# data[].attributes.body
1. GENERIC NAME: Aspirin (Acetylsalicyclic acid)
2. BRAND NAME: Easprin, Ecotrin, Aspen, Aspilets/Aspilets-EC, Asthromed, Bayer Aspirin, Cortal 500, Tromcor

3. STOCK DOSAGE

Gum (chewable): 227mg

Tablets (chewable): 81mg

Enteric-coated Tablets: 81mg, 162mg, 325mg, 500mg, 650mg, 975mg

Tablets (film-coated): 325mg, 500mg

Sustained-Release Tablets: 650mg, 800mg

Suppositories: 120mg, 200mg, 300mg, 600mg

4. CLASSIFICATION

Pharmacologic Class: Nonsteroidal anti-inflammatory drug (NSAID)

Therapeutic Class: Nonopioid analgesic, antipyretic, antiplatelet drug

Chemical Class: Salicylate

Pregnancy Risk Category: C (with full dose in third trimester: D)

# data[].attributes.body
The medication inhibits the formation of prostaglandins, which reduces pain and inflammation. The mechanism of fever reduction is unknown, but it could be linked to a decrease in endogenous pyrogens in the hypothalamus as a result of prostaglandin inhibition. By decreasing the formation of prostacyclin and thromboxane A2, the medication causes an antiplatelet effect.

Anti-inflammatory action: Inhibits prostaglandin synthesis. Involved in enhancing antigen removal and in reducing the spread of inflammation

Analgesic action: Principally peripheral with limited action in the CNS, possibly on the hypothalamus; results in relief of mild to moderate pain

Antipyretic  action:  Lowers  body  temperature  in  fever  by  indirectly  causing centrally mediated peripheral vasodilation and sweating

Antiplatelet  action:  High  serum  salicylate  concentrations  can  impair  hepatic synthesis of blood coagulation factors VII, IX, and X, possibly by inhibiting action of vitamin K

# data[].attributes.body
Relieves  pain  of  low  to  moderate  intensity; for  various  inflammatory  conditions  (acute rheumatic fever, systemic lupus, rheumatoid arthritis, osteoarthritis, bursitis, and calcific tendonitis); reduces fever (selected febrile conditions); reduces recurrence of temporary blockage of blood to the brain (Transient Ischemic Attack) and heart attack (Myocardial Infarction); and is used for Kawasaki disease and thromboembolic disorders

# data[].attributes.body
•       Hypersensitivity to salicylates, other NSAIDs, or tartrazine

•       Renal impairment

•       Severe hepatic impairment

•       Hemorrhagic states or blood coagulation defects

•       Vitamin K deficiency caused by dehydration

•       Pregnancy (doses >100mg daily during 3rd trimester)

•       Lactation

•       Hemorrhagic Disease

•       Concomitant use with other NSAIDs and methotrexate

•       Concurrent anticoagulant use

•       Use with extreme caution, if at all, in: hepatic disorders, anemia, asthma, gastritis, Hodgkin’s disease, heart failure or other conditions in which high sodium content is harmful (buffered aspirin), patients receiving other salicylates or NSAIDs concurrently, elderly patients, and in children and adolescents

# data[].attributes.body
Blood  and  lymphatic  system:  Anemia, Hypoprothrombinaemia, Thrombocytopenia

Gastrointestinal: Dyspepsia, Gastric irritation, Nausea, Vomiting

Nervous system: Dizziness, confusion

Respiratory,  thoracic,  and  mediastinal  disorders:  Asthma,  Bronchospasm, Dyspnea, Rhinitis

Skin and subcutaneous tissue disorders: Rash urticaria

Potentially Fatal: Paroxysmal bronchospasm and dyspnea, Coma, Cardiovascular  collapse,  Respiratory  failure,  Severe  hypoglycemia,  Reye’s Syndrome (Rarely),  Hypersensitivity  reactions  (e.g.,  stevens  Johnson  syndrome, angioedema), Gastrointestinal bleeding and perforation

# data[].attributes.body
Instruct patient to take aspirin with food or after meals because it may cause GI upset if taken on an empty stomach

Instruct patient to stop taking aspirin and notify prescriber if any symptoms of stomach or intestinal bleeding occur such as passage of black, bloody, or tarry stools or if patient is coughing up blood or vomit (coffee ground like)

Tell  patient  to  consult  prescriber  before  taking  aspirin  with  any  prescription  drug  for blood disorder, diabetes, gout, or arthritis

Advise the patient to avoid alcohol ingestion as much as possible because GI bleeding may occur

Advise  parents  not  to  give  aspirin  to  a  child  or  adolescent  with  chickenpox  or  flu symptoms because of risk of Reye’s syndrome, and consult for an alternative drug

Advise adult patient not to take ibuprofen while taking a low-dose aspirin (may reduce the cardioprotective and strong preventive effects)

Triple check the label and prescription because overdose may lead to acute poisoning

