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CFan Team Members and their Strengths:

Alice- Achiever
Andrew- Activator
Amelia- Adaptability
Faith- Futuristic
Randal- Responsibility

Alice was chosen for her strength as an achiever. She has a strong inner drive that will motivate the team to work hard and get things done.

Andrew was selected for his strength as an activator. He will
be the energy source to the team putting our thoughts into action and make sure others are heard.

Amelia was picked for her strength of adaptability. She will hold the team together and will keep us in balance during unpredictable events.

Faith was selected for her strength of futuristics. She will inspire and motivate the team with her innate creativity and imagination of visions of the future.

Randall was chosen for his strength of responsibility. His commitment to stable values, such as honesty and loyalty, will detour the team from any unethical behavior.

Go, Team CFAN

(Modified by EFO 2017; Talent Themes/Strengths Quick Reference Guide, Created by Housing and Residential Life at the University of Minnesota. Clifton StrengthsFinder®, StrengthsFinder®, StrengthsQuest®, and each of the 34 Clifton StrengthsFinder theme names are trademarks of Gallup, Inc. All rights reserved.)

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Top 5 Strengths:

“Top 5 Clifton Strengths: learner, harmony, positivity, discipline, and includer”.

As a learner, I am committed to the journey of learning, not just the outcome. Harmony is one of my guiding values: promoting peace, incorporating a team approach, and fostering collaboration for efficacy. I believe words of positivity are needed daily, and achievements, no matter how small, should be recognized with celebration. Discipline is a principle I will practice daily with my team to ensure progress, productivity, and security. As an includer, I feel that each member of the team is equally invaluable.

(Gallop Clifton Strengths, 2018)

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Ates, H.C., Bruch,R., Dincer, C., Flamm, B., Glatz, R.T.,
Hofflin,     N., Hug, M.J., Lozano-Zahonero, Sara.,
Schmidt, J., Schumann, S., Streicher, L., Trittler, R.,
Wagner, H.J., Weber, W.,  & Wenzel, C., (2021).
Biosensor-Enabled Multiplexed  On-Site Therapeutic
Drug Monitoring of Antibiotics., Advanced Materials.
https://doi.org/10.1002/adma.202104555

Becker, F. & University of Freiburg. (2021). Antibiotic levels
measurable in breath for first time (VIDEO). Eureka
Alert. https://www.pr.uni-freiburg.de/pm-en/press-
releases-2021/antibiotic-levels-measurable-in-
breath-for-first-time

Hastings, C., (2021). Chip Detects Antibiotic in
Exhaled Breath. Medgadget:
https://www.medgadget.com/2021/09/chip-

detects-breath.html

Modified by EFO 2017; Talent Themes/Strengths Quick
Reference Guide, Created by Housing and Residential
Life at the University of Minnesota. Clifton
StrengthsFinder®, StrengthsFinder®,
StrengthsQuest®, and each of the 34 Clifton
StrengthsFinder theme names are trademarks of
Gallup, Inc. All rights reserved.

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Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

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Antibiotic levels measurable in breath for first time

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Freiburg researchers Dr. Can Dincer and H. Ceren Ates are testing a biosensor for personalized dosing of medications

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Antibiotic therapy is usually the last resort to treat an illness. The healing process depends on accurate levels to effectively treat an infection. Currently, the only way to evaluate if a therapeutic antibiotic level has been attained is through point-of-care testing or noninvasive sampling which takes time to receive the results.  The introduction to the biosensor that enables on-site therapeutic drug monitoring (TDM) offers practitioners better patient care management, ensures optimal antibiotic concentration, minimizing side effects, and preventing drug resistance due to insufficient dosing.

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Cons of Biosensor Monitoring of Antibiotic Levels 

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Cons of Biosensor Monitoring of Antibiotic Levels 

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Keeping blood antibiotic concentrations within therapeutic range requires frequent sampling (Ates et al., 2021).

Accessible information from exhaled breath condensate(EBC)
involves a time delay and a history of concentration changes. (Ates et al., 2021).

