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My final reaction to this quote is that yes, since sleep is such a vital part for our health, it will be understandably disturbed when we are stressed/feel guilt over something. Shakespeare must have felt the same way. At first glance, this quote means exactly this: sleep is important, and there are many reasons you can lack it.

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King Duncan is peacefully, innocently sleeping when he is murdered.

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Lady Macbeth's sleep is disturbed by sleepwalking because of her extreme guilt over all the Macbeth murders.

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Until Macbeth can undo his sin, and clean his hands free of blood, will he be able to peacefully sleep. He can do neither.

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Macbeth can't sleep because he faces extreme guilt over his murderous sin. He fears the judgement of his peers and of the afterlife.

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Macbeth would lie awake the first night he murders Duncan, as "he hath murdered sleep."

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http://www.chroniclet.com/browns-notes/2016/10/17/Coach-Hue-Jackson-can-t-sleep-after-controversial-decision-falling-to-0-6-more-determined-than-ever-to-turn-around-Browns.html
Cleveland Browns coach Hue Jackson faces a sleepless night after making one of the most major decisions of his life on game management after his team has faced only losses for for weeks. He worries about the people involved and the future. Similarly, Macbeth is anxious constantly for his "fate" and future. Did he make the right decision to murder Duncan? Was it worth it? It is a sleepless night for Macbeth as well, when he goes through his murderous decision.

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http://www.stuff.co.nz/travel/news/85995564/heres-why-you-dont-sleep-well-in-hotels
In this article, it establishes the phenomena of not being able to sleep at hotels as a perceived sense of danger. Because the setting is unfamiliar, the brain subconsciously stays half-awake in case something happens. Similarly, Macbeth feels guilty so he has a heightened sense of danger, of fear. "Blood will have blood", after all.

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http://www.cnn.com/2014/09/04/health/no-sleep-brain-size/
Throughout the play, as Macbeth loses sleep, he seems to lose more and more mental stability. Similar to Lady Macbeth as well, although she sleeps, it is restless and uneasy. The article talks about losing sleep shrinks the mental capacity (perhaps not physically, but definitely mentally). It explains the short tempers, the loss in focus during the day when we lose sleep. As such, a long period of time with no sleep can have deep behavioral and psychological effects (as it did on the Macbeths).

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Mr. Robot is a show about a socially inept hacker who tries to save the world from the evil roots of corporate capitalism. Little does he know, before he can save the world, he must save himself. He is severely traumatized by his past, and his mind has disassociated into two separate entities: Mr. Robot (who manifests physically as his late father) and himself (a socially inept, drug-addicted millennial), which we learn with the hacker along the road. He tries to battle the second entity (who is almost insane) from coming out by taking Aderall to stay awake, because Mr. Robot comes out when he sleeps. He lacks the season of all natures. He is plagued by Mr. Robot's guilty actions in extreme illegal activity and fear mongering intimidation and his own guilt in his father's death. He is not innocent, and therefore cannot sleep.

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11/12/16. "You lack the the season of all natures, sleep," I say to my mirror. It's 3 am. I just finished most of my UC Prompts. My mind is tired. My eyes are dead. No reply.

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11/12/12: "You lack the season of all natures, sleep," I say to my brother when I pick him up from his League Finals for Cross Country. He doesn't answer me as he dozes off. I must navigate home by myself.

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11/12/16: I wake up at 4:30 am naturally because I went to sleep really early the night before. I reply to all the texts I missed and go back to sleep. I wake back up and reply to "Bro so early" from my cousin with the quote. She replies forty minutes later with "You right" and "I just woke up".

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I never connected to something so much. Sleep is vital to our sanity/mental stability and yet it's very easy to lose it. In context, I understand that Lady Macbeth is trying to justify her husband's awkward, manic behavior. So that she doesn't have to be scared of him too. We justify our short tempers on much of the same reasoning.

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"You lack the season of all natures, sleep."