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DNA
ATG TCTCCTTGTCAA

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DNA Coding strand:
ATG TCT CCT AGT CAA

DNA Template strand:
TAC AGA GGA TCA GTT

mRNA Codons
UAC AGA GGA UCA GUU

tRNA anticodons
AUG UCU CCU AGU CAA

Amino acid sequence

Normal M S P S Q

Mutant M S P C Q

work with the second Serine

Mutant mRNA
UAC AGA GGA ACA GUU

Mutant DNA Coding strand:
ATG TCT CCT TGT CAA

Questions

1. Methionine

2. post translation modification

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This activity on the DNA spiral was adopted by the students and provided fun learning.

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DNA

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It seems so fun to solve. But my students way too little to solve this. I'm gonna show this graphic to them. But like I said it will be difficult for them to solve.

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1.       DNA C   - ATGTCTCCTATGTCAA

2.       DNA T –TACAGAGGATCAGTT

3.       m RNA –AUG  UCU  CCU  AGU  CAA

4.       t RNA    -uac  aga  gga ucc guu

5.       normal  met- ser-pro-ser-gin

6.       mutant  met-cys-pro-ser-gin

7.       mutant Mrna    AUG UGA CCU AGU CCA

8.       mutant DNA  ATG TGT CCT AGT CAA

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DNA C  ( ATGTCTCCTATGTCAA)

DNA T (TACAGAGGATCAGTT)

m RNA (AUGUCUCCUAGUCAA)

t RNA  (UACAGAGGAUCCGUUU)

normal  met- ser-pro-ser-gin

mutant  met-cys-pro-ser-gin

mutant mRNA (AUGUGACCUAGUCCA)

mutant DNA  (ATGTGTCCTAGTCAA)

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The use of DNA code was an enjoyable and challenging activity. we had difficulty reaching the result. but we reached the final result.

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1.       DNA C   - ATGTCTCCTATGTCAA

2.       DNA T –TACAGAGGATCAGTT

3.       m RNA –AUG  UCU  CCU  AGU  CAA

4.       t RNA    -uac  aga  gga ucc guu

5.       normal  met- ser-pro-ser-gin

6.       mutant  met-cys-pro-ser-gin

7.       mutant Mrna    AUG UGA CCU AGU CCA

8.       mutant DNA  ATG TGT CCT AGT CAA

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DNA template strand
TAC AGA GGA TCA GTT
mRNA codon
AUG UCU CCU AGU CAA
tRNA codon
UTC AGA GGA UCA GUU
Amino acid sequence
Normal
Met Ser Pro Ser Gln
Mutant
Met Cys Pro Cys Gln
Mutant mRNA
AUG UGU CCU UGU CAA
Mutant DNA coding strand
ATG TGT CCT AGT CAA

Answers
1. Methionine
2. Probably after the protein is made it is removed from the sequence

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DNAC/ATGTCTCCTATGTCAA

DNAT/TACAGAGGATCAGTT

mRNA/AUGUCUCCUAGUCAA

tRNA/UACAGAGGAUCCGUU

normal  met- ser-pro-ser-gin

mutant  met-cys-pro-ser-gin

mutant mRNA/AUG UGA CCU AGU CCA

mutant DNA/ATG TGT CCT AGT CAA

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DNA coding strand:
ATG TCT CCT AGT CAA
DNA template strand:
TAC AGA GGA TCA GTT
mRNA codons:
AUG UCU CCU AGU CAA
tRNA anticodons:
UAC AGA GGA UCA GAA
AA sequence wt:
Met Ser Pro Ser Gln
AA sequence mut:
Met Cys Pro Ser Gln
Mutant mRNA:
AUG UGU CCU AGU CAA
Mutant DNA cds:
ATG TGT CCT AGT CAA

1 Methionine
2. Because it has been removed after synthesis

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My Activity on the DNA:
1. TACAGAGGATCAGTT
2. AUG UCU CCU AGU CA A
3. UAC AGA GGA UCA GUU
4. S P S Q
5. C P S Q
6. AUG UGU CCU AGU CAA
7. AT GTGTCCTAGTCAA

QUESTIONS
1. MET

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This activity on the DNA spiral was adopted by the students and provided fun learning.

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After a friend with moe knowledge helped me I was ale to figure it out.

