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How Artemisinin Works Artemisinin is used against the falciaparum strain of malaria. It acts very quickly, reducing the parasite's biomass in the human body, and is particularly effective at destroying drug-resistant malarial parasites in the bloodstream. Artemisinin works like many anti-malaria drugs by attacking the malaria parasite's sexual stage of its life cycle, preventing the multiplication of parasites that fuels the infection. The drug also gets rid of the asexual forms of the parasite faster than any known treatment. The main chemical feature of artemisinin is an unstable bond between two oxygen atoms that generates free radicals that break up proteins in the protozoa. The release occurs upon exposure to Hemozoin, the dark granular digest of hemoglobin that accumulates in plasmodium-infected blood cells. Artenisinin disrupts the transfer of the parasite from humans to mosquitoes. Because it throws off the whole malaria cycle it also holds great promise eradicating malaria from areas where it used. Artemisinin works very fast, which is mostly a good thing but the downside is that the drug dissipates quickly in the bloodstream and patients need to take it for seven days to allow it to do its thing. But if artemisinin is combined with another drug such as mefloquin the course can be reduced to three days. The two-drug cocktail also offers protection from future resistance to artemisinin. The cost of these treatments is about $2 a course, considerably more expensive than 10 cents for chloroquine. The cost of some artemisinin-based drugs is about $1 per treatment.

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How Artemisinin Works Artemisinin is used against the falciaparum strain of malaria. It acts very quickly, reducing the parasite's biomass in the human body, and is particularly effective at destroying drug-resistant malarial parasites in the bloodstream. Artemisinin works like many anti-malaria drugs by attacking the malaria parasite's sexual stage of its life cycle, preventing the multiplication of parasites that fuels the infection. The drug also gets rid of the asexual forms of the parasite faster than any known treatment. The main chemical feature of artemisinin is an unstable bond between two oxygen atoms that generates free radicals that break up proteins in the protozoa. The release occurs upon exposure to Hemozoin, the dark granular digest of hemoglobin that accumulates in plasmodium-infected blood cells. Artenisinin disrupts the transfer of the parasite from humans to mosquitoes. Because it throws off the whole malaria cycle it also holds great promise eradicating malaria from areas where it used. Artemisinin works very fast, which is mostly a good thing but the downside is that the drug dissipates quickly in the bloodstream and patients need to take it for seven days to allow it to do its thing. But if artemisinin is combined with another drug such as mefloquin the course can be reduced to three days. The two-drug cocktail also offers protection from future resistance to artemisinin. The cost of these treatments is about $2 a course, considerably more expensive than 10 cents for chloroquine. The cost of some artemisinin-based drugs is about $1 per treatment.

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Recently, however, malaria parasites have started to adapt so the drugs won't knock them out. Resistance to artemisin-based medications has been slowly developing in Southeast Asia. And now these malaria wonder drugs look like they may be starting to lose their mojo in Africa, too. Late in 2015, health officials in Britain for the first time came across a cluster of malaria cases that refused to succumb to Artemether-lumefantrine (artemisin-based drug). The patients were travelers who had returned from three different African countries — Angola, Liberia and Uganda.

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nausea, vomiting, anorexia, and dizziness

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first activated through cleavage after reacting with haem and iron (II) oxide, which results in the generation of free radicals that in turn damage susceptible proteins, resulting in the death of the parasite

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1. https://en.wikipedia.org/wiki/Artemisinin
2.  http://www.nobelprize.org/nobel_prizes/medicine/laureates/2015/tu-bio.html
3. http://www.npr.org/sections/goatsandsoda/2017/01/31/512716015/drug-resistant-malaria-turns-up-in-the-u-k

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Artemisinin is isolated from the plant Artemisia annu, sweet wormwood, an herb employed in Chinese traditional medicine

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after studies of traditional herbal medicines, Youyou Tu managed to extract a substance, artemisin, which inhibits the malaria parasite. Drugs based on artemisin have led to the survival and improved health of millions of people

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Hi