6β1 Integrin Clipping Drives Prostate Cancer Metastasis

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Ishnoor Sandhu - Investigating How ∝6β1 Integrin Clipping Drives Prostate Cancer Metastasis

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Patients with localized prostate cancer (PCa) have a ~99% survival rate after 5 years. That number decreases to ~33% once PCa has migrated to distant sites in the body, a process called metastasis. In Dr. Anne Cress' Lab, I am interested in investigating how cell-surface adhesion receptors, called integrins, drives PCa invasion and metastasis via their interactions with other cells and the extracellular matrix. Integrins are heterodimers made up of an alpha and beta subunit. When the alpha subunit of the ∝6β1 integrin is clipped, it act as a “switch” that causes PCa to become more migratory and aggressive. My project is focused on using novel biosensors to determine the activation of specific pathways to drive PCa metastasis. Discovering the significance of this post-translational modification in PCa is also relevant to understanding other cancers, which can allow scientists to develop more effective therapeutics, prevent metastatic disease, and increase cancer patient survivability.

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Presenting a poster on my research at the 3rd Joint Congress on Evolutionary Biology

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Micaila Marcelle - Investigating the effects of background selection on site frequency spectra under human-realistic parameters

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Micaila Marcelle - Investigating the effects of background selection on site frequency spectra under human-realistic parameters

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The neutral theory of molecular evolution predicts a certain pattern in the number of common vs. rare neutral alleles in a population. Selection against other, deleterious mutations can disrupt this pattern via the process of background selection. My research in the Masel lab focuses on characterizing such disruptions under human-realistic parameters.

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Maximo Mondragon - Surface Modification of Biocompatible Material for Osseosurface Implantable Electronics and Subsequent In Vivo Characterization of Bone Growth using X-ray and CT Imaging

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Maximo Mondragon - Surface Modification of Biocompatible Material for Osseosurface Implantable Electronics and Subsequent In Vivo Characterization of Bone Growth using X-ray and CT Imaging

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In Dr. Margolis's lab we research and develop osseosurface implantable electronics which are designed to measure in-vivo strain and thermal conductivity in rodent and sheep models to track bone healing after surgical procedures, measure long-term bone strain, and potentially detect osteoporosis.

My specific project focuses on modifying and optimizing the surface chemistry of the device's primary material, polyimide. The goal is to retain its biocompatibility and improve its adhesive ability with connective tissue while promoting bone growth. To explore this, I’ve tested surface modification techniques such as plasma treatment as well as layered coatings of (3-Aminopropyl)triethoxysilane (APTES), polydopamine (PDA), hydroxyapatite (HA), and Bone Morphogenetic Protein 2 (BMP-2). These modified surfaces are then characterized using techniques such as Fourier Transform Infrared Spectroscopy (FTIR), Atomic Force Microscopy (AFM), X-ray Photoelectron Spectroscopy (XPS), and Scanning Electron Microscopy (SEM). After characterization, the modified devices will be implanted and tested in in-vivo models to determine their reliability and to evaluate new bone growth through analysis of CT scanning and X-ray images.

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Working in a protocol to test if the hydrogels are functional for cells to attach. 

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Cris Angeles - Synthesizing functional hydrogels for cell culture

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Cris Angeles - Synthesizing functional hydrogels for cell culture

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In Mcghee lab, I am focused in synthesizing a functional hydrogel that cells can attach to and live. Hydrogels (as the name suggests) are gel-like structures that can absorb great amounts of water, more important, can be use for cells to grow on it by attaching. This opens a path to grow cancer cells and study them for medical purposes, and the possibility of bio-printing organs and tissue in a near future.

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Inserting sample into HPLC for purification

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Logan Olshan - Optimization of an Amide Coupling Reaction

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Logan Olshan - Optimization of an Amide Coupling Reaction

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The goal of my project is to optimize a reaction that couples an amide onto a peptide. The amide coupling allows for creation of a vast number of small molecules which allows for the usage of DNA encoded libraries: a high throughput screening method to quickly find molecules for drug discovery.

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Using R to clean the data, create analytic variables, and run descriptive and regression analyses for the CHD mental health study.

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Marla Rivas - Exploring Mental Health Outcomes in Congenital Heart Disease 

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Marla Rivas - Exploring Mental Health Outcomes in Congenital Heart Disease 

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I'm currently working in the ARID Lab, where I'm contributing to a public health surveillance project focused on individuals with congenital heart defects (CHD). My main role involves preparing and analyzing a large, multisource dataset to explore mental health outcomes, specifically anxiety, depression, and other conditions among adolescents and adults with CHD. This includes identifying relevant diagnoses using ICD-9 and ICD-10 codes, applying strict exclusion criteria to focus on adult-onset mental health issues, and integrating demographic, clinical, and geographic data.

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Preparing to transfect HEK 293T with a tumor infiltrating antibody plasmid

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Dani Khatib - Producing Tumor Infiltrating mAbs and Bispecific Antibodies

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Dani Khatib - Producing Tumor Infiltrating mAbs and Bispecific Antibodies

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The human immune system can eliminate cancer cells through the production of antibodies that bind too them, marking them for destruction. At the Bhattacharya lab, my work focuses on determining the specific epitopes that these tumor infiltrating antibodies bind to. Identifying the cell surface markers that help distinguish healthy cells from cancerous ones can uncover the fundamental processes to break the immune system's self-tolerance. Additionally, I am working on producing bispecific antibodies that can bind to two separate antigens for specific drug delivery. Both of my aforementioned research projects focus on developing potential immunotherapeutic treatments to combat cancer. As opposed to chemotherapy or radio therapy—which target rapidly dividing cells within the body and inevitably harm healthy cell—immunotherapy allows for an incredibly specific elimination of cancer cells due to the immense specificity of antibodies.

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Ria Siddaiah - Investigating the Function of HPV’s Minor Capsid Protein L2 in Supporting Infection. 

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Ria Siddaiah - Investigating the Function of HPV’s Minor Capsid Protein L2 in Supporting Infection. 

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Human papillomaviruses (HPVs) are among the most prevalent sexually transmitted infections and are responsible for causing 5% of cancers worldwide, and nearly all cervical cancers. In order to successfully infect a human cell, HPV’s DNA must travel through the cell to reach the nucleus. It is known that HPV’s minor capsid protein— L2— acts as a chaperone for the viral genome between the cell surface and nucleus. In Dr. Campos’ Lab, my project aims to understand how L2’s ability to support infection and other characteristics are impacted by the addition of different sized tags at the C-terminus.

