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Works Cited

“Hemophilia.” Genome.gov, www.genome.gov/genetics-glossary/hemophilia.

Henderson, Wendy. “6 Famous People With Hemophilia.” Hemophilia News Today, 24 Aug. 2017, hemophilianewstoday.com/2017/08/24/six-famous-people-with-hemophilia/.

“How Is Hemophilia Treated?” HOA, www.hoacny.com/patient-resources/blood-disorders/what-hemophilia/how-hemophilia-treated.

St&ouml;ppler, Melissa Conrad. “What Is Hemophilia? Definition, Symptoms of Hemophilia A and B.” MedicineNet, MedicineNet, 6 Dec. 2018, www.medicinenet.com/hemophilia/article.htm#what_causes_hemophilia.

St&ouml;ppler, Melissa Conrad. “What Is Hemophilia? Definition, Symptoms of Hemophilia A and B.” MedicineNet, MedicineNet, 6 Dec. 2018, www.medicinenet.com/hemophilia/article.htm#what_causes_hemophilia.

St&ouml;ppler, Melissa Conrad. “What Is Hemophilia? Definition, Symptoms of Hemophilia A and B.” MedicineNet, MedicineNet, 6 Dec. 2018, www.medicinenet.com/hemophilia/article.htm#what_causes_hemophilia.

St&ouml;ppler, Melissa Conrad. “What Is Hemophilia? Definition, Symptoms of Hemophilia A and B.” MedicineNet, MedicineNet, 6 Dec. 2018, www.medicinenet.com/hemophilia/article.htm#what_causes_hemophilia.

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Challenge: What medical treatment is currently available?

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Challenge: What medical treatment is currently available?

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The main treatment for hemophilia is called replacement therapy. Concentrates of clotting factor VIII or clotting factor IX are slowly dripped or injected into a vein. These infusions help replace the clotting factor that's missing or low.

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What famous (or well known) people have the disorder?

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What famous (or well known) people have the disorder?

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Alexandra Borstein, Comedian, film writer, actress and voice artist, Alex is most recognized for her work as the voice of Family Guy’s Lois Griffin. She’s also appeared in other films such as Casper, Barbie and Power Rangers. Alexandra is a carrier of hemophilia, as well as an active advocate for the disease. Barry Haarde, Cyclist Barry Haarde is a hemophilia advocate who has cycled across America twice to raise awareness of the disease. He was infected with HIV and hepatitis C during a blood transfusion more than 30 years ago and campaigns for access to medication for people in developing countries. He is the only man with HIV, hepatitis C, and hemophilia to have cycled across the country. Jesse Shrader, Jesse Schrader was a professional baseball player who played in an independent league despite living with severe hemophilia A. The left-handed pitcher had to ice his arm after every game and although he no longer plays professionally, he still plays for two different amateur teams. Queen Victoria, Queen Victoria was a carrier of hemophilia B, a disease that she passed on to two of her daughters and one of her sons resulting in high-profile royal cases of hemophilia in Russia, Spain and Germany.  Her son, Prince Leopold, died in 1884 following a fall, and through her daughter’s marriages into other European royal families, other monarchs were born with the disease, including Tsarevich Alexei Nikolaevich, who was born with the disease in 1904 and ended up being wheelchair-bound due to complications. Nikolaevich was killed along with the rest of the Russian royal family during the Russian Revolution in 1918.

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What is the rate of occurrence with the genetic disorder?

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What is the rate of occurrence with the genetic disorder?

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So gender is encoded on a pair of chromosomes, the 23rd pair of chromosomes. For females there are two X chromosomes, and for males there are an X and a Y chromosome. The hemophilia gene, or coding for the specific blood-clotting factor, is actually found on the X chromosome

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What type of mutation causes this genetic disorder?

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What type of mutation causes this genetic disorder?

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It never said in any of the articles, Mrs. Weber approved that.

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Determine the cause of the disorder:  genetic or hereditary.

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Determine the cause of the disorder:  genetic or hereditary.

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Hemophilia is an inherited disease that's characterized by bleeding beyond what would be expected in a normal individual. Hemophilia A is caused by a deficiency of clotting Factor VIII, while hemophilia B (also called Christmas disease) results from a deficiency of Factor IX

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What other organ systems are affected and how?

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What other organ systems are affected and how?

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It can affect joints, muscles, Gl or urinary tract, or brain or skull. Symptoms include excessive bleeding from any site in the body; long-term damage to joints from repeated bleeding episodes is characteristic.

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What phenotypes does the genetic disorder show (appearance)?

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What phenotypes does the genetic disorder show (appearance)?

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Hemophilia A and B are inherited in an X-linked recessive genetic pattern, so males are commonly affected while females are usually carriers of the disease