DNA Template Strand:
TACAGAGGATCAGTT

mRNA Codons:
AUG;UCU;CCU;AGU;CAA

tRNA Anti codons;
UAC;AGA;GGA;UCA;GUU

Amino Acid Sequence:
Met Ser Pro Ser Gin

Mutated Amino Acid:
Met Cys Pro Ser Gin

Mutated mRNA:
AUG;UGU;CCU;AGU;CAA

Mutant DNA Coding Strand:
ATGTGTCCTAGTCAA

1) Met 2)IT is removed after protien synthesis

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I am with Beatriz, the other primary teachers, and all those whose heads this is waaaaaaaaaaaaaay over! It is interesting, and it was fun to puzzle with it for a little bit, but the amount of time (and tutoring) it would take for me to complete (let alone understand) this activity does not seem worth the investment of time for me (since this will not be helpful knowledge for my classroom or any other life situation that I can think of being involved in). Sorry! KUDOS to all of you who get it! :)

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DNA Coding strand ATGTCTCCTAGTCAA
Acording with the video
A--T  G--C
DNA template strand
TACAGAGGATCAGTT
but I don´t know anything about DNA I am a primary teacher and the activity was interesting but too difficult

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I don't know the answer to the last question and am not interested enough to search for an answer, sory. The task was intesting, I did learn a lot about DNA and I finaly understand what the Cryser method is. But enough of that please, I'm a physicist :)

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DNA template:
TAC AGA GGA TCA GTT
mRNA:
AUG UCU CCU AGU CAA
tRNA:
UAC AGA GGA UCA GUU
Amino acid normal:
Met Ser Pro Ser Gln
Amino acid mutated:
Met Cys Pro Ser Gln
Mutant mRNA:
AUG UGU CCU AGU CAA
Mutant DNA:
ATG TGT CCT AGT CAA
1)Methionin 2)It is removed

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DNA coding strans: ATGTCTCCTAGTCAA;
DNA template strand: TACAGAGGATCAGTT;
mRNA codons: AUG; UCU; CCU; AGU; CAA
tRNA anticodons: UAC; AGA; GGA; UCA; GUU
Amino acid sequence normal: Met; Ser; Pro; Ser; Gln
Amino acid sequence mutant: Met; Cys; Pro; Ser; Gln
Mutant mRNA: AUG; UGU; CCU; AGU; CAA
Mutant DNA coding strand: ATGTGTCCTAGTCAA
Answer questions:
1- Met - methionine

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I have some answers pending that I do not know at the moment. I will investigate and share again.

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3.4 Ethics, life sciences. Activity.docx

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Start codon is Met. I found this task difficult as i have never used this type of wheel before and didn't fully understand how to use it.

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DNA coding strand:
ATG TCT CCT AGT CAA
DNA template strand:
TAC AGA GGA TCA GTT
mRNA codons:
AUG UCU CCU AGU CAA
tRNA anticodons:
UAC AGA GGA UCA GAA
AA sequence wt:
Met Ser Pro Ser Gln
AA sequence mut:
Met Cys Pro Ser Gln
Mutant mRNA:
AUG UGU CCU AGU CAA
Mutant DNA cds:
ATG TGT CCT AGT CAA

The first codon codes for the aa methionine.
While all start codons (even GUG or UUG) code for methionine or fMet, due to post transcriptional processing of the proteins the N-terminal aa may actually not be the first in the final protein.

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DNA Coding atarted: ATG TCT CCT AGT CAA
DNA Template started: TAC AGA GGA TCA GTT
mRNA Codons: AUG UCU CCU AGU CAA
tRNA Anticodons: UAC AGA GGA UCA GUU
Amino acid sequence:
Normal PDST beta1: Met  Ser, Pro, Ser, Gln
Mutant PDST beta 1: Met, Cys, Pro, Ser, Gln
Mutant mRNA: AUG, UGU, CCU, AGU, CAA
Mutant DNA Coding strand: ATG TGT CCT AGT CAA
Answer Questions:
1. Met
2. becouse Met is removed after protein synthesis
PS.
My friend biology teacher help me, i didnt understand this experience here. It was ununderstnding

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Dorota, Poland

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DNA Coding strand:
ATG TCT CCT AGT CAA
DNA Template strand:
TAC AGA GGA TCA GTT
mRNA Codons:
AUG UCU CCU AGU CAA
tRNA Anticodons:
UAC AGA GGA UCA GUU
Mutant mRNA:
AUG UGU CCU AGU CAA
Mutant DNA Coding strand:
ATG TGT CCT AGT CAA

Question 1: Methionine

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DNA Coding strand:
ATG TCT CCT AGT CAA
DNA template strand:
TAC AGA GGA TCA GTT
mRNA codons:
AUG UCU CCU AGU CAA
tRNA Anticodons:
UAC AGA GGA UCA GUU
Amino acid sequence normal PDSTß1:
I'm not sure.
Amino acid sequence mutated PDSTß1:
I'm not sure.
Mutant mRNA:
I'm not sure.
Mutant DNA Coding strand:
I'm not sure.