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Loading cells into a counting slide in order to determine the cell count of my lifted cells

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Kyle Kelly - Effect of Prenatal DBP Exposure on Cell Proliferation in Placenta

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Kyle Kelly - Effect of Prenatal DBP Exposure on Cell Proliferation in Placenta

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Dibutyl Phthalate (DBP), a phthalate congener, is an endocrine disruptor commonly found in consumer goods and medications. Due to their vast presence in the environment, women of reproductive age are prone to DBP exposure. Although prenatal DBP exposure is associated with adverse pregnancy outcomes in offspring, the effect of DBP exposure on fetal-placental endothelial function on a cellular and molecular level is unclear. In Dr. Zhou’s lab, I am conducting an immunohistochemistry (IHC) analysis of placentas from fetuses with prenatal exposure to low levels of DBP that simulate the amount of DBP exposure from our environment. This consists of analyzing cell proliferation markers (such as the Ki67 and PCNA proteins) in placental tissue from gestational day 18.5 (corresponding to the end of the 3rd trimester in humans). In doing so, we can reach a better understanding of the mechanism in which environmentally-relevant DBP exposure impacts placental function, a stepping stone in understanding the effects of prenatal DBP exposure on the cardiovascular and metabolic health of offspring.

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Sarah Rubinstein- Intestine Specific DRP1 Knockout Confers Colitis Resistance in Mice 

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Sarah Rubinstein- Intestine Specific DRP1 Knockout Confers Colitis Resistance in Mice 

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My research helps explain the gap in existing scholarship, as the role of mitochondrial fission in inflammatory bowel diseases has yet to be fully explored. Some therapies target inflammation directly, but there are few approved treatments that address mitochondrial function. Therefore, my research helps to analyze how manipulating mitochondrial fission could potentially offer a new therapeutic target for inflammatory bowel diseases and potentially other inflammatory diseases.

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Running a simulation on Ansys HFSS to compare the performance of different array geometry and circuit components. 

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Alvaro Cruz Perez - Development of Ferret-Specific MRI Equipment and Behavioral Analysis Tools for Brain MRI Studies

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Alvaro Cruz Perez - Development of Ferret-Specific MRI Equipment and Behavioral Analysis Tools for Brain MRI Studies

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In Dr. Hutchinson’s Multi-Scale Brain Imaging Lab (MSBIL), our research aims to develop accurate maps of microscale cellular and physiological features throughout the brain, searching for noninvasive markers of brain pathology. We primarily utilize diffusion MRI in preclinical and translational models of both healthy and pathological brains. I am part of a project that aims to introduce ferrets as preclinical models for MRI studies in aging-related studies. We collect both imaging and behavioral data as an effort to strengthen our findings and facilitate their translation. I am currently wrapping up the development of a ferret MRI cradle that solved the challenges we encountered due to the size differences between each subject and between sexes. As I wrap up, I am starting to explore the design of a ferret-specific RF coil that could solve the limitations of available MRI coils, increasing the quality of the signal by adding flexibility (to adapt better to different sizes) and multiple receiving channels (greater signal strength). I also support behavioral data collection by conducting tests, recording data, and developing a machine learning-powered behavior classifier for a more efficient analysis.

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Collecting A2aR DNA for CRISPR/Cas9 injections

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Mariah Bime - Identifying the Signaling Pathways of Terpene Compounds and Their Impact on Morphine Reward in Chronic Pain

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Mariah Bime - Identifying the Signaling Pathways of Terpene Compounds and Their Impact on Morphine Reward in Chronic Pain

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Chronic pain is typically managed utilizing opioid pain medications, which have negative side effects such as addiction and dependence. In the Streicher lab, one of the projects I have been working on involves the use of the terpene beta-caryophyllene (BCP), a compound typically found in cannabis. The lab explores the terpene signaling pathways and their role when coadministered with morphine to treat chronic pain. To do so, I work with my mentors to administer CRISPR/Cas9 to mice using ICV cannulation, a surgery that allows us to inject it through the brain. Then I use conditioned place preference (CPP) to measure the rewarding effect of opioids on their own as compared to opioids when combined with terpenes. The goal of these experiments is to utilize these terpenes, such as BCP, in combination with opioids to minimize the rewarding effects, avoiding fatal consequences for many patients.

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Arabella Andrade-Sanchez - The Hidden Burden of CVD Risk in Navajo Adults: Findings from a Community-Based Sample

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Arabella Andrade-Sanchez - The Hidden Burden of CVD Risk in Navajo Adults: Findings from a Community-Based Sample

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In Dr. Garcia's Lab, I work with the rest of the Nosotros Comprometidos A Su Salud team to study cardiovascular and liver health and disease prevention in Native American and Mexican populations. Despite Mexican origin communities facing higher risks of obesity, diabetes, and Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease (NAFLD), little is known about which social factors and stressors contribute to this outcome. My project under NACP has been studying heart disease risk prevalence in the Navajo Nation by analyzing level of physical activity, sleep, blood pressure, diabetes, and other physiological markers. I help collect data for various studies being done in the lab by drawing blood, walking participants through consent forms, conducting the FibroScan on participants, as well as discussing their results with them. This work helps to identify gaps in metabolic disease prevention for Indigenous communities.

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Navya Balaji - Evaluating PAR-2 Antagonists to Develop Asthma Reducing Compounds 

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Navya Balaji - Evaluating PAR-2 Antagonists to Develop Asthma Reducing Compounds 

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In the Respiratory Cellular Physiology Laboratory, I am working on understanding lung epithelial biology and its critical role in maintaining lung health in asthma. I am using in vitro and in vivo techniques to evaluate whether protease-activated receptor-2 (PAR2) can be targeted for novel treatments of allergy-induced asthma, and with the work I have done in this lab, I have learned to culture an immortalized human airway epithelial cell line that natively expresses PAR2 and am currently learning how to establish primary cultures of airway epithelial cells from multiple mouse models. These cultures will be used to evaluate the effects of PAR2 antagonists on cellular signaling processes. I have also learned to establish allergic asthma in mouse models and how to record allergen-induced changes in airway hyperresponsiveness and airway inflammation, key indicators of allergic asthma, and by doing this, I have seen that PAR2 antagonists can limit these allergen-induced changes in animals. By screening and testing PAR2 antagonists, we aim to develop novel compounds that can reduce airway hyperresponsiveness and inflammation associated with allergy-induced asthma in humans.

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Creating slides using an acetate peel of the hinge of a clam.

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Delia Riley - Northeastern Pacific Climate Reconstruction

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Delia Riley - Northeastern Pacific Climate Reconstruction

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Working in Dr. Black’s lab in the Laboratory of Tree-Ring Research, we use long-lived geoduck clams as records of past climate the northeast Pacific. We measure annual ring width, which is strongly and positively correlated to water temperature. Using live and dead shells collected from the ocean floor, we hope to develop a continuous 1,000-year record. Over the summer, I have worked to process, measure, and date the geoduck samples.

