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MeSH: Tobacco Use Disorder

"Transtorno por consumo de tabaco"

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("Tobacco Use Disorder"[MeSH]) AND ("Health Education"[MeSH] OR "Behavior Therapy"[MeSH] OR "Nicotine Replacement Therapy"[MeSH])

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MeSH: Smoking Cessation

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mesh: Counseling

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(("counseling"[MeSH Terms]) AND "Behavior Therapy"[Mesh]) AND "Smoking Cessation Agents"[Mesh]

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Affiliations

¹ Albert Einstein College of Medicine, Bronx, New York.

² University of Kentucky College of Medicine, Lexington, Ketuncky.

³ Inova Schar Heart and Vascular, Falls Church, Virginia.

⁴ University of Maryland School of Medicine, Baltimore, Maryland.

⁵ University of Chicago, Chicago, Illinois.

Randomized Controlled Trial

Affiliations

¹ Albert Einstein College of Medicine, Bronx, New York.

² University of Kentucky College of Medicine, Lexington, Ketuncky.

³ Inova Schar Heart and Vascular, Falls Church, Virginia.

⁴ University of Maryland School of Medicine, Baltimore, Maryland.

⁵ University of Chicago, Chicago, Illinois.

Abstract

People with human immunodeficiency virus (HIV; PWH) smoke cigarettes at triple the rate of the general population in the United States. Efforts to increase quit rates in this group have met with limited success. The nicotine metabolite ratio (NMR) has shown promise as a phenotypic marker that may be useful in selecting the most appropriate cessation treatments for people who smoke cigarettes. We completed a randomized controlled trial of individual intensive counseling and/or varenicline treatment for PWH in the Baltimore area who smoke cigarettes, and we measured serum 3' hydroxycotinine and cotinine at baseline and calculated the ratio of these two values, i.e., the NMR, for each participant. Herein, we present summary statistics and measures of association, or lack thereof, of NMR values with a variety of behavioral parameters and clinical outcomes related to tobacco use and tobacco treatment. The NMR was calculated for 155 PWH who were currently using tobacco cigarettes. The mean age was 52.9 years, 62.3% male, 91.0% Black, and they smoked a mean of 10.6 cigarettes/day. The mean NMR was 0.43, similar to that reported from other PWH cohorts. We did not find any significant correlation between NMR and cigarettes/day, nicotine dependence, temptation to smoke, or nicotine withdrawal symptoms. We did not find that lower NMR was predictive of successful cessation, nor was it associated with varenicline intolerance in those who received varenicline. Prevention Relevance: People with HIV suffer disproportionately from lung, head and neck, and other tobacco-related cancers as a consequence of high smoking rates. There is an urgent need to mitigate this harm, and the use of the NMR to personalize tobacco treatment is an area of active interest.

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smoking cessation agents / therapeutic use

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national center for biotechnology information

# data[].attributes.attachment_link.title
Nicotine Metabolite Ratio in People with HIV Who Smoke Cigarettes Receiving Pharmacologic and Behavioral Cessation Therapy - PubMed

# data[].attributes.attachment_link.description
People with human immunodeficiency virus (HIV; PWH) smoke cigarettes at triple the rate of the general population in the United States. Efforts to increase quit rates in this group have met with limited success. The nicotine metabolite ratio (NMR) has shown promise as a phenotypic marker that may be ...

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https://jamanetwork.com/journals/jama/fullarticle/2775287

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Webb, J., Peerbux, S., Ang, A., Siddiqui, S., Sherwani, Y., Ahmed, M., MacRae, H., Puri, H., Majeed, A., & Glasner, S. (2022). Efectividad a largo plazo de una intervención de terapia cognitivo-conductual digital asistida por un médico para dejar de fumar: resultados secundarios de un ensayo controlado aleatorizado. Investigación sobre la nicotina y el tabaco : revista oficial de la Sociedad para la Investigación de la Nicotina y el Tabaco, 24(11), 1763–1772. https://doi.org/10.1093/ntr/ntac113

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Long-Term Effectiveness of a Clinician-Assisted Digital Cognitive Behavioral Therapy Intervention for Smoking Cessation: Secondary Outcomes From a Randomized Controlled Trial - PubMed

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The long-term effectiveness of clinician-assisted digital smoking cessation interventions has not been well studied. This study established the long-term effectiveness of an extended CBT-based intervention; results may inform implementation of scalable approaches to smoking cessation in the health s …

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Acceptance & Commitment Therapy; QuitGuide; iCanQuit; nicotine dependence; smartphone applications; smoking cessation.

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( Adults[MeSH] ) AND ( Tobacco Use Disorder[MeSH] OR Nicotine Dependence[MeSH] ) AND ( Cognitive Behavioral Therapy[MeSH] ) AND ( Smoking Cessation[MeSH] )

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Declaración de interés.Ninguno de los autores tiene interés económico en la aplicación iCanQuit. Nancy A. Rigotti ha sido consultora de Achieve Life Sciences y recibió financiación de la empresa para realizar un ensayo clínico de un medicamento en investigación para dejar de fumar (citisina). https://pubmed.ncbi.nlm.nih.gov/36683573/

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Acceptance and Commitment Therapy-Based Smartphone Applications for Cessation of Tobacco Use among Adults with High Nicotine Dependence: Results from the iCanQuit Randomized Trial - PubMed

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Background: With 1 in 2 adult tobacco users being highly dependent on nicotine, population-based interventions specifically designed for this group are urgently needed. This study used data from a randomized trial to evaluate whether (1) Acceptance and Commitment Therapy (ACT) delivered via a …

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