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This is Algernon, the lab mouse. He has gone through an operation to boost his level of intellect. For a while, he was very intelligent. As time passed, his health and intelligence began to deteriorate.

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Charlie Gordon was a mentally slow adult. He went through the same operation that Algernon had. In similarity, he also had a boost of intellect. This added intelligence helped him discover many things that he was unaware of before, such as "reading the room." Eventually, this intelligence starts to fade.

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Ms. Kinnian was a teacher for the slow adults. Prior to Charlie's surgery, she was his educator. She would help him improve his speech, grammar, and teach him simple life skills. As Charlie became smarter, he realized that he developed actual romantic feelings towards her.

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Dr. Strauss and Dr. Nemur are scientists that perform surgery on Charlie Gordon. This surgery was to increase his intelligence. Dr. Strauss is more kind and considerate, while Dr. Nemur is more focused on the scientific aspects. Both of these scientists played a huge role on Charlie's improvement.

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Joe and Frank were "friends" of Charlie. Originally, they took advantage of Charlie not understanding that they were being mean. As Charlie grew in intelligence, they began to leave him alone and teased him less. Once Charlie lost his intelligence again, they seemed protective and caring for him.