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Do not function

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Lymphoblasts do not mature

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Philadelphia Chromosome is mostly related to CML

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Treated with Tyrosine Kinase inhibitors to prevent BCR-ABL from causing leukemia

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BCR gene from Chromosome 22 fuses with ABL gene on Chromosome 9

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Damage to DNA of cells in the bone marrow

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Gene abnormality where sections of both Chromosomes 9 and 22 break off and switch spots

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B and T lymphocytes

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Fever
Frequent infections
Night sweats
Unplanned weight loss
Splenomegaly

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Shows >20% lymphoblasts

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Blast cells dominate the CBC

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Commonly involves CNS, kidneys, or testicles

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Infection prone

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Easy bleeding; epistaxis, gum bleeding

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Pallor, fatigue, SOB

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Crowds out formation of PLTs in the bone marrow

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Crowds out formation of PLTs in the bone marrow

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Crowds out formation of healthy WBCs in the bone marrow

# data[].attributes.subject
Crowds out formation of healthy WBCs in the bone marrow

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Crowds out formation of RBCs in the bone marrow

# data[].attributes.subject
Crowds out formation of RBCs in the bone marrow

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Cease maturation and remain in the blast phase