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Putting apical media on MTEC cells at an air-liquid interface to conduct TEER measurements.

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Evangelia Sai Pen- Investigating Estrogen-Associated Asthma in Menopausal Women

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Evangelia Sai Pen- Investigating Estrogen-Associated Asthma in Menopausal Women

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In the Ledford Lab, I investigate how changes in estrogen levels during menopause contribute to the development of adult-onset asthma in women. I utilize normal human bronchial epithelial (NHBEs) and mouse tracheal epithelial cells (MTECs). I manipulate their estrogen levels, extract their RNA, and analyze inflammatory gene expression using real-time PCR (qPCR).

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Romeo James - Investigating the Role of MMS19 and Dietary Iron in Mutation Repair

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Romeo James - Investigating the Role of MMS19 and Dietary Iron in Mutation Repair

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In Dr. Maggert’s lab, my project focuses on MMS19 and dietary iron, examining how they affect DNA replication and repair within the cell. We use fruit flies as a model organism due to their genomic similarities to humans. I perform a Basc test to measure the mutation rate by crossing fruit flies with FM7 chromosomes and analyzing the phenotypic markers. The purpose of this study is to reduce the risk of cancer in humans.

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Running a Gel Electrophoresis to test for successfully combined proteins 

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Zain Ahmed Francis – Development of Biomimetic Microparticles for Mimicking Red Blood Cells Using Mechanical Protein Copolymers

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Zain Ahmed Francis – Development of Biomimetic Microparticles for Mimicking Red Blood Cells Using Mechanical Protein Copolymers

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In Dr. Kim’s lab, we investigate the scientific principles underlying biomimetic microparticles designed to mimic red blood cells (RBCs). The growing social need for artificial RBCs stems from persistent shortages and the logistical challenges associated with donor blood supplies. Artificial RBCs present a promising alternative by offering a stable, long-lasting, and universally compatible blood substitute that can be produced on demand.

In the lab, I focus on creating proteins and studying their self-assembly behavior to create defect-free, mechanically robust, and stretchable protein networks. I produce these proteins by inserting target DNA sequences into E. coli, optimizing key parameters to achieve stable, high-yield production. These proteins are then utilized to create defect-free, highly stretchable protein fibers. The outcomes of this research will serve as an important milestone in advancing biomimetic microparticles that effectively emulate the unique mechanical properties of RBCs.

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Performing restraint stress priming on mice before exposing them to a subthreshold dose of umbellulone.

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Maximus Luevanos - Analysis of Migraine-related behaviors in mice using Inflammatory Mediators, Restraint Stress, and Umbellulone.

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Maximus Luevanos - Analysis of Migraine-related behaviors in mice using Inflammatory Mediators, Restraint Stress, and Umbellulone.

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In the Porreca lab, I investigate how two distinct migraine models affect non-evoked migraine-related behaviors in mice. These models include (1) injection of inflammatory mediators onto the dura mater (supradural injections) and (2) restraint stress priming followed by inhalation of a subthreshold dose of umbellulone, a TRPA1 agonist known to trigger migraines in patients with secondary headache disorders. My focus is on evaluating behavioral correlates of migraine, particularly light sensitivity (photophobia) and spontaneous headache-like pain, potentially linked to changes in intracranial pressure (reduction of rearing behavior). Over the summer and into the next semester, I will use these models to assess the efficacy of novel anti-migraine antibody treatments

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Shraddha is practicing aligning the Theta Burst Stimulation coil above the hippocampal target region of lab member, Lisbeth Haaheim.  

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Shraddha Dwivedi - Exploring the Effects of Transcranial Magnetic Stimulation Upon Memory and Cognitive Function in Pre-Alzheimer's and Mild Cognitive Impairment 

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Shraddha Dwivedi - Exploring the Effects of Transcranial Magnetic Stimulation Upon Memory and Cognitive Function in Pre-Alzheimer's and Mild Cognitive Impairment 

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In Dr. Ying-hui Chou’s lab, I am exploring the effects of repetitive trans-cranial magnetic stimulation (TMS) upon neuroplasticity in the hippocampus of patients with Mild Cognitive Impairment (MCI). TMS is a noninvasive form of brain rehabilitation, emitting magnetic pulses to induce electrical activity of neurons within the brain. We perform TMS over multiple days to ensure optimal stimulation, and we measure its effects on plasticity, cognitive function, and brain connectivity through neuropsychological assessments and cognitive not only in the short-term but also in the long-term, much after stimulation occurs. This technique is especially useful in patients with neurological deficits, like pre-Alzheimer’s and MCI patients who experience memory loss due to the degeneration of neurons in a brain region involved in long-term memory storage called the hippocampus. My work specifically investigates how to optimize TMS protocol in the form of accelerated TMS (aTMS) to ensure the most effective impacts on neuroplasticity and memory function. Additionally, I assist in collecting data for a project investigating the potential for transcutaneous auricular vagus nerve stimulation (taVNS) to act as a primer for enhancing the effects of TMS.

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Adding media to small intestine organoids

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Harrison Byrnes - Identifying the cellular contributor of the pattern recognition receptor AIM2 and its role in intestinal development

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Harrison Byrnes - Identifying the cellular contributor of the pattern recognition receptor AIM2 and its role in intestinal development

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AIM2 is a protein canonically responsible for sensing double stranded DNA and driving inflammatory responses to clear pathogens and repair the epithelial lining of the gut. In previous studies, our lab has found that AIM2 promotes the expression of tuft cells which are important for regulating the immune response in conditions like inflammatory bowel disease. My work focuses on determining which cell type contributes AIM2 in the epithelium to drive tuft cell proliferation in order to further understand the mechanism of inflammatory diseases and how certain regulatory components like tuft cells may decrease injury.

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Rylee Freudenthal - Identifying the Signaling Pathways of Opioids and their Effect on Pain Relief  

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Rylee Freudenthal - Identifying the Signaling Pathways of Opioids and their Effect on Pain Relief  

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In Dr. Streicher’s lab we are focused on finding safer ways to treat chronic pain by studying how opioid painkillers work in the body. People with chronic pain are especially vulnerable to the side effects of opioids, including addiction. We are working to understand the specific proteins and signaling pathways that opioids use to relieve pain and cause side effects. By identifying these pathways, we hope to design better drugs that are just as effective at reducing pain but much safer for long-term use. One promising approach we are currently researching is combining opioids with other compounds, such as the natural compound β-caryophyllene (BCP), a type of terpene, which may boost pain relief while allowing for lower opioid doses. This could lead to safer and more effective treatments for people in pain.