# data[].attributes.body
1. GENERIC NAME: Atenolol
2. BRAND NAME: Antipressan, Atenix, Novo-Atenol, Tenormin

3. STOCK DOSAGE

Tablets: 25mg, 50mg, 100mg

Vial: 5mg/10mL

4. CLASSIFICATION

Pharmacologic Class: Beta-adrenergic blocker

Therapeutic Class: Antianginal, anti- hypertensive

Pregnancy Risk Category: D

# data[].attributes.body
The drug reduces cardiac output, peripheral resistance, and myocardial oxygen consumption by blocking beta1-adrenergic (myocardial) receptors. It also inhibits renin secretion without altering beta2-adrenergic receptors (pulmonary, vascular, and uterine receptors). The therapeutic effect is it increases systemic blood pressure and coronary blood flow.

# data[].attributes.body
For hypertension, angina pectoris, and acute myocardial infarction

# data[].attributes.body
Cardiogenic shock

Sinus bradycardia

Greater than first-degree heart block

Heart failure (unless secondary to a tachyarrhythmia treatable with beta-adrenergic blockers)

Pulmonary edema

Pregnancy

Hypersensitivity  to  atenolol

Use cautiously in patients with renal failure, hepatic impairment, pulmonary disease, diabetes mellitus, thyrotoxicosis, pregnant or breastfeeding patients, and children

# data[].attributes.body
CNS: fatigue, lethargy, vertigo, drowsiness, dizziness, depression, disorientation, short-term memory loss

CV: hypertension, intermittent claudication, cold arms and legs, orthostatic hypotension, bradycardia, arrhythmias, heart failure, cardiogenic shock, myocardial reinfarction

EENT: blurred vision, dry eyes, eye irritation, conjunctivitis, stuffy nose, rhinitis, pharyngitis, laryngospasm

GI: nausea, vomiting, diarrhea, constipation, gastric pain, flatulence, anorexia, ischemic colitis, retroperitoneal fibrosis, acute pancreatitis, mesenteric arterial thrombosis

GU: impotence, decreased libido, dysuria, nocturia, Peyronie’s disease, renal failure

Hematologic: agranulocytosis

Hepatic: hepatomegaly

Metabolic: hypoglycemia
Musculoskeletal: muscle cramps, back and joint pain

Respiratory: dyspnea, wheezing, respiratory distress, bronchospasm, bronchial obstruction, pulmonary emboli

Other: decreased exercise tolerance, allergic reaction, fever, development of antinuclear antibodies, hypersensitivity reaction

Adverse reactions:  Overdose may  produce profound  bradycardia,  hypotension. Abrupt withdrawal may result in diaphoresis, palpitations, headache, tremors. May precipitate  HF,  MI  in  pts  with cardiac  disease;  peripheral  ischemia  in  pts  with existing  peripheral  vascular  disease.  Hypoglycemia  may  occur  in  previously controlled diabetes. Thrombocytopenia (unusual bruising, bleeding) occurs rarely.

# data[].attributes.body
Watch for signs and symptoms of hypersensitivity reaction

Monitor vital signs(especially blood pressure), ECG, and exercise tolerance

Check closely for hypotension in hemodialysis patients

Check and verify the medication to be administered. The medication label should  be  checked  three  times  and  prepare  the  correct  dosage  of  the medication without contaminating it

Introduce  self  and  verify  the  client’s  identity  by  asking  their  name  and checking  their  ID  band  and  educate  the  client  about  the  therapeutic purpose, possible side effects/adverse effects of the medication

Ask for a history of hypersensitivity to atenolol

If  the  patient  has  angina  pectoris,  record  onset,  quality  (sharp,  dull, squeezing),  radiation,  location,  intensity,  duration  of  anginal  pain, precipitating factors (exertion, emotional stress)

Make position changes slowly and in stages, particularly from lying to standing position to avoid hypotensive effect

Monitor blood glucose level regularly if patient is diabetic; drug may mask signs and symptoms of hypoglycemia

Document the client’s response to medication

PATIENT TEACHING:

Instruct patient to immediately report signs and symptoms of allergic response, breathing problems, and chest pain

Instruct  the  client  to  adhere  rigidly  to  dose  regimen  and  to  not  abruptly  discontinue the medication. Sudden discontinuation of drug can exacerbate angina and precipitate tachycardia or MI in patients with coronary artery disease

Advise patient to take drug at same time every day.

Inform patient that he may experience serious reactions if he stops taking drug suddenly. Advise him to consult prescriber before discontinuing

Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.

Tell the patient that drug may cause a temporary blood pressure decrease if he stands or sits up suddenly. Instruct him to rise slowly and carefully

Instruct the client to restrict alcohol intake because it can increase the blood pressure lowering effect of the medication

Inform women that drug shouldn’t be taken during pregnancy. Urge them to report planned or suspected pregnancy

Tell men that drug may cause erectile dysfunction. Advise them to discuss this issue with the prescriber

As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, and behaviors mentioned above