A 1: Met
A 2:  Because, start codon AUG.

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I think I have to take help of my head to solve this. This seems too difficult for me. I need to learn alot.

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hummm ... i must review my biochemistry lessons!!! I can match DNA and RNA sequences but use the Wheel!!!!!...
Q1-  after webconsulting , start codon= Met (AUG)
Q2 - ?????

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I don't think I can do it at the moment. I need to lean a lot....

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DNA Coding strand:
ATG TCT CCT AGT CAA

DNA Template strand:
TAC AGA GGA TCA GTT

mRNA codons:
AUG UCU CCU AGU CAA

tRNA Anticodons:
UAC AGA GGA UCA GUU

Amino acid sequence Normal  PDSTß1:
Met Ser Pro Ser Gln

Amino acid sequence Mutated PDSTß1:
Met Cys Pro Ser Gln

Mutant mRNA:
AUG UGU CCU AGU CAA

Mutant DNA Coding strand:
ATG TGT CCT AGT CAA

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Since I am an electrical engineer, this is difficult exercise for me.

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DNA Coding strand:
ATG TCT CCT AGT CAA
DNA template strand:
TAC AGA GGA TCA GTT
mRNA codons:
AUG UCU CCU AGU CAA
tRNA Anticodons:
UAC AGA GGA UCA GUU
Amino acid sequence normal PDSTß1:
Met Ser Pro Ser Gln
Amino acid sequence mutated PDSTß1:
Met Cys Pro Ser Gln
Mutant mRNA:
AUG UGU CCU AGU CAA
Mutant DNA Coding strand:
ATG TGT CCT AGT CAA

Question 1: Methionine,
Question 2:  Start codon AUG also codes for methionine and without start codon translation does not happen. And even the ambiguous codon GUG codes for methionine when it is first. So does this mean that all proteins start with methionine as the first amino acid.

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I am a physicist and this is a difficult exercise for me.

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uff... DNA... biology... not my field...

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unfortunatelly I have forgotten how to do this exercise. To difficult for me.

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I hope you can read it^^ :)

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DNA Coding strand:

ATG TCT CCT AGT CAA

DNA template strand:

TAC AGA GGA TCA GTT

mRNA codons:

AUG UCU CCU AGU CAA

tRNA Anticodons:

UAC AGA GGA UCA GUU

Amino acid sequence normal PDSTß1:

Met Ser Pro Ser Gln

Amino acid sequence mutated PDSTß1:

Met Cys Pro Ser Gln

Mutant mRNA:

AUG UGU CCU AGU CAA

Mutant DNA Coding strand:

ATG TGT CCT AGT CAA

1.  Start codon = AUG = Methionine

2.  Because bacteria can use the alternative start codons GUG und UUG besides AUG.

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I’m not sure it is correct. About the last question I don’t know what answer. The Met codon is a start sign too but what is the mechanism why some time is read as start sign and some time as Met?

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Hi. I did find the activity tough but it was a great learning experience. Moreover, I looked at all my fellow colleagues answers to check my responses. Few answers I could not attempt as I could not understand.

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DNA strand:
ATG TCT CCT AGT CAA
DNA Template:
TAC AGA GGA TCA GTT
mRNA codes:
AUG UCU CCU AGU CAA
tRNA Anticodons:
UAC AGA GGA UCA GUU
Amino acid sequence:
normal PDSTβ1:
Met Ser Pro Ser Gln
mutant PDSTβ1 :
Met Cys Pro Ser Gln
mutant mRNA :
AUG UGU CCU AGU CAA
mutant DNA Coding strand:
ATG TGT CCT AGT CAA

Questions:
1. Met
2. All proteins don't have the Met amino acid as their first because of the mutation.

