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lyssa viruses.

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a)WHO Expert Consultation on Rabies : second report. (2013). World Health Organization.

b) Kienzle. (2007). Rabies. Chelsea House.

c) Fooks, Cliquet, F., Finke, S., Freuling, C., Hemachudha, T., Mani, R. S., Müller, T., Nadin-Davis, S., Picard-Meyer, E., Wilde, H., & Banyard, A. C. (2017). Rabies. Nature Reviews. Disease Primers, 3(1), 17091–17091. https://doi.org/10.1038/nrdp.2017.91

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a) Wash the wound with soap and water.

b) contact your healthcare provider as soon as possible.

c) You may get a vaccine to prevent rabies (post exposure prophylaxis (PEP)

d) if you are high risk for rabies, ask your provider about pre-exposure prophylaxis (PREP)

e) Pet owner should make sure pet's vaccination are up to date.

f)   Do not let your pet 's roam free without supervision.

g) If you have been attacked by an aggressive wild animal, call animal control.

h)    Bats are most common source of rabies in U.S if you find bat where you are sleeping, assume you have been bitten.

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Ongoing hydrophobia, develop prolonged, apnea period, have flaccid paralysis.

Following the onset of stage 4, without supportive care due to cardiopulmonary failure, most patient experience death within two to three days. Even with supportive therapy, zero patients survive rabies.

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Immediate post exposure prophylaxis (PEP) can prevent disease. PEP typically consists of a series of rabies vaccine and in, some case, rabies immune globulin. Once rabies symptom appears, treatment is palliative, focusing on easing the patient suffering. That's why prevention through PEP crucial in cases of potential exposure to the virus.

Human Rabies Immune Globulin (HRIG) these antibodies are given as soon as possible after the bite. HRIG allows your body to begin to detect and fight the rabies virus right away. This helps provide protection until your body starts making its own antibodies after getting the vaccine.

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Test are performed on combination of clinical symptom, history of exposure to potential infected animal and laboratory test. Direct fluorescents antibody test can perform on patient sample of saliva, serum, spinal fluid, skin biopsies of hair follicles at the nape of neck.

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6.Most important virulence factor of pathogen and how specifically the virulence factor contribute to pathogen 

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6.Most important virulence factor of pathogen and how specifically the virulence factor contribute to pathogen 

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The glycoprotein and matrix protein of rabies virus affect pathogenicity by regulating viral replication and facilitating cell-to-cell spread.

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1) Prodromal stage Non-specific symptom, including fever, headache, itching, tingling, pain at site of wound.

2)Furious stage last for few days to week, hyperactivity, agitation, hallucinations, erratic behavior, hydrophobia, hypersensitive to light and sound.

3)Paralytic (dumb) Rabies muscle weakness, paralysis, lack of coordination, coma.

4)coma and death

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1)Direct contact (such as through broken skin or mucous membrane in the eye, nose, or mouth) with saliva or brain/nervous system tissue from infected animal.

2) Bites from infected animal.

3)Scratched from infect animal.

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Negative-sense, non-segmented, single-stranded RNA virus measuring approximately 180 nm long and 75 nm wide. The rabies genome encodes five proteins: nucleoprotein (N), phosphoprotein (P), matrix protein (M), glycoprotein (G) and polymerase (L).

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Negative stranded RNA virus of Rhabdoviridae family.