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Olanma Ogbonnaya- Neural Mechanisms of Anxiety and PTSD

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Olanma Ogbonnaya- Neural Mechanisms of Anxiety and PTSD

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In the Halladay Lab, I am investigating the neural circuitry behind  fear learning, with a specific focus on the extended amygdala. My project examines how projections from the bed nucleus of the stria terminalis (BNST) contribute to the expression of conditioned fear responses. We are conducting this research using tools like fiber photometry and microscopic imaging. This research provides insights of the neural mechanisms of fear and anxiety and may assist with discovering the neural mechanisms underlying anxiety and PTSD.

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Using R to perform Chi squared tests on virulence factors and disease outcomes.

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Erick Yoakum - Virulence factors of Helicobacter pylori infection impacts on gastric disease outcomes in Native Americans in Northern Arizona

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Erick Yoakum - Virulence factors of Helicobacter pylori infection impacts on gastric disease outcomes in Native Americans in Northern Arizona

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In Dr. Heidi Brown's PEST (Predicting Epidemics in Space and Time), we are working to understand the higher incidence and mortality rates due to gastric cancer among Native Americans. My role is analyzing endoscopy data to look for correlations between genetic traits of gastric bacteria H. pylori and worse outcomes of gastric diseases in patients. We want to see if these higher incidences and mortality rates could be associated with more virulent strains of the bacteria.

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Checking cells on day 8 of transfections (mutating cells)

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Jocelyn Rodriguez - Investigating CDK1 Phosphorylation of CP110 as a Trigger for Pre-Procentriole Formation in Drosophila

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Jocelyn Rodriguez - Investigating CDK1 Phosphorylation of CP110 as a Trigger for Pre-Procentriole Formation in Drosophila

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In the Rogers Lab, I am working on a project aiming to discover the trigger of an amorphous spot into a pre-procentriole required for centriole duplication. The centrosome is the primary microtubule-organizing center in cells. Each centrosome has 2 centrioles; The mother centriole produces an amorphous molecular spot, which then develops into a pre-procentriole, which in turn forms the daughter centriole. Correct centriole duplication is essential to the cell cycle, and its absence can lead to abnormal mitosis and chromosomal instability, an indicator of cancer. We have seen evidence that cyclin-dependent kinase 1(CDK1) phosphorylates CP110, a protein that regulates centriole growth, to promote centriole duplication. We have identified 12 CDK1 motifs in CP110, and I am currently mutating these sites in Drosophila S2 cells to generate phosphonull and phosphomimetic mutants. This will help us discover whether phosphorylation of CP110 is required to transition the spot into the pre-procentriole.

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Abnormal linkage disequilibrium mappings of a putative self-fertilizing marginal population.

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Abby Pearse - Genomic analyses of outcrossing and putative self-fertilizing populations of Yellowstar thistle (Centaurea solstitialis)

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Abby Pearse - Genomic analyses of outcrossing and putative self-fertilizing populations of Yellowstar thistle (Centaurea solstitialis)

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Yellowstar thistle (Centaurea solstitialis), a highly invasive plant species found throughout California, is a particularly interesting “success” story. Unlike most invasive plants, Yellowstar thistle is an outcrossing species; however, marginal populations of Yellowstar thistle have been observed to be allegedly self-fertilizing. My research with Dr. Katrina Dlugosch focuses on comparing population genomics, such as nucleotide diversity and coefficients of inbreeding, of outcrossing and allegedly ‘selfing’ populations to isolate any loci, genes, or nucleotide sequences that may be contributing to the differences in reproductive mechanisms.

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Collecting samples from Franz Diffusion Cells

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Angel Marquez - Comparative Analysis of Polymers for Microneedle-Based Transdermal Drug Delivery

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Angel Marquez - Comparative Analysis of Polymers for Microneedle-Based Transdermal Drug Delivery

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In the Drug Preformulation, Repurposing and Delivery (D-PReD) Research Lab, I work with various drugs to test their performance with transdermal drug delivery via Microneedle applications. Microneedles are fairly new in the pharmaceutical industry and have potential to administer drugs in a less invasive manner through the skin. I experiment with various polymers to test which ones provide the best drug retention. We test this using pig skin and see how much of the drug is retained at multiple time points. I will eventually start my own independent project where I use micro needles for cosmetic purposes, testing phenols for anti-aging properties.

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Jeremy Purdy - Evaluating Dietary Recall Data for Predicting Warfarin Dose Variability

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Jeremy Purdy - Evaluating Dietary Recall Data for Predicting Warfarin Dose Variability

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In the Karnes Lab, I’ve been working on a project exploring how a patient’s diet impacts their Warfarin dose. Warfarin is a commonly prescribed blood thinner used to prevent blood clots. However, prescribing the correct dose to a patient can be challenging. Side effects are common, especially in minority groups (who are underrepresented in dosing algorithms).

In particular, we’re interested in vitamin K, which plays a role in activating clotting factors and may influence how much Warfarin a patient needs. My role has focused on applying computer science skills to help clean, organize, analyze, and visualize survey data related to patient diet and Warfarin dosage.

I've met cool people, learned new skills, and have been enjoying the experience :)

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Running a behavioral experiment using the 3D radial arm maze

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Sawyer Sullivan - Examining the Neurological Basis of Behavior Following Events of Early Life Stress

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Sawyer Sullivan - Examining the Neurological Basis of Behavior Following Events of Early Life Stress

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In the Halladay Lab, I am investigating the effects of early life stress on the brain and behavior, using mice to look at social motivation and neural and behavioral responsiveness to stressors. I am exploring the inter- and transgenerational inheritance of behavioral alterations and genetic changes due to maternal or paternal stress. Using techniques such as behavioral assays, immunohistochemistry, and fiber photometry to examine specific regions of the brain, I aim to fill gaps in existing research surrounding the neurological and behavioral differences of abuse vs. neglect in early childhood.

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Spike-sorting electrophysiology data with my assistant

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Kabir Rathore Muthu- Neural Circuitry Underlying Social Behavior in Mice Exposed to Early Life Stress

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Kabir Rathore Muthu- Neural Circuitry Underlying Social Behavior in Mice Exposed to Early Life Stress

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In the Halladay lab, we study how early life stress (ELS) disrupts brain development, behavior, and learning in manners that may contribute to mental disorders. I am working on a project that seeks to determine the impact ELS has on social behavior, including maternal care and social interaction-based reward and anxiety. Using a combination of neural recordings through electrophysiology, selective manipulation of neuronal activity using optogenetics, behavioral testing, imaging, and other techniques, we aim to link the behavioral and psychological changes caused by ELS to its neural underpinnings, potentially opening up new avenues of treatment for those afflicted with early-life trauma.

