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https://cen.acs.org/pharmaceuticals/vaccines/Adenoviral-vector-vaccine-data-both-promising-and-perplexing/98/i46

https://news.emory.edu/stories/2020/11/stealth_bomber_virus_vs_cancer/index.html

https://gulfnews.com/uae/health/uae-launches-phase-3-trial-for-russian-human-adenovirus-based-covid-19-vaccine-1.1607359273244

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https://www.youtube.com/watch?v=QM5kOHRQuQc

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Abimbola O Kolawole; PhD, Biomedical Sciences, Wright State University, Dayton, Ohio, USA
https://corescholar.libraries.wright.edu/biology/561/

https://bio-protocol.org/UserHome.aspx?id=1235141

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https://healthonecares.com/specialties/cardiology/

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CRISPR-Cas9 gene editing has made it possible to edit genes in various target cells. The article, "Production of isoform-specific knockdown/knockout Madin-Darby canine kidney epithelial cells using CRISPR/Cas9," highlights how CRISPR-Cas9 gene editing has been used to identify how adenovirus enters polarized epithelia from the apical surface.

The figure below depicts parental MDCK cells and JR1-CAREx8-KO MDCK cells showing similar morphology. Both cell types were seeded on chamber slides at similar concentrations and bright field microscopy images were taken 24, 48, and 72 hours after seeding.
https://pubmed.ncbi.nlm.nih.gov/33304833/

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"The first line of prevention is frequent hand washing
(good hand hygiene). Avoid touching your eyes, nose
and mouth with unwashed hands.

Disinfection of fomites [fo-mites] (clothes, utensils
and furniture) is difficult as the virus is resistant to
many disinfectants. Clean surfaces with heat or bleachcontaining products.

People who have infection and are in the hospital need
to be in isolation. You should try to avoid close contact
with those who are sick. Anyone who is ill with the virus
should stay home and avoid spreading the infection
further. Virus shedding (released from the body) can
continue for days to weeks even after the person
recovers from the acute illness, therefore those who
were infected can still spread to others even when they
appear well."
https://www.thoracic.org/patients/patient-resources/resources/adenovirus.pdf

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"Adenovirus can be isolated by growing in cell cultures
in a laboratory for several days. However, there are now
rapid laboratory tests to diagnose adenoviral infection
using nasal or throat swabs or sputum samples.

These tests use molecular based PCR and antigen
detection to detect the presence of the virus without
having to grow it. In severe cases, the virus can be
detected in the blood. Chest x-rays may show signs
of pneumonia but the findings are not specific for
adenovirus.

Many people with adenovirus infection do not require
treatment due to the mild nature of symptoms.
Supportive care may include control of nasal secretions
with saline washes and suctioning. Breathing
treatments may be helpful for some people with
hypertonic saline or albuterol.
However, in some people, adenovirus can lead to severe
disease and even death. People who have respiratory
failure or severe GI symptoms, or people who have low
immune function (immunocompromised) may need
treatment with an antiviral medication such as cidofovir.
Follow up lab viral testing can be used to monitor
response to treatment."
https://www.thoracic.org/patients/patient-resources/resources/adenovirus.pdf

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1. Cough
2. Fever
3. Rapid breathing
4. Wheezing
5. Rapid breathing
https://www.thoracic.org/patients/patient-resources/resources/adenovirus.pdf

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American Thoracic Society. (2020). Adenovirus Infection and Outbreaks: What You Need to Know. Retrieved on December 13, 2020 from https://www.thoracic.org/patients/patient-resources/resources/adenovirus.pdf

Centers for Disease Control and Prevention. (2020). Adenoviruses. Retrieved on December 13, 2020 from https://www.cdc.gov/adenovirus/index.html

Cross, R. (2020, November 24).

Adenoviral vector vaccine data both promising and perplexing. Retrieved on December 13, 2020 from https://cen.acs.org/pharmaceuticals/vaccines/Adenoviral-vector-vaccine-data-both-promising-and-perplexing/98/i46

Eastman, Q. (2020, November 30). Engineered 'stealth bomber' virus could be new weapon against metastatic cancer. Retrieved on December 13, 2020 from https://news.emory.edu/stories/2020/11/stealth_bomber_virus_vs_cancer/index.html

HealthONE. (2020). Adenovirus. Retrieved on December 13, 2020 from https://healthonecares.com/specialties/cardiology/

Readler, J. M., AlKhout, A. S., Kolawole, A. O., & Excoffon, K. J. (2020). Production of isoform-specific knockdown/knockout Madin-Darby canine kidney epithelial cells using CRISPR/Cas9. MethodsX, 101149.

University of Pennsylvania. (2020). Adenovirus. Retrieved on December 13, 2020 from https://pathbio.med.upenn.edu/pbr/portal/hist/F19-adeno.html

WebMD. (2020). What Are Adenovirus Infections? Retrieved on December 13, 2020 from https://www.webmd.com/children/adenovirus-infections#1

Zaman, S. (2020, December 7).

UAE launches Phase 3 trial for Russian human adenovirus-based COVID-19 vaccine. Retrieved on December 13, 2020 from https://gulfnews.com/uae/health/uae-launches-phase-3-trial-for-russian-human-adenovirus-based-covid-19-vaccine-1.1607359273244

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Adenovirus
https://pathbio.med.upenn.edu/pbr/portal/hist/F19-adeno.html

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"Adenoviruses are a group of common viruses that infect the lining of your eyes, airways and lungs, intestines, urinary tract, and nervous system. They're common causes of fever, coughs, sore throats, diarrhea, and pink eye.

Infections happen in children more often than in adults, but anyone can get them. Most kids will have at least one type of adenovirus infection by the time they’re 10.

The infections usually cause only mild symptoms and get better on their own in a few days. But they can be more serious in people with weak immune systems, especially children."

https://www.webmd.com/children/adenovirus-infections#1

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https://www.cdc.gov/adenovirus/index.html