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In 1796, Edward Jenner inoculated a 13-year-old boy with the vaccine virus and demonstrated immunity to smallpox.
In 1798, the first official smallpox vaccine was made.
Smallpox has a 30% fatality rate and this disease fully destroyed the Aztec empire by itself.

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The early Tetanus vaccine first started to be used in the early 1920s.
This ended up leading to the development of the tetanus toxoid in 1924, which was widely used in WWII.
Now almost everyone gets a tetanus shot every 5 years to protect themselves from the infection.
Tetanus has a 20% fatality rate and kills over 293,000 globally a year.

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In 1942, A vaccine that includes both influenza A and B viruses is created after the discovery of influenza B viruses.
In 1945, the first Flu A vaccine is licensed for use in the US.
The flu kills an average of 389,000 people annually and costs the US economy an average of $5.8 billion a year.

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In the early 1950s, the first successful vaccine was made by US physician Jonas Salk the first test was on himself and later it was used on 1.6 million children in Canada, Finland and the US.
Polio kills 5% of children that contract it and around 30% of adults.

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The main COVID-19 vaccination was officially released for use of people aged 16 and older on December 11 2020.
Then early the next year on May 10 is was released for children aged 12-15.
COVID-19 was very dangerous and killed over 4 million people globally from late 2019 - mid 2021.
It also lead to $16 trillion worth of government financial support in the U.S.A.