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Gwen Flores: Physio-chemical And Biological Processes Affecting Biosorption of Metals with Fungi for Bioremediation

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Gwen Flores: Physio-chemical And Biological Processes Affecting Biosorption of Metals with Fungi for Bioremediation

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The Nihi Lab conducts critical biogeochemical research aimed at pioneering accessible, low-cost biopolymers for small-scale water and soil remediation in response to communities facing contamination caused by abandoned and active mines. Dr. De Vore has devoted over 10 years to this research and curated a lab community with a shared passion to make a difference in rural communities. We have cultured Fusarium and Talaromyces sp. this summer and are processing aqueous chemistry samples using ion chromatography and other instruments.

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Ruhi Painaik - Investigating the role of TgBCP1 in the encystment of Toxoplasma gondii

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Ruhi Painaik - Investigating the role of TgBCP1 in the encystment of Toxoplasma gondii

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Toxoplasma gondii is an intracellular parasite that chronically and asymptomatically infects up to a third of the world’s population by changing from a fast-replicating form to a slow-replicating and encysting form. In the immunocompromised, the encysting form can cause severe disease by reverting to the fast-growing form. However, no therapies effectively treat the encysting form. To identify new therapeutic targets, we need a deep understanding of the encysting form of Toxoplasma. To accomplish this goal, the Koshy Lab seeks to define how a previously identified Toxoplasma gene (Brain Colonization Protein 1 or TgBCP1) affects parasite encystment. TgBCP1 is known to have two variants. As a prior student generated a Toxoplasma strain that lacks TgBCP1, I am currently working on adding back (or complementing) the knockout strain with different forms of TgBCP1. With the knockout and complemented strains, we can further decipher how TgBCP1 influences chronic infection.

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Katelyn Cannon banding Western bluebird nestlings

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Katelyn Cannon- Compiling a Developmental Brain Atlas of a Wild Songbird

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Katelyn Cannon- Compiling a Developmental Brain Atlas of a Wild Songbird

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In the Duckworth lab I am working to create an atlas tracking brain development in a wild songbird. The completed atlas can be used in future studies to guide the lab's research on western bluebirds, and also as a resource for comparative neuroanatomy. This summer I am collecting eggs at different stages and staging the embryos. In the fall I will cryosection and stain these to compile into the finished atlas.

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Shalan Wu - Characterization of Fungal ERG7 Inhibitors

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Shalan Wu - Characterization of Fungal ERG7 Inhibitors

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In Dr. Hongmin Li’s lab, I am working to understand how various inhibitors affect the activity of lanosterol synthase – a protein encoded by the ERG7 gene in fungi and hLSS gene in humans. After purifying the membrane protein, we will use antifungal enzyme activity assays to measure and compare the efficacy of each inhibitor. Inhibiting lanosterol synthase in fungi blocks the ergosterol biosynthesis pathway, leading to the accumulation of toxic precursors upstream of lanosterol. This buildup disrupts cellular function and ultimately causes cell death. Because fungi are increasingly developing resistance to existing drugs like azoles, we hope to identify novel antifungal inhibitors to combat diseases caused by fungi such as yeast infections or cryptococcal meningitis.

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Standardizing collected full text data for later analysis.

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Natalia Grazda-Valdez - Understanding the role of wild suids in Mycobacterium bovis transmission in Multi-host systems

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Natalia Grazda-Valdez - Understanding the role of wild suids in Mycobacterium bovis transmission in Multi-host systems

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In the Salvador lab, we are conducting a systematic review to better understand the role of wile suids in Mycobacterium bovis transmission, which is the main cause of animal tuberculosis in livestock and wildlife, and can cause zoonotic tuberculosis in humans. The issue surrounding M. bovis lies with spread and control of animal tuberculosis at the wildlife, livestock, and human interface, presenting a global economic and public health challenge for humans and animals alike. Maintenance hosts sustain the pathogen in an area without requiring reintroductions from other species. Wild suids (i.e., wild boar [Sus scrofa]) serve as maintenance hosts for M. bovis in several regions. A thorough understanding of the factors that promote maintenance host status is necessary to better improve disease control.

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Connor Carney - Understanding the Evolution of Segmentation using Tribolium castaneum

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Connor Carney - Understanding the Evolution of Segmentation using Tribolium castaneum

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Segmentation is the division of an organism's body plan into repeated parts, and that body plan is determined during early development. Many different organisms undergo segmentation during early development, including us, though some organisms have different processes for segmentation. For example, Drosophila melanogaster (the fruit fly) develops its segments nearly simultaneously during development. This species is relatively young in evolutionary terms compared to other species, such as Tribolium castaneum (red flour beetle). Tribolium adds its segments sequentially in a clock-like fashion, begging the question of how the “all at once” process of segmentation evolved in the fruit fly? In Dr. Nagy's lab, we are currently researching the components of a molecular oscillator in the red flour beetle, which we believe is responsible for driving its sequential segmentation. This oscillator works through multiple genes being turned on and off by each other, ultimately allowing segments to be made one at a time. Our current gene of focus involved in the oscillator is even-skipped (eve), a pair-rule gene that, when knocked out, prevents segmentation from occurring. For this gene, we are utilizing the CRISPR-Cas9 system to knock-out its enhancer regions, which are responsible for regulating the spatio-temporal expression of even-skipped, and are crucial for understanding the patterns for how this gene functions.

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Vijetha Logaprabhu - Examining the neuronal damage to the retina as a result of diabetes. 

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Vijetha Logaprabhu - Examining the neuronal damage to the retina as a result of diabetes. 

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In the Eggers Lab, under the guidance of  Dr. Erika Eggers and Ms. Andrea Wellington, I have been working on diabetic retinopathy investigating the neuronal damage in the retina specifically in the inner nuclear layer containing the GABAergic amacrine cells and the ganglion cell layer housing the alpha ganglion cells. Diabetes is a chronic disease in which either the pancreas does not produce enough insulin or the body cannot effectively use the insulin it produces. As a result, the human body becomes hyperglycemic due to the circulation of high glucose in the bloodstream. A major complication that accompanies diabetes is diabetic retinopathy. Diabetic retinopathy involves damage to blood vessels and neurons in the tissue at the back of the eye - retina, which leads to vision loss. While there has been previous research studies on the effect of diabetes on the retina blood vessel damage, there has been less research on the neuronal aspect. Thus our lab focuses on identifying the neuronal damage resulting from diabetes. In addition to this, I have dissected retinas from the mouse eyes for immunostaining with antibodies labeling for activated microglia to analyze whether the percent of activation of microglia is different between the retinas of diabetic and non-diabetic mice.

