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Haematology at a glance (Fourth Edition) - Atul B. Mehta, A. Victor Hoffbrand

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Haematology at a glance (Fourth Edition) - Atul B. Mehta, A. Victor Hoffbrand

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Very basic

Introduces basic mechanisms of haematological malignancies

Provides a basic overview of Chronic Myeloid Leukaemia

Pathophysiology

Clinical features

Treatment

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(Apperly, Jane F., 2015. Chronic myeloid leukaemia. The Lancet, 285, 1447-1459)

Published in The Lancet, a peer-reviewed medical

Introduces and goes into some detail on:

Pathophysiology of CML

Diagnosis of CML

Goes into great detail on treatment of CML

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(Lavallade, Hughes, 2013. Chronic myeloid leukaemia. Medicine, 41 (5), 275-277)

Published in medicine, a well known peer-reviewed journal

Goes into brief detail on treatment of CML

Gives definitions of the phases (i.e. chronic, accelerated, blastic)

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(Poonam, J., et al, 2012. FISH patterns of BCR/ABL1 fusion in chronic myelogenous leukaemia at diagnosis. Indian journal of pathology and microbiology, 55 (3), 347-351)

Talks about the diagnosis of CML using fluorescence in situ hybridisation (FISH)

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Formation of the Philadelphia chromosome

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Formation of the Philadelphia chromosome

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https://www.cancer.gov/types/leukemia/patient/cml-treatment-pdq

Clearly shows how translocation of chromosomes 9 and 22 produce the Philadelphia chromosome