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Leonardo da Vinci’s Mona Lisa is a small portrait of Lisa Gherardini, famed for her elusive smile, painted in the early 1500s and now housed in the Louvre.

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Painted by Michelangelo around 1511–1512, The Creation of Adam is one of the most celebrated frescoes on the ceiling of the Sistine Chapel in Vatican City

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Painted by Raphael between 1509 and 1511, The School of Athens is a monumental fresco in the Stanza della Segnatura of the Vatican’s Apostolic Palace

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The Birth of Venus was painted by Sandro Botticelli around 1484–1486 during the Italian Renaissance.