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Beginning in late 1941, the Germans began mass transports from the ghettoes in Poland to the concentration camps, starting with those people viewed as the least useful: the sick, old and weak and the very young. The first mass gassings began at the camp of Belzec, near Lublin, on March 17, 1942. Five more mass killing centers were built at camps in occupied Poland, including Chelmno, Sobibor, Treblinka, Majdanek and the largest of all, Auschwitz-Birkenau. From 1942 to 1945, Jews were deported to the camps from all over Europe, including German-controlled territory as well as those countries allied with Germany. The heaviest deportations took place during the summer and fall of 1942, when more than 300,000 people were deported from the Warsaw ghetto alone. Fed up with the deportations, disease and constant hunger, the inhabitants of the Warsaw Ghetto rose up in armed revolt. The Warsaw Ghetto Uprising from April 19-May 16, 1943 ended in the death of 7,000 Jews, with 50,000 survivors sent to extermination camps. But the resistance fighters had held off the Nazis for almost a month, and their revolt inspired revolts at camps and ghettos across German-occupied Europe.

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In September 1939, the German army occupied the western half of Poland. German police soon forced tens of thousands of Polish Jews from their homes and into ghettoes, giving their confiscated properties to ethnic Germans (non-Jews outside Germany who identified as German), Germans from the Reich or Polish gentiles. Surrounded by high walls and barbed wire, the Jewish ghettoes in Poland functioned like captive city-states, governed by Jewish Councils. In addition to widespread unemployment, poverty and hunger, overpopulation made the ghettoes breeding grounds for disease such as typhus.

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Anti-Semitism in Europe did not begin with Adolf Hitler. Though use of the term itself dates only to the 1870s, there is evidence of hostility toward Jews long before the Holocaust–even as far back as the ancient world, when Roman authorities destroyed the Jewish temple in Jerusalem and forced Jews to leave Palestine. The Enlightenment, during the 17th and 18th centuries, emphasized religious toleration, and in the 19th century Napoleon and other European rulers enacted legislation that ended long-standing restrictions on Jews. Anti-Semitic feeling endured, however, in many cases taking on a racial character rather than a religious one.

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The twin goals of racial purity and spatial expansion were the core of Hitler’s worldview, and from 1933 onward they would combine to form the driving force behind his foreign and domestic policy. At first, the Nazis reserved their harshest persecution for political opponents such as Communists or Social Democrats. The first official concentration camp opened at Dachau (near Munich) in March 1933, and many of the first prisoners sent there were Communists.