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Side of effects of the diseases and the treatments

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Side of effects of the diseases and the treatments

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Fatigue, sleep apnea, breathing difficulties, scoliosis, kyphosis, Roussy-Lévy Syndrome and hearing loss are all side effects of CMT. Treatment side effects include physical therapy or exercise pain. Patients also have a long list of drugs they cannot use, such as vincristine and taxol, which weaken and could kill them. Patients should also try to avoid alcohol because it can worsen their balance and mobility.

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People with CMT in the family can take a genetic or electrodiagnostic test such as nerve conduction velocity test (NCV). These can help parents and/or the patient prepare for what lies ahead, such as strengthening muscles to delay CMT symptoms.

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Frequent tripping, ankle sprains, clumsiness and pins-and-needles sensations in the feet or hands are usually the first signs of someone with CMT. Typically, doctors first notice the problem during reflex tests, like the knee jerk, whuch CMT patients will have little to no reaction to. Other symptoms include poor tolerance for cold temperatures, weak legs, and foot deformities. These are all caused by the weakened nervous system that characterizes CMT disease.

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There are many different types of CMT and many different genes are linked to the disease: 90, to be specific, and the list is growing. They are all linked to some protein mutation, whether it be deletion, insertion, duplication, or mutation on Chromosome 17.

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Physical therapy and moderate exercise are mainly the treatments used to control CMT since there is no cure. Supports, like a brace, orthopedic device or special sneakers, can help with balance. Pain medication and orthopedic surgery can help alleviate or improve some pain.

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The disease can be inherited through the 17th chromosome, meaning that offspring of parents with the faulty 17th chromosome can inherit the disease.

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Europeans are slightly more likely to have the disease compared to others, although not by much. Norwegians, specifically, are also slightly more likely than the average person to be diagnosed with CMT.