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Paper 1:A systematic review and meta-analysis of venous thrombosis risk among users of combined oral contraception 

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Paper 1:A systematic review and meta-analysis of venous thrombosis risk among users of combined oral contraception 

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Strengths:
Systematic review- highest on hierarchy of evidence
Clear aim
Excludes women with a Hx of venous thrombosis so finds prevalence in relation to CoC itself
Paper have been exclude that are not specific to type of oral contraceptive

Weaknesses:
-There are no data from randomized controlled trials; thus, the analysis was limited to comparative observational trials which could have resulted in biased results
- Only one study from outside of USA and Europe
-5 of the studies included did not clearly state oestrogen dose contained in the CoC examined

Accepted

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In young females, does the combined contraceptive pill increase the prevalence of venous thrombosis?

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P: females
I: combined contraceptive pill
C: other forms of contraception
O: thrombosis

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Cross sectional study due to intervention
Systematic review: verified reviews from many journals and trial summarised in one paper

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1: Pubmed- provides a combination of up to date RCTs and systematic reviews
2: Cochrane Library - provides systematic reviews which are the highest level of the hierarchy of evidence
3: Trip- Allows for PICO search ensuring catered results without Boolean operators
4: CINHL- database catered towards nursing

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Search Pubmed
Boolean Operators: contraceptive pill AND thrombosis
Articles 2016-2021
Systematic reviews

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Paper 2:Different combined oral contraceptives and the risk of venous thrombosis: systematic review and network meta-analysis

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Paper 2:Different combined oral contraceptives and the risk of venous thrombosis: systematic review and network meta-analysis

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Strengths:
-Systematic review & metananlysis - highest evidence on hierarchy of evidence
-Focused on clear question
-Authors looked for best evidence- no RCT available
- Studies worldwide and not limited to english publications

Weaknesses:
- random 10 CoC examined: not considering prevalence of prescription
-Age of participants was not catered for when selecting studies, and due to higher risk of VT in older women
-Dosage of oestrogen not stated in some of the studies reviewed

Answered the question but rejecting as 30% of studies used were not specific

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CoC does have a link with venous thrombosis