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Randomized Controlled Trial

doi: 10.3390/nu14030427.

Affiliations

¹ School of Human Movement and Nutrition Sciences, University of Queensland, Brisbane, QLD 4072, Australia.

² RDC Clinical, Newstead, Brisbane, QLD 4005, Australia.

³ Department of Drug and Health Science, University of Catania, Viale A. Doria 6, 95125 Catania, Italy.

Free PMC article

Randomized Controlled Trial

Free PMC article

Affiliations

¹ School of Human Movement and Nutrition Sciences, University of Queensland, Brisbane, QLD 4072, Australia.

² RDC Clinical, Newstead, Brisbane, QLD 4005, Australia.

³ Department of Drug and Health Science, University of Catania, Viale A. Doria 6, 95125 Catania, Italy.

Abstract

This study aimed to assess the efficacy of a blood orange Citrus sinensis standardized extract from "Moro" cultivar, on weight loss in overweight but otherwise healthy individuals. Anthocyanins and particularly cyanidin 3-glucoside, found in a large variety of fruits including Sicilian blood oranges, can help to counteract weight gain and to reduce body fat accumulation through the modulation of antioxidant, anti-inflammatory and metabolic pathways. In this randomized, double blind, placebo-controlled study, all participants (overweight adults aged 20−65 years old) were randomized to receive either Moro blood orange standardized extract or a placebo daily for 6-months. The primary outcome measure was change in body mass and body composition at the end of the study. After 6-months, body mass (4.2% vs. 2.2%, p = 0.015), body mass index (p = 0.019), hip (3.4 cm vs. 2.0 cm, p = 0.049) and waist (3.9 cm vs. 1.7 cm, p = 0.017) circumferences, fat mass (p = 0.012) and fat distribution (visceral and subcutaneous fat p = 0.018 and 0.006, respectively) were all significantly better in the extract supplemented group compared to the placebo (p < 0.05). In addition, all safety markers of liver toxicity were within the normal range throughout the study for both analyzed groups. Concluding, the present study demonstrates that Moro blood orange standardized extract may be a safe and effective option for helping with weight loss when used in conjunction with diet and exercise.

Keywords: BMI; body mass; cyanidin 3-glucoside; fat distribution; flavonoids; physical activity.

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Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

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national center for biotechnology information

# data[].attributes.attachment_link.title
Effectiveness of "Moro" Blood Orange Citrus sinensis Osbeck (Rutaceae) Standardized Extract on Weight Loss in Overweight but Otherwise Healthy Men and Women-A Randomized Double-Blind Placebo-Controlled Study - PubMed

# data[].attributes.attachment_link.description
This study aimed to assess the efficacy of a blood orange Citrus sinensis standardized extract from "Moro" cultivar, on weight loss in overweight but otherwise healthy individuals. Anthocyanins and particularly cyanidin 3-glucoside, found in a large variety of fruits including Sicilian blood oranges ...

# data[].attributes.attachment_link.title
Benefits of Blood Oranges: Can They Help You Lose Weight?

# data[].attributes.attachment_link.description
Citrus fruits are rich in vitamin C and have other health benefits as well. There's one type of citrus fruit, blood oranges, that may even help you shed a few pounds. Find out why.