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I am an English teacher and a Natural Sciences teacher in Primary Education.
I don´t
understand the activity

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·         DNA Coding strand: ATG TCT CCT AGT CAA

·         DNA Template strand: TAC AGA GGA TCA GTT

·         mRNA Codons: AUG UCU CCU AGU CAA

·         tRNA Anticodons: UAC AGA GGA UCA GUU

·         Normal PDSTβ1 : Met Ser Pro Ser Gln

·         Mutant PDSTβ1: Met Cys Pro Ser Gln

·         Mutant mRNA: AUG UGU CCU AGU CAA

·         Mutant DNA Coding strand: ATG TGT CCT AGT CAA

·         Questions:

1.       Methionin

2.       Methionin is removed after protein synthesis thus not all proteins start with it

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1. Methionine
2. Because it has been removed after synthesis

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Continued answer to question 2:
Post-translational modification of proteins: proteases remove unnecessary fragments, various functional groups are added.

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1. What amino acid does the start condon encode?
methionine
2. Why don't  all proteins have the amino acid as their first?
I'm not sure, but it would be remove after synthesis.

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Inquiry based Teaching Inside the course "Inquiry based teaching in life science", I have to search and learn about the C...

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Interesting but quite difficult for a teacher...

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DNA Coding strand:
ATG TCT CCT AGT CAA
DNA Template strand:
TAC AGA GGA TCA GTT
mRNA Codons:
AUG UCU CCU AGU CAA
tRNA Anticodons:
UAC AGA GGA UCA GUU

Normal PDSTβ1
Met Ser Pro Ser Gln

Mutant PDSTβ1:
Met Cys Pro Ser Gln
Mutant mRNA:
AUG UGU CCU AGU CAA
Mutant DNA Coding strand:
ATG TGT CCT AGT CAA

Answers:
1) Methionin
2) All
proteins don’t have this amino acid because of the    introduced single point mutation,  the sequence of the coding DNA  strand can be altered to bring about the required change in protein  can alter and change

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1. What amino acid does the start codon encode?
methionine
2. Why don't all proteins have this amino acid as their first?
The first amino acid in the protein depends on the start codon, which is different.
Therefore, the first amino acid in the protein can also be different.
E.g:
- in Prokaryote, the codon Start is AUG, coding for formylmethionine,
- for some Prokaryotes there is an alternative Start GUG codon encoding valine,
- at Eukaryota, the codon Start is AUG, coding for methionine.
Are the start codons in mRNA in the mitochondria and chloroplasts different, I don't know.

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Had to do some research for this one. Here are my workings:

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Interesting, but difficult for me ...

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I didn't know that I am a genetic engineer...:) I thought that I'm a physics teacher. But challenge accepted!

,1. Met (methionine)
2. I suppose that there are many other proteins and their codons don't necessary start with AUG...
Target codon is closer to the start codon, so the solution would be the 2nd one.

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DNA strand:
ATG TCT CCT AGT CAA
DNA Template:
TAC AGA GGA TCA GTT
MRNA codes:
AUG UCU CCU AGU CAA
tRNA Anticodons:
UAC AGA GGA UCA GUU
PDSTβ1 normal:
Met Ser Pro Ser Gln
PDSTβ1 mutant:
Met Cys Pro Ser Gln
MRNA mutant:
AUG UGU CCU AGU CAA
Filament Mutant DNA Coding:
ATG TGT CCT AGT CAA

Questions:
1) Met
2) because methionine is removed after protein synthesis

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Although it seems interesting, quite difficult for a physicist..

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Good

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Answers

1. Methionine.

2. Because sometimes polypeptide chains may undergo post-translational modification to form the mature protein product.

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DNA strand:
ATG TCT CCT AGT CAA
DNA Template:
TAC AGA GGA TCA GTT
MRNA codes:
AUG UCU CCU AGU CAA
tRNA Anticodons:
UAC AGA GGA UCA GUU
PDSTβ1 normal:
Met Ser Pro Ser Gln
PDSTβ1 mutant:
Met Cys Pro Ser Gln
MRNA mutant:
AUG UGU CCU AGU CAA
Filament Mutant DNA Coding:
ATG TGT CCT AGT CAA

Questions:
1) Met
2) because methionine is removed after protein synthesis

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This activity is too difficult for me because I am a mathematics teacher and I have no idea what to do. I can only share notes with you about the theme.

