# data[].attributes.body
HSCs develop from hemangioblasts within the mesoderm. Each HSC undergoes mitosis to produce 2 daughter cells: a copy of itself (self-renewal), to ensure there is enough HSC or take over the role of the other cell if it is damaged, and a blood cell, which is then differentiated into either of the 2 groups: myeloid progenitor or lymphoid progenitor to make further differentiation into other types of blood cells.
https://www.youtube.com/watch?v=UY9vfLkYuz8#t=555.967606
https://www.youtube.com/watch?v=pzse2g4xBFU

# data[].attributes.body
When cut into 5 pieces, it can be seen to regenerate back because of mitosis.

Mitosis involves replication of the genetical material in cells. Nucleus is divided

# data[].attributes.body
They are plant tissue which are found on root tips and shoots. They are made up of unspecialised cells that can reproduce by mitosis.

# data[].attributes.body
https://www.youtube.com/watch?v=qq5k1sWqLO0

# data[].attributes.body
go through mitosis

# data[].attributes.body
The new shoots fom the burnt tree develop as a result of mitosis.

# data[].attributes.body
The new shoots from the trunk develop

# data[].attributes.body
- its regenerative capacity means planarians can clone themselves. (If a starfish loses some of its 'arms', new ones are regenerated by mitosis.

# data[].attributes.body
The cell cycle is an important role for the reproduction of fungi. Fungus or mould, which you see on food such as bread, grows by the process of mitosis. When a single fungal spore lands on food, it grows into a mass of threads which can be called hyphae(each branching filament that make up the mycelium in fungus).
Specialised stalks grow up and form the mass of hyphae, each having a spore case at the it tip. Mitosis of fungi occurs in the spore case, where thousands of black spores are formed. When the spore case matures, it splits open and  tiny spores are scattered. When conditions are favourable, each spore germinates and grows a new hyphal mass.

# data[].attributes.body
The growth of epicormic shoots involves the making of new cells.the cells ae made theough the procces of mitosis .
Cells then reproduce to give rise to new cells this is due to buds below the bark that contain tissue called meristem.

The buds beneath the bark will not grow unless all the leaves have been destroyed.

# data[].attributes.headline
epicormic shoots are the new green leafy shoots produced underneath the bark of a eucalyptus tree.

# data[].attributes.subject
epicormic shoots are the new green leafy shoots produced underneath the bark of a eucalyptus tree.

# data[].attributes.body
In human skin, the surface cells are replaced by the daughter basal stem cells. Each basal stem cell undergoes mitosis to produce 2 new cells but only one will become a keratinocyte in the skin surface. The other one remains in the basal layer. Within 48 days, the whole epidermis is replaced by new cells. For a new cell to move from where it is formed to the surface takes about 2 weeks. In order for it to be shed takes another 4 weeks. This cell cycle activity of the basal stem cells are very important to replace the dead skin cells of a person which on average, loses about 30-40 thousand an hour.

# data[].attributes.attachment_link.readable_text
Altmetric: 9

Citations: 45

More detail

Review Article

Guiomar Solanas 1 n4

Guiomar Solanas carried out her doctoral work at the Universitat Autònoma de Barcelona (UAB), Spain, with Mireia Duñach. She then conducted her postdoctoral studies at the Institute for Research in Biomedicine (IRB), Barcelona, Spain, on intestinal biology and homeostasis under the supervision of Eduard Batlle. In January 2012, she joined the laboratory of Salvador Aznar Benitah at the Center for Genomic Regulation (CRG), Barcelona, Spain, and since September 2013 she has been a research associate in his laboratory at the IRB.

& Salvador Aznar Benitah 1, 2, 3 n4

Salvador Aznar Benitah obtained his bachelor honours degree in biochemistry at McGill University, Montreall, Canada, and his Ph.D in molecular oncology at the Universidad Autónoma de Madrid, Spain. He did his postdoctoral research at the London Research Institute (Cancer Research UK) under the supervision of Fiona Watt. In 2007, he established his independent laboratory at the Center for Genomic Regulation (CRG) Barcelona, Spain, as an ICREA (Institució Catalana de Recerca i Estudis Avançats) Junior Researcher. Since September 2013, he has been an ICREA Research Professor at the Institute for Research in Biomedicine (IRB), Barcelona, Spain. The main goal of his laboratory is to understand how adult stem cells are spatio-temporally regulated in health, cancer and ageing. Salvador Aznar Benitah's homepage

Nature Reviews Molecular Cell Biology 14, 737-748 (2013)

doi:10.1038/nrm3675

Download Citation

Published:

# data[].attributes.attachment_link.title
Regenerating the skin: a task for the heterogeneous stem cell pool and surrounding niche

# data[].attributes.attachment_link.description
It is becoming clear that the stem cells from the mammalian epidermis are more heterogeneous than previously anticipated, comprising populations with specific properties and lineage preferences. There is also evidence of crosstalk between epidermal stem cells and surrounding cell populations to ensure their survival and homeostasis.

# data[].attributes.body
In a normal cell cycle the number of new cells produced balances the number of lost cells.

- When the rate of new cells produced exceeds the rate of cells lost, a build of cells results.

The difference between cancer cells and normal cell cycle:

-Normal cells grow, divide and then die, however cancer cells only divide and form into a tumor.

Normal cell compared to cancer cell.

https://www.youtube.com/watch?v=8LhQllh46yI
(How cancer cells spread)

# data[].attributes.body
The epithelial lining of the small intestine grow new cells every 4 to 5 days to replace dead cells.
They are produced by intestinal stem cells, which are found at the base of infoldings called crypts, in between the villi. The stem cells go through mitosis to produce 2 new cells, with one replacing the original stem cell, and the other move to the villi.
The new cells move from the crypts to the villi and replace dead cells which from 2 to 7 days.
The small intestine is divided in two regions, the differentiated region and proliferative region

# data[].attributes.body
The parent breaks into two or more pieces and each piece grows into a new planarian. New parts are produced by mitosis of cells and each new planarian is an exact copy of the parent,

# data[].attributes.body
Haematopoietic stem cells (HSCs) are found in the bone marrow, they can renew themselves, undergo apoptosis, mobilize in and out of the bone marrow into the circulating blood to divide and differentiate into various types of blood cells(red blood cells, white blood cells, platelets) through the process of haematopoiesis.

# data[].attributes.body
- Are flatworms that live in water and reproduce asexually by regeneration

# data[].attributes.body
-Cancers may result from a breakdown of the normal control of the cell cycle.

- In cancerous cells the checkpoints are overridden therefore the cell will continue to divide even though the DNA is damage. This results with errors in their DNA and passing on the error onto their daughter cells causing a malignant tumour.

-While in normal cells, checkpoints exist to ensure that the DNA passing on to the daughter cells is complete and damage-free. If a error is detected , the cell cycle is stopped until the error is fixed.

http://www.cancer.ca/~/media/CCE/5850/ecc7d1d27275a4b9cb29cf31ea08780d.png (Cancer Development)

http://cancerprevent.org/images/about-cancer-illustration.gif (Stages of Cancer Cells)