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Inspecting a plate of Arabidopsis thaliana to extract DNA from for genotyping.

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Genevieve Quezada: Exploring the Role of Mechanosensitive Ion Channels in Plant Stress Signaling

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Genevieve Quezada: Exploring the Role of Mechanosensitive Ion Channels in Plant Stress Signaling

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In the Woodson Lab, I study how plants respond to heat and wounding by investigating their stress signaling systems, specifically mechanosensitive ion channels (MSLs). Through this research, I am exploring how plant research supports long term goals like climate resilience and improving crop nutrition. Working with Arabidopsis mutants and using techniques like genotyping, qPCR, and cloning has helped me build core molecular biology skills and grow confidence as a developing researcher.

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Aristotle Ronyak - Analysis of general research data

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Aristotle Ronyak - Analysis of general research data

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I am using the R and Python coding languages to analyze research findings and transcribe them into a more readable and conclusive format. This is an important aspect for the success of research, as it needs to be understood and presentable. The results of any research study are useless without the ability to draw conclusions from them, and being able to present the results to a broader audience is needed for them to be impactful.

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Adding HTRF-based detection antibodies to MOR-CHO cells after 30 min NCWR-compound treatment, finalizing cAMP accumulation assay.

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Josue Sarmiento - Screening noble compounds as candidates for opioid abuse therapeutics. 

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Josue Sarmiento - Screening noble compounds as candidates for opioid abuse therapeutics. 

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I work for Dr. Frank Porreca, under the mentorship of Dr. Justin LaVigne. I have been working for Dr. LaVigne and his collaboration with the National Center for Wellness and Recovery (NCWR), involving treatments for Opioid Use Disorder (OUD). The project involves developing an ultra-potent antagonist of the mu opioid receptor (MOR) for treating opioid overdose. Fentanyl, and other opioids, bind to the MOR to produce clinically relevant effects such as analgesia, but also to produce possibly lethal effects such as respiratory depression and addiction. My role in this endeavor is helping characterize the pharmacological activity of these compounds in vitro through running plate-based cell signaling assays, such as cAMP accumulation. These assays help inform our medicinal chemists on what chemical modifications change the activity of the compound. Through iterate rounds of in vitro characterization and medicinal chemistry, we hope to produce a unique candidate to push into clinical development for us in combating opioid overdose.

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Examining protein expression through IHC

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Kanishk Dravid Anmala - Investigating the Effects of Early Life Stress on Behavior and Neural Circuits in Mice 

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Kanishk Dravid Anmala - Investigating the Effects of Early Life Stress on Behavior and Neural Circuits in Mice 

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At the Halladay Lab, we study how early life stress (ELS) impacts social behavior, fear learning, and neural circuitry in the brain (such as the VTA, PVN, and BNST). My research primarily focuses on how ELS (modeled through maternal separation and early weaning) affects social behavior and reward-seeking in mice.

We assess behavior using operant chambers and mazes, and examine neural changes through vibratome sectioning, imaging, immunohistochemistry, and retrograde tracing. By delving into both behavior and neural circuitry, our goal is to better understand the mechanisms by which ELS contributes to mental disorders such as PTSD.

In the future, our research can contribute to the development of targeted treatments and cures for individuals affected by early life adversity.

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Kusuma Teluguntla - Age dependance of whole-brain structural connectivity studied via diffusion MRI

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Kusuma Teluguntla - Age dependance of whole-brain structural connectivity studied via diffusion MRI

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In the Trouard lab, I am analyzing MRI images to try to better understand how people can maintain their cognitive health as they grow old. Specifically, I am working with diffusion-weighted MRI, which is used to measure small, three-dimensional movements of water in the brain, which can map out the pathways of myelinated neurons in the brain's white matter.  Mapping these pathways is done through a mathematical process called "tractography." From the whole-brain "tractograms" created, we can calculate "connectomes" that quantify the structural connectivity of individual gray matter regions of the brain with all other regions.  After creating tractograms and connectomes for all of the subjects enrolled in a Precision Aging Network study, I will determine if the MRI data can predict whether subjects are aging in a healthy manner. This can aid in understanding and diagnosing neurodegenerative disorders like Alzheimer's and Parkinson's disease early on, while treatment or prevention strategies are available, before they can fully onset and impact a person's cognitive abilities and independence.

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Daniel Rivera Castelo - The Effects of Prompt Variation on Large Language Models for Medical Question Answering

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Daniel Rivera Castelo - The Effects of Prompt Variation on Large Language Models for Medical Question Answering

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In Dr. Steven Bethard's lab, my project is focused on seeing how AI models can be used to answer medical questions. It investigates how different ways of giving AI models information can make a difference in the accuracy of the answer an AI model gives back.

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Observing the health and growth of two of our genetically modified plants. Arabidopsis thaliana is the model plant species used for our experiments. 

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Victoria Anne Inlow - Elucidating and Engineering the CEPR1 Nitrogen Signaling Pathway

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Victoria Anne Inlow - Elucidating and Engineering the CEPR1 Nitrogen Signaling Pathway

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I am working on a project in the Beilstein Lab that aims to expand our understanding of how plants perceive and internally communicate nitrogen availability in the soil. This research has the potential to inform future agricultural practices by significantly reducing the need for nitrogen fertilizer application on crops.

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Andrew Kim - Deducing the effects of mutations in cardiac TnT linker region (R173W-cTnT and Delta 160E) and tropomyosin (D219N-Tm) on myofibril kinetics. 

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Andrew Kim - Deducing the effects of mutations in cardiac TnT linker region (R173W-cTnT and Delta 160E) and tropomyosin (D219N-Tm) on myofibril kinetics. 

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The Tardiff laboratory's research focuses on the molecular mechanisms that underlie genetic cardiomyopathies caused by point-mutations in the cardiac thin filament. In previous structural studies, the flexible linker region has been shown to play a critical role in actomyosin interactions and cardiac contractility. However, FRET-based analysis has shown that mutations such as Delta 160E reposition the flexible linker and cardiac impair contractility. To further explore the functional effects of mutations within this region, I have been conducting myofibril ATPase experiments to measure myofibril kinetics on the mutations, Delta 160E and R173W-cTnT. Additionally, because the Tardiff lab has focuses in small molecule interventions to improve disease management, my other projects involve working with mutations in tropomyosin (D230N-Tm and D219N-Tm). The goal is to determine a baseline myofibril kinetic analysis and then test the drug with the mutations to deduce the efficacy of the small molecule inhibitor, Z06.