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I am Biologist of National Order, I have created and realized with high school students these activities, bioenglish research activities presented also in Workshop for teacher as relator about modern biology , also about CRISPR

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DNA Coding strand:
ATG TCT CCT AGT CAA
DNA Template strand:
TAC AGA GGA TCA GTT
mRNA Codons:
AUG UCU CCU AGU CAA
tRNA Anticodons:
UAC AGA GGA UCA GUU
Normal PDSTβ1
:
Met Ser Pro Ser Gln
Mutant PDSTβ1:
Met Cys Pro Ser Gln
Mutant mRNA:
AUG UGU CCU AGU CAA
Mutant DNA Coding
strand:
ATG TGT CCT AGT CAA

Questions:
1) Methionin
2) All proteins don’t
have this amino acid as their first because of posttranslational modification.

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DNA Coding strand:
ATG TCT CCT AGT CAA
DNA Template strand:
TAC AGA GGA TCA GTT
mRNA Codons:
AUG UCU CCU AGU CAA
tRNA Anticodons:
UAC AGA GGA UCA GUU
 Normal PDSTβ1 :
Met Ser Pro Ser Gln
Mutant PDSTβ1:
Met Cys Pro Ser Gln
Mutant mRNA:
AUG UGU CCU AGU CAA
Mutant DNA Coding strand:
ATG TGT CCT AGT CAA

Questions:
1) Methionin
2) All proteins don’t have this amino acid as their first because of posttranslational modification.

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I am a math teacher so I have no idea about this .

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I think this activity is very specific for a certain science.
I teach Mathematics, so it's not my field of work and I do not know how to solve this activity. I tried to understand and do online research to solve the problem, but I'm afraid the answers iI found might not be correct.

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1. Methionine
2. There are otheer codons to initiate the synthesis, particularly in Prokaryotes, like UUG

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I teach in the Primary school.  I am sorry but it's not from the field  and I don not know how to solve this activity.

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I am not from this field either. So, I have some problems to solve this activity

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too time consuming as I am not on this field.
Sorry

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I have been trying tounderstand this activity but I am affraid that I don't know to solve it. I am sorry.

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ATG-TCT-CCT-AGT-CAA
TAC-ACA-GGA-TCA-GTT
mRNA
AUGUCUCCUAGUCAA
tRNA
UACAGAGGAUCAGUU
Normal PDSTB1
Met-Ser-Pro-SEr-Gln
Mutant PDSTB1
Met-Cys-Pro-Ser-Gln
Mutant DNA
ATG-TGT-CCT-ACT-CAA
Mutant RNA
AUG-UGU-CCU-AGU-CAA

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ATG-TCT-CCT-AGT-CCA
TAC-AGA-GGA-TCA-GTT
mRNA CODON
AUG-UCU-CCU-AGU-CAA
tRNA anticodon
UAC-AGA-GGA-UCA-GUU
Normal PDS..
Met-ser-pro-ser-gln
Mutant mRNA
AUG-UGU-CCU-AGU-CAA
Mutant PDS
Met-Cys-Pro-Ser-gln
Mutant DNA
ATG-TGT-CCT-AGT-CAA

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DNA Coding strand:
ATG TCT CCT AGT CAA
DNA Template strand:
TAC AGA GGA TCA GTT
mRNA Codons:
AUG UCU CCU AGU CAA
tRNA Anticodons:
UAC AGA GGA UCA GUU
Normal PDSTβ1 :
Met Ser Pro Ser Gln
Mutant PDSTβ1:
Met Cys Pro Ser Gln
Mutant mRNA:
AUG UGU CCU AGU CAA
Mutant DNA Coding strand:
ATG TGT CCT AGT CAA

Questions:
1) Met
2) Because of post-translational modification

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DNA Coding Strand
--ATG-TCT-CCT-AGT-CAA--
DNA Template
--TCA-AGA-GGA-TCA-GTT--
mRNA CODONS
--AUG-UCU-CCU-AGU-CAA--
tRNA ANTICODONS
--UAC-AGA-GGA-UCA-GUU--

PROTEIN
NORMAL
--Met-Ser*-Pro-Ser-Gln--
MUTANT
--Met-Cys*-Pro-Ser-Gln--

MUTANT mRNA
--AUG-UG*U-CCU-AGU-CAA-
MUTANT DNA CODING STRAND
--ATG-TG*T-CCT-AGT-CAA--