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Can be transmitted through skin to skin contact in rare cases

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the bacteria usually infects the lungs

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Requires long exposure for infection to occur

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Affects the lungs

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it can become latent in immunocompetent hosts, but dissemination of the bacteria can occur in immunocompromised hosts

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it can become latent in immunocompetent hosts, but dissemination of the bacteria can occur in immunocompromised hosts

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Not very common anymore

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it can lead to long lasting damage in the lungs

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Bacterial disease that spreads in the lungs

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typically characterized by a specific type of cough, can lay dormant for a long time until infection starts

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A bacterial infection that negatively impacts the lungs

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can be tested for by 2 step skin test or blood test

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Severe respiratory infection that mainly affects the lungs

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It infects the lungs. There are drug resistant strains of TB.

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It can be very dangerous for individuals to be around others who also have tuberculosis.

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It's a bacterial disease that has killed many. In the past, people with Tb were sent to sanatoriums.

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targets dendritic cells and macrophages in the lungs

can spread to other areas of the body like the spine

forms antibiotic resistance quite rapidly

some forms are resistant to all available antibiotics

affects about 1/3 of the global population

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Most important disease in human history 

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Most important disease in human history 

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Old vampire myths come from the way tuberculosis slowly causes a patient to deteriorate (a specific famous tb case inspired the gradual death of Lucy in the novel Dracula)

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A bacterial infection of the lungs

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Mostly affects the lungs and caused by a type of bacteria. It is also spread through the air.

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Tuberculosis involves infection of the lungs

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If someone has TB it can survive for years undetected and is mostly impossible to completely clear

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TB infection can be detected through blood and skin tests.

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most hospitals want you to test for tb before working

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Tuberculosis attacks the lungs, and was a very serious illness/very prevalent in the past. The development of a vaccine has helped eradicate it in some parts of the world

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Latent infections are possible, and public health measures may include employers requiring TB tests

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Mostly affects the lungs. Not as prevelant as it used to be due to vaccines

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Spread through the lymphatic system to created disseminated disease 

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Spread through the lymphatic system to created disseminated disease 

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Was called consumption in the 1800s due to substantial weight loss as a common symptom

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Massive ABX resistance due to slow replication

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Massive ABX resistance due to slow replication

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affect the lungs

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Provide a steady stream of immune cells for Mtb to replicate inside of

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If the granuloma doesn’t break, it keeps the bacteria from spreading throughout the body and to other people

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Provide a 'hub' of cells for MTb to replicate in

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Since TB infects macrophages, the constant accumulation of them in one place makes infection of many macrophages much easier.

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Barring any burst of the granuloma, the structure keeps the bacteria pretty well contained within one spot, preventing spread to other parts of the body.

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Provide safe space for TB to replicate without exposure to outside toxins/harmful materials

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Isolated granulomas can prevent the spread of MTb throughout the body

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Provides a good space and available cells for the infection to spread

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Constant stream of nutrients and hosts for replication

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Provides a safe place to nourish and reproduce to spread to tother parts of the body

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Provides a safe place to nourish and reproduce to spread to tother parts of the body

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They help provide an area for MTb to grow and replicate without interfering with molecules that could harm or kill them.

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granulomas can contain MTb provided that they don't break

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granulomas can contain MTb provided that they don't break

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Provides safe area to reproduce

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They function as bases for the MTb to replicate and grow while being protected/fed by infected cells

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As long as the granuloma is kept stable TB can't exit to infect more critical cells like tissue in the lungs

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Granulomas create an environment where MTb can survive

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If/when apoptotic macrophages cause a rupture, then the Mtb can spread to other places in the body, and be transmitted to other hosts as well.

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Keeps the infection contained

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Keeps the bacteria contained if it does not burst

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Granulomas allow MTb to replicate safely and "freely".

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They can keep the bacteria isolated from the rest of the body preventing spread provided the granuloma stays intact

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Allows the spread of infection

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If the granuloma doesn’t break, it’s a good protective barrier to prevent the infection from being available within the body

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Granulomas provide a concentrated space for replication of the pathogen to occur

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Granulomas recruit monocytes and lymphocytes

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it keeps all of the bacteria isolated and contained, preventing it from spreading elsewhere

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The granuloma keeps the Mtb contained and prevents it from spreading to the rest of the body.

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Prevents the spread of TB if the immune system can safely isolates Mtb.

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Prevents the spread of TB if the immune system can safely isolates Mtb.

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Granulomas can contain MTb and stop the spread of infection.

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It provides a secure place for the infection to replicate and spread due to the nutrient availability inside

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Granulomas provide a somewhat safe space for MTb to replicate inside of until enough has accumulated that it can break down the fibrous cuff and rupture the granule, spreading more efficiently to the rest of the body (strength in numbers)

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Provide space for TB to replicate

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Isolates the bacteria and keeps them for spreading

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Allows for a concentrated infection of the pathogen unless the granuloma breaks open

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Provides an environment and ideal space for reproduction

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Granulomas keep the infection contained.

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Granulomas allow the Mtb to stay in one place and not affect the body, aka no symptoms.

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Isolates and keeps spreading

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Prevents the spread of TB through containment

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It keeps the infection/bacterium contained.

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The host's immune response can keep the granulomas contained which is helpful to prevent spread to the rest of the body compared to if mtb wasn't in granulomas.

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Granulomas are advantageous for the host because they prevent the spread of MTb to the rest of the body if the fibrous cuff is maintained, and they can keep the infection dormant for a long time.

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Can provide a safe space to allow replication and survival

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Can provide a safe space to allow replication and survival

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It can help MTb spread and grow in a single specific place.

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The surrounding recruited immune cells provide hosts for the pathogen to replicate inside of

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They can help greatly confine MTb to a single source, and prevent it from spreading.

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Granulomas can prevent the spread by isolation

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Granulomas can prevent the spread by isolation

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The MTb pathogen is encased in a limited area, (temporarily) preventing it from spreading throughout the body

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Determine which drugs are most effective for treatment so as to not prolong it

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Want to ensure that the person is receiving the types of antibiotics that will actually kill the bacteria, making sure the bacteria aren't resistant to the prescribed treatment.

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see which drugs the patient is resistant to. treat them with the drugs that are effective

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TB is an incredibly difficult disease to live with, so making sure the treatment being used will actually be effective helps ensure essential time isn't being wasted on a treatment that doesn't work

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Detecting the susceptibility can streamline treatment and make recovery faster, cheaper, and less likely to negatively impact antibiotic resistance

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Gives a gauge to the person on what to be concerned about. Aware of the likelihood of infection/progression ?

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Determines which drugs can kill TB

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To ensure that the bacteria is not resistant to the antibiotics so that effective treatment is given

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To see which antibiotics will be effective vs the ones that will have no effect.

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Due to tb being slow growing, the ability for it become immune to ABx is very likely

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Determining effectively and resistance of various antibiotic treatments

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To determine the effectiveness of a drug

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This is done so that the resistance of TB to specific antibiotics can be evaluated. This allows for the narrowing down of which antibiotics would be effective treatment options

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See which drug is most useful to the patient. Don't want antibiotic resistance by using top-of-the-line drugs.

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See which drug is most useful to the patient. Don't want antibiotic resistance by using top-of-the-line drugs.