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CYP19A1 is a gene that creates aromatase, an enzyme essential for producing estrogens. Estrogens play a fundamental role in processes such as cell cycle progression and cellular proliferation. Interestingly, macrophages also express the CYP19A1 gene, enabling them to produce local estrogen. However, the specific role of this estrogen production in macrophages remains unclear.  In Dr. Xinxin lab, I am studying how the deletion of CYP19A1 in macrophages affects lung tissue healing in mice. Before I joined the project, the lab had already removed the gene in these immune cells and RNA sequencing to observe how other genes responded. I’m now analyzing this dataset using R programming and bioinformatics methods to identify genes that may be involved in disrupted tissue repair, inflammation, or cancer development.

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Estrogen Synthesis by Macrophages Is Critical for Lung Repair: Transcriptomic Analysis Following Cyp19a1 Deletion

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Estrogen Synthesis by Macrophages Is Critical for Lung Repair: Transcriptomic Analysis Following Cyp19a1 Deletion

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Preparing brain tissue slides utilizing immunohistochemistry technique to visualize neural activation patterns

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Alan Andrade - Social Behavior Encoding in Neural Circuits Following Early Life Adversity

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Alan Andrade - Social Behavior Encoding in Neural Circuits Following Early Life Adversity

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I study how early life stress, such as maternal separation, alters neural circuits involved in social behavior. In the Halladay Lab, we use mice models to investigate specific pathways in the BNST as well as other regions of the brain that regulate anxiety and reward. I uncover how stress shapes brain development and behavior, and by identifying the circuit mechanisms underlying social deficits, we aim to inform future treatments that improve emotional resilience, social function, and ultimately overall well-being.

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Sedona O'Hearn - Data Analysis on Maternal Physiological Changes During Exclusive Breastfeeding

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Sedona O'Hearn - Data Analysis on Maternal Physiological Changes During Exclusive Breastfeeding

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Dr. Erickson’s MuMH Lab researches different aspects of pregnancy, childbirth, and postpartum. Much of what is known about the body during pregnancy and postpartum comes from scheduled appointments in which information is collected periodically. But the day to day fluctuations of physiological factors such as heart rate or temperature that a mother might experience is not as well documented. With the recent rise of wearable technology allowing for more continuous monitoring, more studies have been conducted exploring this side of the motherhood experience. One area of interest is understanding the effects exclusive breastfeeding has on a mother. Research has found that it’s not just the infant who is impacted by longer periods of exclusive breastfeeding, but the mother as well, with studies linking it to benefits like lower blood pressure and hormonal regulation. MuMH Lab’s BioBAYB Project used Oura rings to collect continuous information on mothers during pregnancy through 6 months postpartum. I’m currently exploring and analyzing this data in R in the hopes of better understanding the impact exclusive breastfeeding might have on a mother’s body.

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Chris Wilds - Using High Content Screening Technology to Investigate Mechanisms of Lifespan Extension in C. Elegans

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Chris Wilds - Using High Content Screening Technology to Investigate Mechanisms of Lifespan Extension in C. Elegans

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In the Sutphin lab, we use high-content, long-term screening technology to monitor thousands of C. elegans at once and identify genetic and environmental factors that influence aging. I knock down genes with RNAi and use the “WorMotel” system to observe the effects on worm aging. Currently, I’m focusing on how various genes may interact with two lifespan-extending compounds we study, 3-HAA and cholesterol, to reveal the exact mechanisms behind lifespan extension and inform therapies for age-related disease.

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Record and placing back processed urine samples collected from partnered fire departments across the nation.

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Braddock Ghahate - Fire Fighter Cancer Cohort Study

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Braddock Ghahate - Fire Fighter Cancer Cohort Study

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Under Dr Burgess' lab, Fire Fighter Cancer Cohort Study (FFCCS), we aim to understand the health impacts within the fire service and prevent associated risks to cancer. To tackle this mission, we collect a series of survey, exposure, and biological data nationwide to process and assess occupational risk factors to cancer. I am tasked to analyze survey data of women's gear fitting feedback and comparing them to men's data. We believe the historically male-predominant occupation has bled into the ergonomic models in gear and equipment for women fire service members, potentially hindering protection from environmental exposures.

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In this image, I am performing an antimicrobial resistance assay to test how encoding a capsule affects survival against host defense proteins. 

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Akshay Menghani - The Role of the Polysaccharide Capsule in Commensal Neisseria.

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Akshay Menghani - The Role of the Polysaccharide Capsule in Commensal Neisseria.

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The Neisseria genus consists of a diverse group of species commonly found in the oral cavity and pharynx of their hosts. My research focuses on how noninfectious Neisseria species utilize a polysaccharide capsule to support survival and persistence within the host environment.

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The Mel & Enid Zuckerman College of Public Health provides a Mobile Health Unit (MHU) that provides medical services for marginalized communities around Tucson. 

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Arturo Tovar Jr. - Reviewing Mobile Health Unit Delivered HPV Self-Collection within the community of Tucson

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Arturo Tovar Jr. - Reviewing Mobile Health Unit Delivered HPV Self-Collection within the community of Tucson

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Despite being highly preventable with screening and HPV vaccination, cervical cancer persists as one of the most common forms of cancer women contract in the United States, and women who come from low income, uninsured, and even ethnic backgrounds are typically less likely to be up-to-date on cervical cancer screening. In Dr. Morenz’s lab, we are distributing surveys to women of underserved communities here in Tucson to collect responses regarding preferences for HPV self-collection distributed via mobile health unit. A primary concern when it comes to the discussion of mobile health services as well as HPV collection is availability, and with our study we hope to gain an insight into the concerns that surround both issues and use that information to standardize HPV self-collection and screening as a whole.

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Imaging mixtures with resultant structures using the confocal fluorescence microscope

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Laura Serikova - Analyzing self-assembly patterns formed through synthetic cell-cell adhesion in E. coli

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Laura Serikova - Analyzing self-assembly patterns formed through synthetic cell-cell adhesion in E. coli

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As a member of the Riedel-Kruse lab, I study synthetic multicellular assemblies in E. coli. Our lab developed the first synthetic cell-to-cell adhesion toolbox, opening up a new area of research on the emergence of multicellularity and colloidal self-assembly. Together with my mentor, Ph.D. student Kira Hallerbach, I analyze aggregate formation caused by membrane-displayed nanobody-antigen pairs. This formation is mediated by surface-expressed nanobody-antigen pairs and controlled by specific mixture parameters, including cell form factor, adhesin type, cell-to-cell ratios, and cell density. Specifically, I prepare cell cultures and use a fluorescent microscope to image and collect data on the resultant structures that form in these mixtures. Our goal is to understand the types of structures that can form with these adhesins and the extent of our control over the patterning and morphology of these structures.

