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Treatment involves administration of post-exposure rabies shots as soon as the person is exposed to the virus, once the signs and symptoms manifest no effective treatment is available

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Leave all wildlife alone.
Know the risk: contact with infected bats is the leading cause of rabies deaths in people in the U.S., followed by exposure to rabid dogs while traveling internationally.
Wash animal bites or scratches immediately with soap and water.
If you are bitten, scratched, or unsure, talk to a healthcare provider about whether you need postexposure prophylaxis. Rabies in people is 100% preventable through prompt appropriate medical care.
Vaccinate your pets to protect them and your family.

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A diagnosis of rabies can be made after detection of rabies virus from any part of the affected brain, but in order to rule out rabies, the test must include tissue from at least two locations in the brain, preferably the brain stem and cerebellum.

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The first symptoms of rabies may be very similar to those of the flu including general weakness or discomfort, fever, or headache. These symptoms may last for days.

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Rabies is a preventable viral disease most often transmitted through the bite of a rabid animal. The rabies virus infects the central nervous system of mammals, ultimately causing disease in the brain and death. The vast majority of rabies cases reported to the Centers for Disease Control and Prevention (CDC) each year occur in wild animals like bats, raccoons, skunks, and foxes, although any mammal can get rabies.

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Rabies virus is spread through direct contact (such as through some broken skin or mucous membranes located in the eyes, nose, or mouth) with saliva or brain/nervous system tissue from an infected organism.