Samples measured concentrations in noninvasive samples have many uncertainties due to inter-patient variance and exogenous factors (Ates et al., 2021)

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Pros of Biosensor Monitoring of Antibiotic Levels

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Pros of Biosensor Monitoring of Antibiotic Levels

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Rapid point of care antibiotic testing possibly enabling customized pharmaceutical treatment (Ates et al., 2021).

Reporting the correct levels of antibiotics to effectively treat an infection (Ates et al., 2021).

Avoiding drug side effects or the development of antibiotic-resistant bacteria (Ates et al., 2021).

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Biosensor-Enabled Multiplexed On-Site Therapeutic Drug Monitoring of Antibiotics

https://doi.org/10.1002/adma.202104555

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Scientists at the University of Freiburg in Germany have developed a biosensor that measures the antibiotic levels in the breath that enables rapid and non-invasive antibiotic testing (Ates et al., 2021). The chip uses synthetic proteins similar to ones used by resistant bacteria to sense antibiotics in their environment (Ates et al., 2021).

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H. Ceren Ates,Hasti Mohsenin,Christin Wenzel,Regina T. Glatz,Hanna J. Wagner,Richard Bruch,Nico Höfflin,Sashko Spassov,Lea Streicher,Sara Lozano-Zahonero,Bernd Flamm,Rainer Trittler,Martin J. Hug,Maja Köhn,Johannes Schmidt,Stefan Schumann,Gerald A. Urban,Wilfried Weber,Can Dincer.

First published: 21 September 2021

Wiley Online Library

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Published September 29th, 2021 (Hastings, 2021)

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Researchers at the University of Freiburg in Germany have developed a chip that can measure antibiotic levels in breath, potentially paving the way for rapid point-of-care antibiotic testing. Attaining the correct levels of antibiotics in the body is crucial to effectively treating infections and avoiding drug side-effects or the development of antibiotic-resistant bacteria. The chip enables rapid and non-invasive antibiotic testing, potentially allowing for personalized drug therapy.

Antimicrobial resistance is a growing issue, and owes its proliferation to incorrect antibiotic usage. If administered at too low a dose, resistant microbes can survive and proliferate, contributing to treatment failure and antibiotic resistance. If the dose is too high, then drug side effects can be an issue. However, simply administering the 'right' dose is tricky as each patient responds differently, with inter-individual differences in metabolism potentially contributing to drastically different concentrations of an administered antibiotic reaching and staying in the blood.

The best way to personalize antibiotic therapy is to directly measure drug levels in the body after administering a dose, and then adjust the dose as necessary to maintain drug levels within an optimal therapeutic window. However, there is a lack of techniques that allow for rapid and non-invasive antibiotic testing.

This is where this latest technology aims to make a difference. The chip uses synthetic proteins that are similar to those used by resistant bacteria to sense antibiotics in their environment. "You could say we are beating the bacteria at their own game," said Wilfried Weber, a researcher involved in the study, in a press release.

The small microfluidic chip contains the proteins, which are fixed in place on a polymer film. The antibiotic in a breath sample binds to the proteins, generating a change in an electrical current. "Until now researchers could only detect traces of antibiotics in the breath. With our synthetic proteins on a microfluidic chip, we can determine the smallest concentrations in the breath condensate and they correlate with the blood values," said Can Dincer, another researcher involved in the study.

So far, the team validated that the results from breath analysis correlate with those from blood samples, suggesting that the technology is viable for reliable non-invasive testing.

Take a look at a video at this link for more about the technology...

Study in Advanced Materials: Biosensor-Enabled Multiplexed On-Site Therapeutic Drug Monitoring of Antibiotics

Via: University of Freiburg

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Chip Detects Antibiotics in Exhaled Breath

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Researchers at the University of Freiburg in Germany have developed a chip that can measure antibiotic levels in breath, potentially paving the way for rapid point-of-care antibiotic testing. Attaining the correct levels of antibiotics in the body is crucial to effectively treating infections and avoiding drug side-effects or the development of antibiotic-resistant bacteria.

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Antibiotic Levels Measured with Breath Analysis 

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Antibiotic Levels Measured with Breath Analysis 