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Mia Sponseller - Investigating Strategy Differences Between Young and Old Rats in the Morris Water Maze Task

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Mia Sponseller - Investigating Strategy Differences Between Young and Old Rats in the Morris Water Maze Task

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In the Barnes Lab, we investigate the role of prefrontal cortex-hippocampus interactions in age-related deficits in spatial working memory.  The goal is to see what memory deficits are normal with aging, versus which are pathological.  Using the Morris watermaze, a spatial memory task, we are able to compare the performance of young and aged rats.  Using a package in R called Rtrack, we can analyze whether young and old rats use different approaches to solve the task.  Characterizing which strategy types are predominantly used by young and aged rats may help us identify what brain circuits are being used to solve the navigation task, and how that may change with age.

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Jean Carlo Marca - Unravelling How Pain Disrupts Sleep Through Calca Neuron Activity

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Jean Carlo Marca - Unravelling How Pain Disrupts Sleep Through Calca Neuron Activity

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In Dr. Porreca’s lab at the Department of Pharmacology, I have been studying how pain affects sleep in mice. Specifically, in my UBRP project, I have been investigating

whether parabrachial Calca neurons that drive pain also disrupt sleep in mice. Calca

neurons are cells that express the Calca gene, which encodes calcitonin gene-related peptide (CGRP), one of the most relevant peptides involved in migraine

pathophysiology. Using electroencephalogram (EEG) and electromyogram (EMG) recordings, I track changes in brain activity to define sleep-wake stages and understand how pain interferes with sleep, reflecting what occurs in human patients. Understanding

and addressing this complex interplay may allow the development of therapeutic

strategies to improve sleep quality and enhance pain management.

Being part of this research project has been a truly rewarding experience. As someone passionate about medicine, working on this project has provided me with extensive knowledge in the areas of pain and sleep, along with valuable experience in preclinical research. It has further deepened my interest in neuroscience and the clinical

applications of sleep and pain research. This experience has helped me realize that I want to pursue a medical career grounded in research. I am very grateful for the financial support that has allowed me to fully dedicate myself to this work and grow both professionally and academically.

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Analyzing data from scientific literature on uranium contamination in groundwater and performing a detailed risk assessment.

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Dawnae Yazzie-Testing Water for Uranium in Native Communities

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Dawnae Yazzie-Testing Water for Uranium in Native Communities

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My research evaluates the health risks associated with uranium-contaminated groundwater in the Becenti Chapter by conducting a thorough literature review and comparing scientific findings to EPA safety standards. As a member of Dr. Hoover’s lab and under the mentorship of Chrisa Whitmore, I analyze existing data better to understand potential long-term exposure impacts on community health. Through this work, I strive to raise awareness about uranium contamination, promote safer water practices, and actively engage with the community to help them understand these exposure risks. Ultimately, this research supports efforts to protect both current and future generations within Native communities who are disproportionately affected by environmental contamination.

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Dae-Kyung Kim - Testing combinational therapies on Merkel Cell Carcinoma (MCC) cell lines

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Dae-Kyung Kim - Testing combinational therapies on Merkel Cell Carcinoma (MCC) cell lines

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In Dr. Padi's lab in Life Sciences South (LSS), we are testing different silencing protocols in certain genes to observe the effect on the transcriptional and translational landscape. My project is focused on discovering novel treatment options that are complementary to immunotherapy for MCC patients. Although immunotherapy has helped a lot of patients, we only see about 50% of patients responding to the therapy, leaving the rest of the patients with no real options. Our lab is focused on understanding the different factors that affect tumorigenesis as well as stemness of MCC to find a potential target for therapy. In the lab, I run protocols like qPCR, western blots, and immunofluorescence to confirm the findings in past scientific literatures and computational screening models!

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Anna Campbell: Targeting mosquito larvae midguts with chemical probes

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Anna Campbell: Targeting mosquito larvae midguts with chemical probes

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In the Jewett lab, we develop molecular probes to selectively target mosquito midgut proteins. These probes are fine-tuned to react in the exceptionally alkaline larval midgut and also allow for additional functionalization. As mosquito larvae are aquatic, the probes should also be water soluble. Using standard organic synthesis techniques, I’m investigating whether a polyethylene glycol linker component would withstand mosquito larvae gut conditions to improve the probes’ solubility while maintaining customizability.

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Inspecting my stock and virgin fruit fly vials for later use.

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Zachary Boydell - Understanding Wrapping Glia's Supportive Role in Proper Axon Function and Development

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Zachary Boydell - Understanding Wrapping Glia's Supportive Role in Proper Axon Function and Development

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Glia are supportive cells found throughout our nervous system that are critical to proper neuron function and development. In Dr. Corty's lab, we study the interrelationship between wrapping glia and axon function and development. We do this by using genetic manipulation techniques such as knockdown in our fruit fly model organism. This knowledge of how glia wrap neurons may allow us to better take action in the case of nerve or brain injuries or diseases.

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Imaging larvae dissections on our spinning disc confocal microscope to analyze axon health in relation to wrapping glia. 

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Ellie Schrock- Understanding the Dynamics Between Wrapping Glia and Axons in the Peripheral Nervous System 

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Ellie Schrock- Understanding the Dynamics Between Wrapping Glia and Axons in the Peripheral Nervous System 

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In the Corty lab, I study axon-related glia in the peripheral nervous system of fruit flies. Our lab aims to understand how and why glia wrap axons. Glia are important to study because they increase the speed of communication between neurons, are crucial for keeping axons healthy, and are involved in responses to injury. When glia do not wrap axons properly, it leads to neuronal loss.
We use genetic manipulation tools to knock down specific genes in glial cells to study how it affects axon survival. We hope to identify important genes that allow glia to properly support, protect, and provide nourishment to neurons.

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Using databases Embase and PubMed to screen through articles.

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Noah Henio-Analyzing Interventions Addressing Indoor Air Quality in Indigenous Settings

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Noah Henio-Analyzing Interventions Addressing Indoor Air Quality in Indigenous Settings

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My research focuses on understanding how indoor air quality is being improved in Indigenous communities. Specifically, I'm conducting a scoping review to identify the types of interventions used such as mold remediation, improved ventilation, or asthma education and how they are implemented. Here, I am screening research articles, a key step in the review process where I carefully read through each study to determine if it meets the inclusion criteria for my project. This is meaningful work because clean indoor air is a key aspect of respiratory health and overall wellness, and it supports long term, community based solutions that promote health equity and resilience in Indigenous communities.