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"So that thus it is that natural men are held in the hand of God over the pit of hell. They have deserved the fiery pit, and are already sentenced to it; and God is dreadfully provoked, His anger is as great toward them as to those that are actually suffering the executions. "
It states that people who haven't been reborn are already destined to go to hell. God is provoked by these natural men and he is making them suffer

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"the devil is waiting for them, hell is gaping for them, the flames gather and flash about them, and would fain lay hold on them, and swallow them up; the fire pent up in their own hearts is struggling to break out: And they have no interest in any Mediator, there are no means within reach that can be any security to them."
This means that the devil is waiting for those natural men and hell is waiting for them and both the devil and hell is will both gladly be of hold of them. They have no interest in the mediator which is Jesus Christ.

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“God upon your souls; all you that were never born again,and make new creatures, and raised from being dead in sin” meaning that people who have made a sin will not be reborn again to make new life and wont be raised from the dead ever again